期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 88, 期 3, 页码 1578-1589出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.2c02640J
关键词
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An efficient and straightforward strategy for the synthesis of isoquinolones through [4 + 2]-annulation was described. Through utilizing N-chlorobenzamides and vinyl acetate, isoquinolone derivatives were prepared in good yields with the presence of CoCp*(III) catalyst in a regioselective manner. Furthermore, the annulation reaction was diversified by using vinyl ketones. Mechanistic investigations such as deuterium labeling study and competition experiment were performed to support the proposed reaction mechanism.
An efficient and straightforward strategy for the synthesis of isoquinolones through [4 + 2]-annulation of N-chlorobenzamides with vinyl acetate in the presence of CoCp*(III) catalyst in a regioselective manner is described. Furthermore, the annulation reaction was diversified by using vinyl ketones. By utilizing this strategy, biologically valuable isoquinolone derivatives were prepared in good yields. Subsequently, isoquinolone derivatives were further transformed into 1-chloroisoquinolines in the presence of POCl3. Furthermore, mechanistic investigations such as deuterium labeling study and competition experiment were performed to O O CI POCl3 N R, iota * cost effective Co catalyst * Isoquinolones * Internal oxidizing DG * ambient temperature * functional group tolerance Me support the proposed reaction mechanism.
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