Identification of aminobenzoic acids as selective inhibitors of the N-terminal phosphatase of soluble epoxide hydrolase

Soluble epoxide hydrolase (EC 3.3.2.10) is a key enzyme in the regulation of inflammation and metabolism, whereas, the role of its N-terminal phosphatase activity (N-phos) has been poorly understood because of a lack of selective inhibitors. Here we report 4-aminobenzoic (K-i 15.3 mu m) and 3-amino-4-hydroxy benzoic acid (K-i 11.7 mu m) as selective competitive inhibitors of N-phos.

Automated summary

Soluble epoxide hydrolase is an important enzyme involved in inflammation and metabolism regulation. The N-terminal phosphatase activity of the enzyme has been poorly understood due to the lack of selective inhibitors. This study identifies 4-aminobenzoic and 3-amino-4-hydroxy benzoic acid as selective competitive inhibitors for N-phos.