☆ 4.5 Review

Precision periodontal care: from omics discoveries to chairside diagnostics

CLINICAL ORAL INVESTIGATIONS (2023)

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Article Dentistry, Oral Surgery & Medicine

Cytokine profiles and the dynamic of gingivitis development in humans

Fabio R. M. Leite et al.

Summary: The study found that fast gingivitis development was associated with higher levels of non-organized response and lower levels of organized response, while slow responders were not associated with gingivitis. The results suggest that individual variability may play a role in susceptibility to gingivitis.

JOURNAL OF CLINICAL PERIODONTOLOGY (2022)

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Article Chemistry, Analytical

ImmunoDisk-A Fully Automated Bead-Based Immunoassay Cartridge with All Reagents Pre-Stored

Benita Johannsen et al.

Summary: In this paper, the authors present a fully automated sample-to-answer centrifugal microfluidic cartridge that integrates a wash-free bead-based immunoassay. The system allows for simple fluidic structure and quick detection of C-reactive protein. The authors also investigate the air drying process for protein-coupled beads and propose a drying protocol. The results show that the system has good reproducibility and stability. The authors encourage further testing and implementation of this system in clinical studies and diagnostic applications.

BIOSENSORS-BASEL (2022)

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Article Dentistry, Oral Surgery & Medicine

Implementing of aMMP-8 point-of-care test with a modified new disease classification in Finnish adolescent cohorts

Anna M. Heikkinen et al.

Summary: This study aimed to investigate the usefulness of aMMP-8 chairside-test results in alerting initial or early periodontitis in adolescents. The results showed that positive aMMP-8 POCT results can be regarded as an early alarm for emerging risks.

CLINICAL AND EXPERIMENTAL DENTAL RESEARCH (2022)

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Review Dentistry, Oral Surgery & Medicine

aMMP-8 Oral Fluid PoC Test in Relation to Oral and Systemic Diseases

Timo Sorsa et al.

Summary: The manuscript highlights the benefits of active-matrix metalloproteinase-8 (aMMP-8) chairside/point-of-care diagnostic tools in oral and systemic diseases. Previous studies support aMMP-8 as a more precise biomarker compared to other markers. The lateral flow aMMP-8 point-of-care testing shows comparable results to protease activity assays and can be applied in various medical fields.

FRONTIERS IN ORAL HEALTH (2022)

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Review Dentistry, Oral Surgery & Medicine

Metatranscriptomic analyses of the oral microbiome

Ana E. Duran-Pinedo

Summary: The oral microbiome composition and gene-expression profiles play crucial roles in disease development, especially in periodontal disease and caries. The functional activities of different species within the subgingival microbiota are interconnected, and efforts are being made to identify changes associated with transitions between health and disease.

PERIODONTOLOGY 2000 (2021)

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Review Dentistry, Oral Surgery & Medicine

Did Omics change periodontal therapy?

Magda Feres et al.

Summary: Studies using next-generation sequencing techniques to evaluate the periodontal microbiome have revealed insights into classic periodontal pathogens, as well as the discovery of new species/genera. Additionally, species and genera associated with periodontal health were found to increase in levels in healthy individuals and post-therapy. While OMICS knowledge has not yet influenced daily clinical practice, it opens up new possibilities for future research in personalized periodontal treatments.

PERIODONTOLOGY 2000 (2021)

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Review Dentistry, Oral Surgery & Medicine

Metaproteome and metabolome of oral microbial communities

Nagihan Bostanci et al.

Summary: This article focuses on metaproteomic and metabolomic approaches for oral biologic samples, revealing the functionality and underlying regulatory processes within various oral microbial communities. Knowledge of the proteomic interplay and metabolic interactions of microorganisms within oral biofilm and salivary microbiome communities is presented and discussed from clinical and basic research perspectives.

PERIODONTOLOGY 2000 (2021)

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Review Dentistry, Oral Surgery & Medicine

Probing periodontal microbial dark matter using metataxonomics and metagenomics

Purnima S. Kumar et al.

Summary: The study of the periodontal microbial community has been influenced by a long history of cultivation-based and microscopic investigations, leading to the recognition of a discrepancy between culturable and uncultured bacteria. The development of DNA sequencing as a tool to study microbial dark matter has revolutionized the field, enabling the discovery of new species and functions and challenging traditional views on the role of the oral microbiome in health and disease.

PERIODONTOLOGY 2000 (2021)

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Review Dentistry, Oral Surgery & Medicine

Optimizing the quality of clinical studies on oral microbiome: A practical guide for planning, performing, and reporting

Egija Zaura et al.

Summary: This review aims to improve the quality standards of clinical studies with microbiome as an output parameter. It discusses the existing evidence for good quality practices in oral microbiome studies, including study design, sample collection, data processing, and interpretation.

PERIODONTOLOGY 2000 (2021)

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Review Dentistry, Oral Surgery & Medicine

Microbial signatures of health, gingivitis, and periodontitis

Loreto Abusleme et al.

Summary: The subgingival crevice contains diverse microbial communities that undergo shifts with the development of gingivitis and periodontitis, showing specific associations between gingival tissue status and subgingival microbiome. Despite methodological differences, distinct community structures were found for health, gingivitis, and periodontitis, suggesting a continuum between gingivitis and periodontitis.

PERIODONTOLOGY 2000 (2021)

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Article Chemistry, Analytical

One-step, wash-free, bead-based immunoassay employing bound-free phase detection

Benita Johannsen et al.

Summary: This study introduces a simple and fast one-step heterogeneous immunoassay method that can be adapted to miniaturized, automated point-of-care systems. It utilizes magnetic and fluorescent beads for capture and detection, successfully applied in the detection of CRP and oral inflammation markers, showcasing multiplexing capacity.

ANALYTICA CHIMICA ACTA (2021)

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Article Chemistry, Analytical

OralDisk: A Chair-Side Compatible Molecular Platform Using Whole Saliva for Monitoring Oral Health at the Dental Practice

Desiree Baumgartner et al.

Summary: Periodontitis and dental caries are major non-communicable diseases that impact oral health and overall well-being. The use of the disk-shaped microfluidic platform known as OralDisk allows for efficient detection of bacteria associated with these diseases, showing high potential for implementation in dental care settings.

BIOSENSORS-BASEL (2021)

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Article Multidisciplinary Sciences

Validation and verification of predictive salivary biomarkers for oral health

Nagihan Bostanci et al.

Summary: The study found that combining multiple biomarker assays provides higher predictive accuracy for gingivitis and periodontitis compared to using single biomarkers, with over 90% accuracy for distinguishing between gingivitis and healthy groups, and 100% accuracy for distinguishing between periodontitis and healthy or gingivitis groups. Additionally, the ratios of biomarkers MMP-8, MMP-9, and TIMP-1 were found to be powerful differentiating values compared to single biomarkers.

SCIENTIFIC REPORTS (2021)

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Article Health Care Sciences & Services

Salivary Biomarkers for Dental Caries Detection and Personalized Monitoring

Pune N. Paque et al.

Summary: This study identified four salivary biomarkers crucial for predicting caries accurately and developed an RF model for classification and prediction of caries progression. The high correlation between RF prediction and clinical classification was observed, indicating a new approach for caries identification.

JOURNAL OF PERSONALIZED MEDICINE (2021)

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Review Biochemical Research Methods

Active matrix metalloproteinase-8 (aMMP-8) point-of-care test (POCT) in the COVID-19 pandemic

Timo Sorsa et al.

Summary: aMMP-8 is a potential biomarker for periodontal and peri-implant diseases, with POCT assays such as mouthrinse aMMP-8 being noninvasive and real-time for detection, treatment, and prevention. The clinical interdisciplinary utilization of aMMP-8 POCT requires further studies in oral, medical, and interdisciplinary fields.

EXPERT REVIEW OF PROTEOMICS (2021)

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Review Dentistry, Oral Surgery & Medicine

Genomics of periodontal disease and tooth morbidity

Thiago Morelli et al.

PERIODONTOLOGY 2000 (2020)

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Review Dentistry, Oral Surgery & Medicine

Advances in precision oral health

James D. Beck et al.

PERIODONTOLOGY 2000 (2020)

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Article Biochemical Research Methods

Label-Free Quantitative Proteomics versus Antibody-Based Assays to Measure Neutrophil-Derived Enzymes in Saliva

Angelika Silbereisen et al.

PROTEOMICS CLINICAL APPLICATIONS (2020)

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Article Biochemical Research Methods

Salivary Fingerprinting of Periodontal Disease by Infrared-ATR Spectroscopy

Kerstin Meta-Catherina Beyer-Hans et al.

PROTEOMICS CLINICAL APPLICATIONS (2020)

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Editorial Material Biochemical Research Methods

Revisiting -omics in Oral Health and Disease

Nagihan Bostanci

PROTEOMICS CLINICAL APPLICATIONS (2020)

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Article Dentistry, Oral Surgery & Medicine

Salivary proteotypes of gingivitis tolerance and resilience

Nagihan Bostanci et al.

JOURNAL OF CLINICAL PERIODONTOLOGY (2020)

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Article Medicine, General & Internal

Microbial Analysis of Saliva to Identify Oral Diseases Using a Point-of-Care Compatible qPCR Assay

Pune N. Paque et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Article Infectious Diseases

Healthcare Challenges and Future Solutions in Dental Practice: Assessing Oral Antibiotic Resistances by Contemporary Point-Of-Care Approaches

Georgios N. Belibasakis et al.

ANTIBIOTICS-BASEL (2020)

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Article Genetics & Heredity

Salivary Total Protease Activity Based on a Broad-Spectrum Fluorescence Resonance Energy Transfer Approach to Monitor Induction and Resolution of Gingival Inflammation

Floris J. Bikker et al.

MOLECULAR DIAGNOSIS & THERAPY (2019)

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Article Chemistry, Analytical

Automated Pre-Analytic Processing of Whole Saliva Using Magnet-Beating for Point-of-Care Protein Biomarker Analysis

Benita Johannsen et al.

MICROMACHINES (2019)

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Article Biochemistry & Molecular Biology

Salivary levels of MPO, MMP-8 and TIMP-1 are associated with gingival inflammation response patterns during experimental gingivitis

Gustavo G. Nascimento et al.

CYTOKINE (2019)

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Article Dentistry, Oral Surgery & Medicine

Identification of inflammatory response patterns in experimental gingivitis studies

Gustavo G. Nascimento et al.

EUROPEAN JOURNAL OF ORAL SCIENCES (2019)

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Article Dentistry, Oral Surgery & Medicine

Regulation of PGLYRP1 and TREM-1 during Progression and Resolution of Gingival Inflammation

A. Silbereisen et al.

JDR CLINICAL & TRANSLATIONAL RESEARCH (2019)

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Review Dentistry, Oral Surgery & Medicine

Gingival crevicular fluid and its immune mediators in the proteomic era

Nagihan Bostanci et al.

PERIODONTOLOGY 2000 (2018)

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Article Biochemical Research Methods

Targeted Proteomics Guided by Label-free Quantitative Proteome Analysis in Saliva Reveal Transition Signatures from Health to Periodontal Disease

Nagihan Bostanci et al.

MOLECULAR & CELLULAR PROTEOMICS (2018)

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Review Medicine, Research & Experimental

Saliva diagnostics - Current views and directions

Karolina Elzbieta Kaczor-Urbanowicz et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2017)

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Review Biochemical Research Methods

Contribution of proteomics to our understanding of periodontal inflammation

Nagihan Bostanci et al.

PROTEOMICS (2017)

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Article Cell Biology

Protein Quality Assessment on Saliva Samples for Biobanking Purposes

Nuno Rosa et al.

BIOPRESERVATION AND BIOBANKING (2016)

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Article Dentistry, Oral Surgery & Medicine

Comparison of red autofluorescing plaque and disclosed plaque-a cross-sectional study

Catherine M. C. Volgenant et al.

Clinical Oral Investigations (2016)

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Article Dentistry, Oral Surgery & Medicine

Dynamics of red fluorescent dental plaque during experimental gingivitis-A cohort study

Monique H. van der Veen et al.

JOURNAL OF DENTISTRY (2016)

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Article Cell Biology

Protein Quality Assessment on Saliva Samples for Biobanking Purposes

Nuno Rosa et al.

BIOPRESERVATION AND BIOBANKING (2016)

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Review Microbiology

Survival proteomes: the emerging proteotype of antimicrobial resistance

Amber J. Park et al.

FEMS MICROBIOLOGY REVIEWS (2016)

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Article Cell Biology

Reproducible quantitative proteotype data matrices for systems biology

Hannes L. Roest et al.

MOLECULAR BIOLOGY OF THE CELL (2015)

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Article Multidisciplinary Sciences

Differentiation of oral bacteria in in vitro cultures and human saliva by secondary electrospray ionization - mass spectrometry

Lukas Bregy et al.

SCIENTIFIC REPORTS (2015)

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Review Immunology

On putative periodontal pathogens: an epidemiological perspective

Rodrigo Lopez et al.

VIRULENCE (2015)

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Review Infectious Diseases

Bacterial proteases: targets for diagnostics and therapy

W. E. Kaman et al.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2014)

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Article Dentistry, Oral Surgery & Medicine

Expanding the Foundation for Personalized Medicine: Implications and Challenges for Dentistry

I. Garcia et al.

JOURNAL OF DENTAL RESEARCH (2013)

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Article Microbiology

Highly Specific Protease-Based Approach for Detection of Porphyromonas gingivalis in Diagnosis of Periodontitis

Wendy E. Kaman et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2012)

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Article Dentistry, Oral Surgery & Medicine

Personalized Medicine: Will Dentistry Ride the Wave or Watch from the Beach?

K. S. Kornman et al.

JOURNAL OF DENTAL RESEARCH (2012)

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Review Dentistry, Oral Surgery & Medicine

What do 'omic technologies have to offer periodontal clinical practice in the future?

M. M. Grant

JOURNAL OF PERIODONTAL RESEARCH (2012)

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Review Dentistry, Oral Surgery & Medicine

Comparative Human Salivary and Plasma Proteomes

J. A. Loo et al.

JOURNAL OF DENTAL RESEARCH (2010)

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Editorial Material Medicine, General & Internal

The Path to Personalized Medicine

Margaret A. Hamburg et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

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Article Biochemical Research Methods

Inter-individual variability of protein patterns in saliva of healthy adults

Mercedes Quintana et al.

JOURNAL OF PROTEOMICS (2009)

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Article Dentistry, Oral Surgery & Medicine

Relationship between IL-1A polymorphisms and gingival overgrowth in renal transplant recipients receiving Cyclosporin A

Nagihan Bostanci et al.

JOURNAL OF CLINICAL PERIODONTOLOGY (2006)

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Article Dentistry, Oral Surgery & Medicine

Prognostic factors in the treatment of generalized aggressive periodontitis: II. Effects of smoking on initial outcome

Francis J. Hughes et al.

JOURNAL OF CLINICAL PERIODONTOLOGY (2006)

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Article Dentistry, Oral Surgery & Medicine

Prognostic factors in the treatment of generalized aggressive periodontitis: I. Clinical features and initial outcome

Francis J. Hughes et al.

JOURNAL OF CLINICAL PERIODONTOLOGY (2006)

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