A diet supplemented with cholic acid elevates blood pressure accompanied by albuminuria in rats

A diet supplemented with cholic acid (CA), the primary 12 alpha-hydroxylated bile acid, can induce hepatic lipid accumulation in rats without obesity. This study examined the effects of a CA-supplemented diet on blood pressure (BP). After acclimation, WKAH/HkmSlc rats (3 weeks old) were divided into two groups and fed with a control AIN-93-based diet or a CA-supplemented diet (0.5 g CA/kg) for 13 weeks. The CA diet increased systolic and diastolic BP as well as hepatic lipid concentrations in the rats. No changes were found in the blood sodium concentration. Urinary albumin concentration increased in CA-fed rats. An increase was observed in the hepatic expression of ATP-binding cassette subfamily B member 1B that correlated BPs and urinary albumin concentration accompanied by an increase in portal taurocholic acid concentration. These results suggest that 12 alpha-hydroxylated bile acids are involved in increased BP and albuminuria via alteration of hepatic function.

Automated summary

The study found that a diet supplemented with CA (cholic acid) can lead to hepatic lipid accumulation and affect blood pressure in rats without obesity.