Synthesis and In Vitro Antibacterial Screening of Some Novel4-Amino-N-(4-Phenylthiazol-2-yl)Benzene Sulfonamide Derivatives

We synthesized some newer thiazole analogs and screened them for antibacterial action against some selected bacterial strains by using cup plate method. In the present work, we synthesized 4-amino-N-(4-phenylthi-azol-2-yl)benzene sulfonamide derivatives (2a-f) by refluxing substituted 4-phenyl thiazol-2-amine derivatives with 4-aminobenzene-1-sulfonyl chloride in presence of pyridine and acetic anhydride. The structures of title compounds were confirmed by Infrared, Proton nuclear magnetic resonance, Mass spectral, and elemental analysis. The antibacterial and antifungal activities of title compounds (2a-f) reported that compounds, 2d, 2e, and 2f are showing good activity against Staphylococcus aureus at 300 mu g/mL, and compound 2b has good activity against Bacillus subtilis. Whereas compounds 2c, 2e, and 2f have shown good activity against Escherichia coli. Compound 2d was showing good activity against Klebsiella pneumoniae at 300 mu g/mL.

Automated summary

We synthesized new thiazole analogs and tested their antibacterial activity against selected bacterial strains using the cup plate method. By refluxing substituted 4-phenyl thiazol-2-amine derivatives with 4-aminobenzene-1-sulfonyl chloride in the presence of pyridine and acetic anhydride, we synthesized 4-amino-N-(4-phenylthi-azol-2-yl)benzene sulfonamide derivatives (2a-f). The structures of these compounds were confirmed through various analysis methods. The results showed that compounds 2d, 2e, and 2f exhibited good activity against Staphylococcus aureus, compound 2b showed good activity against Bacillus subtilis, and compounds 2c, 2e, and 2f showed good activity against Escherichia coli, while compound 2d showed good activity against Klebsiella pneumoniae.