4.4 Review

The past, present, and future of artificial zinc finger proteins: design strategies and chemical and biological applications

期刊

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
卷 28, 期 3, 页码 249-261

出版社

SPRINGER
DOI: 10.1007/s00775-023-01991-6

关键词

Zinc finger; Redesign; Metalloprotein; Zinc protein; Artificial protein; Gene editing

向作者/读者索取更多资源

Zinc finger proteins, which play important roles in various biological functions, have been extensively studied. Artificial zinc finger proteins have been designed and created to improve their functions and expand their applications, including gene editing. This review summarizes previous studies on the redesign and application of artificial zinc finger proteins, and discusses different design strategies and potential biological applications.
Zinc finger proteins are abundant in the human proteome and are responsible for a variety of functions. The domains that constitute zinc finger proteins are compact spherical structures, each comprising approximately 30 amino acid residues, but they also have precise molecular factor functions: zinc binding and DNA recognition. Due to the biological importance of zinc finger proteins and their unique structural and functional properties, many artificial zinc finger proteins have been created and are expected to improve their functions and biological applications. In this study, we review previous studies on the redesign and application of artificial zinc finger proteins, focusing on the experimental results obtained by our research group. In addition, we systematically review various design strategies used to construct artificial zinc finger proteins and discuss in detail their potential biological applications, including gene editing. This review will provide relevant information to researchers involved or interested in the field of artificial zinc finger proteins as a potential new treatment for various diseases.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.4
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据