Challenge and opportunity: The two edges of continuous-flow photochemistry

Article Multidisciplinary Sciences

Intermolecular [2π+2σ]-photocycloaddition enabled by triplet energy transfer

Roman Kleinmans et al.

Summary: In this study, a new intermolecular [2+2]-photocycloaddition method using bicyclo[1.1.0]butanes as 2 sigma-electron reactants was reported. This reaction was realized by visible-light-mediated triplet energy transfer catalysis. The method allows for a simple, modular, and diastereoselective synthesis of bicyclo[2.1.1]hexanes and extends to a-bonds, providing previously inaccessible structural motifs.

NATURE (2022)

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Article Multidisciplinary Sciences

Membrane-based TBADT recovery as a strategy to increase the sustainability of continuous-flow photocatalytic HAT transformations

Zhenghui Wen et al.

Summary: This study presents organic solvent nanofiltration (OSN) as a solution to reduce TBADT consumption and increase its turnover number, enabling large-scale photocatalytic transformations. With in-line TBADT recovery, the observed product yields are comparable to those of reactions performed with pristine TBADT.

NATURE COMMUNICATIONS (2022)

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Article Chemistry, Physical

A photoredox-catalyzed approach for formal hydride abstraction to enable Csp3-H functionalization with nucleophilic partners (F, C, O, N, and Br/Cl)

Yufei Zhang et al.

Summary: A catalytic C-sp(3)-H functionalization method is reported, which combines hydrogen-atom transfer and radical-polar crossover in a single catalytic cycle using visible-light photoredox catalysis. This method enables functionalization of C-H bonds with nucleophilic fluoride, halides, alcohols, and other nucleophiles.

CHEM CATALYSIS (2022)

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Article Multidisciplinary Sciences