4.5 Article

Nicorandil protects podocytes via modulation of antioxidative capacity in acute puromycin aminonucleoside-induced nephrosis in rats

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Mechanisms and significance of tissue-specific MICU regulation of the mitochondrial calcium uniporter complex

Chen-Wei Tsai et al.

Summary: Mitochondrial Ca2+ uptake is regulated by the mitochondrial Ca2+ uniporter and plays important roles in various physiological functions. Skeletal-muscle and kidney uniporters also interact with a MICU1-MICU1 homodimer, while cardiac uniporters mostly lack MICUs. Cells use protein-import machinery to regulate the abundance of MICU1 homo- and heterodimers and protect properly assembled dimers from proteolysis. However, enhancing Ca2+ uptake can lead to increased ATP production, but also elevated ROS levels, impaired basal metabolism, and higher susceptibility to death.

MOLECULAR CELL (2022)

Article Urology & Nephrology

Safety and Efficacy of GFB-887, a TRPC5 Channel Inhibitor, in Patients With Focal Segmental Glomerulosclerosis, Treatment-Resistant Minimal Change Disease, or Diabetic Nephropathy TRACTION-2 Trial Design

Liron Walsh et al.

Summary: TRACTION-2 is a phase 2a study investigating the efficacy and safety of GFB-887, a podocyte-targeting TRPC5 inhibitor, in patients with FSGS, TR-MCD, or DN. The study aims to evaluate the impact of increasing doses of GFB-887 on proteinuria, as well as assess safety, tolerability, pharmacokinetic/pharmacodynamic profiles, and the potential correlation of urinary Rac1 with treatment efficacy.

KIDNEY INTERNATIONAL REPORTS (2021)

Article Medicine, Research & Experimental

Complex consequences of Cantu syndrome SUR2 variant R1154Q in genetically modified miceS

Haixia Zhang et al.

Summary: Cantu syndrome is caused by gain-of-function mutations in potassium channel subunits. An experiment with CRISPR/Cas9 found that R1154Q mutation led to lower K-ATP current density in cardiomyocytes and vascular smooth muscle. Surprisingly, there were distinct SUR2 transcripts, one encoding full-length protein and one with an in-frame deletion, present in R1154Q tissues.

JCI INSIGHT (2021)

Article Integrative & Complementary Medicine

Huayu Tongluo Recipe Attenuates Renal Oxidative Stress and Inflammation through the Activation of AMPK/Nrf2 Signaling Pathway in Streptozotocin- (STZ-) Induced Diabetic Rats

Yachun Li et al.

Summary: The study found that HTR can reduce oxidative stress and inflammation in the kidneys of diabetic rats through activating the AMPK/Nrf2 signaling pathway and inhibiting the Nox4/TGF-beta 1 signaling, thus reducing accumulation of extracellular matrix and protecting the kidney from the effects of DN.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2021)

Article Pathology

Databases for technical aspects of immunohistochemistry: 2021 update

Takayasu Moroki et al.

Summary: This technical report presents the results of a survey conducted among members of the Conference on Experimental Animal Histopathology from 2018 to 2019, focusing on the technical aspects of immunohistochemistry (IHC) and supplier details of 509 primary antibodies. Additionally, it provides information on the immunological properties and IHC staining conditions for these antibodies.

JOURNAL OF TOXICOLOGIC PATHOLOGY (2021)

Review Physiology

Sex differences in renal mitochondrial function: a hormone-gous opportunity for research

Regina F. Sultanova et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2020)

Review Physiology

The complicated role of mitochondria in the podocyte

Nehaben A. Gujarati et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2020)

Review Biochemistry & Molecular Biology

Oxidative Stress in the Pathogenesis and Evolution of Chronic Kidney Disease: Untangling Ariadne's Thread

Anila Duni et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Pharmacology & Pharmacy

Charting a TRP to Novel Therapeutic Destinations for Kidney Diseases

Juan Lorenzo Pablo et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2019)

Article Physiology

Progression of diabetic kidney disease in T2DN rats

Oleg Palygin et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2019)

Review Cardiac & Cardiovascular Systems

Calcium Signaling and Reactive Oxygen Species in Mitochondria

Edoardo Bertero et al.

CIRCULATION RESEARCH (2018)

Article Biochemistry & Molecular Biology

Mechanisms underlying modulation of podocyte TRPC6 channels by suPAR: Role of NADPH oxidases and Src family tyrosine kinases

Eun Young Kim et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2018)

Article Medicine, Research & Experimental

The mitochondrial calcium uniporter underlies metabolic fuel preference in skeletal muscle

Jennifer Q. Kwong et al.

JCI INSIGHT (2018)

Article Cell Biology

Podocyte Injury and Albuminuria in Experimental Hyperuricemic Model Rats

Shinichiro Asakawa et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2017)

Article Pathology

Databases for technical aspects of immunohistochemistry

Satoshi Furukawa et al.

JOURNAL OF TOXICOLOGIC PATHOLOGY (2017)

Article Pharmacology & Pharmacy

An NBD Derivative of the Selective Rat Toxicant Norbormide as a New Probe for Living Cell Imaging

Claudio D'Amore et al.

FRONTIERS IN PHARMACOLOGY (2016)

Article Urology & Nephrology

Long-term Outcome of Biopsy-Proven Minimal Change Nephropathy in Chinese Adults

Cheuk-Chun Szeto et al.

AMERICAN JOURNAL OF KIDNEY DISEASES (2015)

Article Physiology

Quercetin attenuates cyclooxygenase-2 expression in response to acute ureteral obstruction

Inge Carlsen et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2015)

Review Pharmacology & Pharmacy

The mitochondria as a target for cardioprotection in acute myocardial ischemia

Offir Ertracht et al.

PHARMACOLOGY & THERAPEUTICS (2014)

Article Physiology

Combination of ACE inhibitor with nicorandil provides further protection in chronic kidney disease

Takeshi Shiraishi et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2014)

Article Urology & Nephrology

Epithelial Cell TGF beta Signaling Induces Acute Tubular Injury and Interstitial Inflammation

Madeleine E. Gentle et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2013)

Article Pharmacology & Pharmacy

Nicorandil Protects against lschaemia-Reperfusion Injury in Newborn Rat Kidney

Yu-Jing Zhang et al.

PHARMACOLOGY (2013)

Review Physiology

The podocyte's response to stress: the enigma of foot process effacement

Wilhelm Kriz et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2013)

Article Physiology

Nicorandil, a Katp channel opener, alleviates chronic renal injury by targeting podocytes and macrophages

Yoshifuru Tamura et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2012)

Article Physiology

Nicorandil as a novel therapy for advanced diabetic nephropathy in the eNOS-deficient mouse

Katsuyuki Tanabe et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2012)

Article Urology & Nephrology

Podocyte Biology for the Bedside

J. Ashley Jefferson et al.

AMERICAN JOURNAL OF KIDNEY DISEASES (2011)

Article Pharmacology & Pharmacy

Nicorandil ameliorates ischaemia-reperfusion injury in the rat kidney

Shogo Shimizu et al.

BRITISH JOURNAL OF PHARMACOLOGY (2011)

Article Physiology

Mineralocorticoid receptor activation: a major contributor to salt-induced renal injury and hypertension in young rats

Hiroo Kawarazaki et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2011)

Article Cell Biology

ARF in the mitochondria The last frontier?

Koji Itahana et al.

CELL CYCLE (2008)

Review Medicine, General & Internal

Nephrotic syndrome in adults

Richard P. Hull et al.

BMJ-BRITISH MEDICAL JOURNAL (2008)

Review Medicine, General & Internal

Interventions for minimal change disease in adults with nephrotic syndrome

S. C. Palmer et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2008)

Review Medicine, General & Internal

Immunosuppressive treatment for focal segmental glomerulosclerosis in adults

Norbert Braun et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2008)

Article Cell Biology

Localization of sulfonylurea receptor subunits, SUR2A and SUR2B, in rat heart

Ming Zhou et al.

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (2007)

Article Pharmacology & Pharmacy

Nicorandil attenuates the mitochondrial Ca2+ overload with accompanying depolarization of the mitochondrial membrane in the heart

H Ishida et al.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2004)

Article Multidisciplinary Sciences

The mitochondrial calcium uniporter is a highly selective ion channel

Y Kirichok et al.

NATURE (2004)

Article Surgery

Ischemic preconditioning improves mitochondrial tolerance to experimental calcium overload

JA Crestanello et al.

JOURNAL OF SURGICAL RESEARCH (2002)

Article Cardiac & Cardiovascular Systems

Opening of mitochondrial KATP channels attenuates the ouabain-induced calcium overload in mitochondria

H Ishida et al.

CIRCULATION RESEARCH (2001)

Article Neurosciences

Mitochondria and calcium: from cell signalling to cell death

MR Duchen

JOURNAL OF PHYSIOLOGY-LONDON (2000)

Article Pharmacology & Pharmacy

Lack of a role for inducible nitric oxide synthase in an experimental model of nephrotic syndrome

LM Walker et al.

BIOCHEMICAL PHARMACOLOGY (2000)

Article Cardiac & Cardiovascular Systems

Nicorandil, a potent cardioprotective agent, acts by opening mitochondrial ATP-dependent potassium channels

T Sato et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2000)