Amidation by reactive extrusion for the synthesis of active pharmaceutical ingredients teriflunomide and moclobemide

The solventless synthesis of an amide was performed in a twin-screw extruder in the presence of a coupling agent, providing a high yielding and productive method. The reaction conditions were optimized to prepare APIs, teriflunomide and moclobemide.

Automated summary

The solventless synthesis of an amide was successfully achieved using a twin-screw extruder with the aid of a coupling agent. This method proved to be highly productive and yielded satisfactory results for the preparation of APIs, specifically teriflunomide and moclobemide.