COVID-19 mRNA Vaccine Effectiveness against Elderly Frail People

The frail, elderly population is often characterized by poor immunogenicity post COVID-19 mRNA vaccination. Inflame-ageing and immune-senescence are pathogenetic mechanisms that might explain this phenomenon. Complex interplay with cytokines and microbiota is also implicated in this inflammatory cascade. The abovementioned population, although very important from immunologic perspective, has barely been included in the mRNA vaccination clinical trials.

Automated summary

Frail, elderly individuals have poor immune response after COVID-19 mRNA vaccination, possibly due to inflame-ageing and immune-senescence mechanisms. The complex interaction between cytokines and microbiota also plays a role in this inflammatory cascade. Despite their immunological significance, this population has been rarely included in clinical trials of mRNA vaccination.