☆ 4.3 Article

Continuous-flow photochemistry as an automated platform integrated with closed-loop AI/ML approaches

CHEM CATALYSIS (2023)

Automated Nanomole-Scale Reaction Screening toward Benzoate Bioisosteres: A Photocatalyzed Approach to Highly Elaborated Bicyclo[1.1.1]Pentanes

James J. Mousseau et al.

Summary: Through the application of high-throughput nanoscale optimization, a mild, photocatalyzed Minisci-like protocol was developed to access highly functionalized 1,3-disubstituted bicyclopentanes. The strategy utilized a readily available organic photocatalyst to prepare benzoate-isosteric compounds, avoiding the need for precious metals. The described approach provided products in synthetically useful yields and was demonstrated to be executable in parallel medicinal chemistry format.

ACS CATALYSIS (2022)

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Review Chemistry, Multidisciplinary

Ready, Set, Flow! Automated Continuous Synthesis and Optimization

Christopher P. Breen et al.

Summary: Synthetic chemistry has opened up new possibilities for innovation in key industries such as medicine, energy, and agriculture. Automation is challenging the traditional process of chemical synthesis, while continuous flow chemistry presents a flexible platform for automation. The merger of synthesis and automation is expected to democratize access to custom complex small molecules and accelerate the development of new synthetic protocols.

TRENDS IN CHEMISTRY (2021)

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Review Physics, Multidisciplinary