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pH-Responsive wound dressings: advances and prospects

NANOSCALE HORIZONS (2023)

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Summary: In the past decade, nanomedicine has seen unprecedented development in disease diagnosis and treatment. Several nanomedicines have been approved for clinical use, demonstrating the potential value of transitioning nanotechnology-modified medicines from the lab to the bedside. The application of artificial intelligence (AI) in the development of nanotechnology-based products has the potential to transform healthcare by enabling the acquisition and analysis of large datasets and tailoring precision nanomedicines for cancer management.

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Summary: A hydrogel composed of GelMA and HA-CHO loaded with GS and LZM drugs is successfully synthesized, showing excellent antibacterial and hemostatic properties. The dual drug-loaded hydrogels exhibit superior antibacterial efficiency, especially inhibiting S. aureus, due to the synergistic effect of LZM and GS.

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A bionic cellulose nanofiber-based nanocage wound dressing for NIR-triggered multiple synergistic therapy of tumors and infected wounds

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Poly e-caprolactone/nanostarch composite nanofibrous wound dressing with antibacterial property and pH stimulus drug release

C. R. Reshmi et al.

Summary: A novel nanostarch-loaded composite nanofibrous membrane of PCL has been developed for wound dressing, showing enhanced hydrophilicity, antibacterial potency, and potential as a pH-responsive transdermal drug delivery material.

CELLULOSE (2022)

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pH responsive release of curcumin from photocrosslinked pectin/gelatin hydrogel wound dressings

Nazli Seray Bostanci et al.

Summary: This study developed hydrogel wound dressings with antimicrobial properties, controlling the release of curcumin by altering the formulation and medium pH. The P1:G3 hydrogels demonstrated high stability and antibacterial efficacy, showing potential as wound dressing materials for treating infected and chronic wounds.

BIOMATERIALS ADVANCES (2022)

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pH-responsive silica nanoparticles for the treatment of skin wound infections

Fei Pan et al.

Summary: pH-sensitive silica nanoparticles were developed for targeted drug release on alkaline chronic wounds. The loaded chlorhexidine exhibited high antibacterial efficacy and no cytotoxicity in alkaline conditions. The study demonstrated the potential of pH-triggered drug release for the treatment of chronic wound infections.

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Summary: The multifunctional hydrogel wound dressing promotes wound healing by providing antibacterial, hemostatic, and adhesive properties, while also enabling real-time monitoring of wound status. The personalized wound management model accurately analyzes and evaluates wound healing and infection status using the colorimetric signal of the hydrogel dressing, achieving high accuracy.

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Nora M. Elkenawy et al.

Summary: Burn wounds are prone to infections and can cause death. This study prepared a hydrogel with silver sulfadiazine embedded in alginate macromolecule, and used it to treat burn wounds infected with S. aureus and E. coli. The results showed that this hydrogel, dyed with prodigiosin, is more effective compared to silver nitrate cream.

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Development of green and sustainable smart biochromic and therapeutic bandage using red cabbage (Brassica oleracea L. Var. capitata) extract into

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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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The potential use of colorimetric pH sensor from Clitoria ternatea flower for indicating bacterial infection in wound dressing application

Kitipong Kiti et al.

Summary: This study utilized a visual pH sensor from Clitoria ternatea flower to evaluate the status of wound infection. The CT extract exhibited potential as a colorimetric pH sensor for wound dressing applications.

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Article Chemistry, Analytical

Stable, reusable, and rapid response smart pH-responsive cotton fabric based on covalently immobilized with naphthalimide-rhodamine probe

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Summary: A stable, reusable, and rapid response pH-responsive smart cotton textile was successfully prepared by immobilizing a naphthalimide-rhodamine (NR) probe onto cotton, offering outstanding sensing performance and potential applications in smart textile sensors across various fields.

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Summary: Polymeric materials have played a crucial role in the development of hydrogels for sustained drug delivery and chronic wound healing. This study focused on the functionalization of bacterial cellulose with graphene oxide to create composite hydrogels with physical-mechanical properties, inherent antimicrobial effects, and controlled drug release. These hydrogels showed potential anticancer activities and were deemed ideal for skin wound healing.

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Chronic wound-dressing chitosan-polyphenolic patch for pH responsive local antibacterial activity

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Summary: Natural or synthetic polymeric films have gained interest in biomedical research due to their biocompatibility. A nanocomposite film using the chitosan-tannic acid (CT) crosslinking process has been developed, showing antibacterial activity and pH-responsive drug release both in vitro and in vivo.

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Bacterial Growth-Induced Tobramycin Smart Release Self-Healing Hydrogel for Pseudomonas aeruginosa-Infected Burn Wound Healing

Ying Huang et al.

Summary: Researchers have developed a self-healing hydrogel with good electrical conductivity and antioxidant activity for burn wound repair. The hydrogel can release antibiotics on demand and shows excellent antibacterial properties, in vivo antibacterial activity, and wound inflammation control compared to conventional dressings. This smart release hydrogel is highly advantageous for bacterial-infected burn wound healing.

ACS NANO (2022)

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Pharmacokinetic control on the release of antimicrobial drugs from pH-responsive electrospun wound dressings

Laura Miranda-Calderon et al.

Summary: The pH of healthy skin changes during wound healing, and chronic non-healing wounds commonly show an alkaline shift. In order to adjust drug release to the specific pH of wounds, drug-loaded wound dressings with pH-responsiveness were developed. These dressings contain antiseptics and antibiotics and exert different release kinetics depending on the pH conditions of each wound type.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

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pH-responsive magnolol nanocapsule-embedded magnolol-grafted-chitosan hydrochloride hydrogels for promoting wound healing

Meng Wang et al.

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Article Biophysics

Self-healing/pH-responsive/inherently antibacterial polysaccharide-based hydrogel for a photothermal strengthened wound dressing

Chenglong Xue et al.

Summary: This study developed a polysaccharide-based hydrogel that can achieve improved antibacterial effects and self-healing properties through photothermal therapy. The hydrogel is also pH-sensitive, allowing for controlled drug release to promote wound healing.

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Article Chemistry, Analytical

pH-Responsive PVA-Based Nanofibers Containing GO Modified with Ag Nanoparticles: Physico-Chemical Characterization, Wound Dressing, and Drug Delivery

Erfan Rahmani et al.

Summary: In this study, PVA/GO-Ag-CUR nanofibers were fabricated using electrospinning method, which exhibited excellent antibacterial properties and promoted wound healing. The nanofibers also showed pH-sensitive release of CUR.

MICROMACHINES (2022)

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Article Chemistry, Multidisciplinary

Curcumin Sustained Release with a Hybrid Chitosan-Silk Fibroin Nanofiber Containing Silver Nanoparticles as a Novel Highly Efficient Antibacterial Wound Dressing

Parisa Heydari Foroushani et al.

Summary: This study successfully fabricated silk fibroin-chitosan-silver-curcumin nanofibers, which have the advantages of pH-responsive release of curcumin, accelerated wound healing, and improved mechanical properties. The concentration of chitosan plays a crucial role in the performance of nanofibers, and the incorporation of silver nanoparticles can enhance drug loading and entrapment efficiency. Nanofibers with lower chitosan concentration exhibit stronger inhibitory effects on bacterial growth, and they do not show any toxic effect on cell culture.

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Yonghui He et al.

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A Copper Peroxide Fenton Nanoagent-Hydrogel as an In Situ pH-Responsive Wound Dressing for Effectively Trapping and Eliminating Bacteria

Yan Zu et al.

Summary: Bacterial infection is a significant threat to wound healing due to antibiotic abuse and drug resistance. In this study, a novel wound dressing called CP@Tf-hy was developed, which has the ability to release copper peroxide nanoparticles and stimulate the release of copper ions, thereby effectively eliminating antibiotic-resistant bacteria and promoting wound healing.

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Article Polymer Science

Smart Methylcellulose Hydrogels for pH-Triggered Delivery of Silver Nanoparticles

Lorenzo Bonetti et al.

Summary: This study introduces a novel MC-based hydrogel for the pH-triggered release of AgNPs in infected wounds. Physicochemical and rheological properties of MC hydrogels were optimized, defining the optimal conditions for crosslinking. MC/AgNPs nanocomposite hydrogels were obtained via an in situ synthesis process using MC as both a capping and reducing agent.

GELS (2022)

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Jingjing Hu et al.

Summary: A smart hydrogel was developed to treat biofilm-associated infections by releasing pectinase and aminoglycoside antibiotics upon bacterial infection, effectively degrading polysaccharides and sensitizing bacteria to antibiotics, ultimately eradicating biofilms and killing embedded bacteria.

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Injectable, Intrinsically Antibacterial Conductive Hydrogels with Self-Healing and pH Stimulus Responsiveness for Epidermal Sensors and Wound Healing

Ling Fan et al.

Summary: This study developed a chitosan-based hydrogel with self-healing, conductive, and antibacterial properties, which can be used as a sensor to monitor human health in real-time and promote wound healing. The injectable hydrogel, fabricated via Schiff base linkage and hydrogen bond, shows pH responsiveness and broad-spectrum antibacterial properties.

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Tzu-Wen Huang et al.

Summary: This study successfully developed smart, stimuli responsive self-assembled multilayer and complex film by reducing the hydrophilicity of HPMC and enhancing mechanical strength, free radical scavenging capability, and water vapor and light barrier properties. The complex film can control EGCG release by tuning pH or temperature and trigger EGCG release in an on-demand fashion under near-infrared exposure.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Polymer Science

Greener therapeutic pH-sensing wound dressing based on Curcuma Longa and cellulose hydrogel

Asmaa Ahmed Arafa et al.

Summary: The study used pH-sensitive hydrogel made from turmeric extract as a cost-effective wound dressing to accelerate wound healing in a neutral medium. It was found that the hydrogel had different release properties and color changes at different pH levels, showing potential for wound healing applications.

EUROPEAN POLYMER JOURNAL (2021)

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Article Biochemistry & Molecular Biology

Smart and pH-sensitive rGO/Arabinoxylan/chitosan composite for wound dressing: In-vitro drug delivery, antibacterial activity, and biological activities

Muhammad Umar Aslam Khan et al.

Summary: The research explored the potential of composite hydrogels based on ARX, CS, and rGO for wound dressing in skin wound healing, demonstrating their excellent antibacterial properties and controlled drug release capabilities. The hydrogels showed pH sensitivity and maximum drug release at pH 7.4 and 37 degrees C, making them promising biomaterials for treating and caring for skin wounds.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Review Biotechnology & Applied Microbiology

Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis

Hamed Nosrati et al.

Summary: The skin serves as the body's primary barrier against external pathogens and maintaining homeostasis. Damage to the skin can have significant impacts on health and quality of life. Tissue engineering aims to enhance tissue regeneration, with improving angiogenesis being one of the most effective treatments for skin tissue regeneration.

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Review Chemistry, Multidisciplinary

Strategy for Treatment of Infected Diabetic Foot Ulcers

Mayland Chang et al.

Summary: Diabetic foot ulcers (DFUs) are chronic wounds that affect 30% of diabetic patients, with dysregulation of the normal wound healing process. Infection in DFUs increases inflammation and delays wound healing. Selective inhibition of MMP-9 may be a promising strategy for treatment of DFUs.

ACCOUNTS OF CHEMICAL RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Development of Antibacterial, Degradable and pH-Responsive Chitosan/Guar Gum/Polyvinyl Alcohol Blended Hydrogels for Wound Dressing

Muhammad Umar Aslam Khan et al.

Summary: The research focused on the fabrication of CS/PVA/GG blended hydrogels with TEOS for sustained paracetamol release. The hydrogels were characterized using various techniques to understand their physicochemical properties and drug release behavior, showing potential for controlled drug delivery and antimicrobial activity.

MOLECULES (2021)

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Article Chemistry, Analytical

Microneedle array with a pH-responsive polymer coating and its application in smart drug delivery for wound healing

Asad Ullah et al.

Summary: In order to successfully treat wounds, therapeutics must be delivered directly to the wound. However, barriers such as necrotic tissue and biofilms make it challenging to efficiently deliver antibiotics to wounds. By utilizing porous polymer coatings on microneedles for automatic release of therapeutics in response to wound pH conditions, researchers were able to significantly enhance therapeutic results for wound infections.

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Article Chemistry, Multidisciplinary

Dual-Dynamic-Bond Cross-Linked Antibacterial Adhesive Hydrogel Sealants with On-Demand Removability for Post-Wound-Closure and Infected Wound Healing

Yuqing Liang et al.

Summary: The research developed a smart bioadhesive hydrogel sealant with self-healing and excellent antibacterial activity, showing high effectiveness in wound closure and post-wound-closure care. The hydrogel features autonomous healing, on-demand dissolution, injectability, good biocompatibility, antibacterial properties, multifunctional adhesiveness, and NIR responsiveness. In vivo evaluation demonstrated the great potential of the smart hydrogel in dealing with skin incisions and infected full-thickness skin wounds.

ACS NANO (2021)

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Article Polymer Science

Antibacterial and Hemocompatible pH-Responsive Hydrogel for Skin Wound Healing Application: In Vitro Drug Release

Muhammad Umar Aslam Khan et al.

Summary: Treatment of skin wounds requires meticulous medical procedures. Blended composite hydrogels made from natural polymers like arabinoxylan play a crucial role in controlled drug release for skin wound care. Maximum swelling of the hydrogels occurs at pH 7, while drug release kinetics follows the Baker-Lonsdale model with high regression coefficient values.

POLYMERS (2021)

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Article Engineering, Environmental

Dual-crosslinked mussel-inspired smart hydrogels with enhanced antibacterial and angiogenic properties for chronic infected diabetic wound treatment via pH-responsive quick cargo release

Cheng Hu et al.

Summary: The study successfully overcame the challenges in healing chronic diabetic wounds, such as bacterial infections and difficulty in angiogenesis, by using a pH-responsive double-crosslinking hydrogel.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Materials Science, Multidisciplinary

pH-responsive hydrogel loaded with insulin as a bioactive dressing for enhancing diabetic wound healing

Zuhao Li et al.

Summary: A self-healing, injectable, and pH responsive hydrogel was successfully synthesized and incorporated with insulin glargine, showing promising potential in accelerating the healing of diabetic foot ulcers by shortening the inflammatory phase, promoting tissue formation, and improving treatment outcomes.

MATERIALS & DESIGN (2021)

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Antibacterial activity of positively charged carbon quantum dots without detectable resistance for wound healing with mixed bacteria infection

Xiaoli Hao et al.

Summary: The study developed positively charged CQDs as a broad-spectrum antibacterial agent, demonstrating effective antibacterial activity against various bacteria and inducing conformational changes in bacterial genes through the generation of reactive oxygen species.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Anti-cN1A Antibodies Are Associated with More Severe Dysphagia in Sporadic Inclusion Body Myositis

Matteo Lucchini et al.

Summary: The study confirmed the low sensitivity and high specificity of anti-cN1A antibodies in s-IBM patients, with a high positive predictive value. The presence of anti-CN1A antibodies was identified as a marker for patients at greater risk of more severe swallowing problems.

CELLS (2021)

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Review Infectious Diseases

Research Progress on Antibacterial Activities and Mechanisms of Natural Alkaloids: A Review

Yumei Yan et al.

Summary: Alkaloids are nitrogen-containing heterocyclic compounds isolated mainly from plants. They exhibit diverse antibacterial activities by inhibiting bacterial cell wall synthesis, changing cell membrane permeability, inhibiting bacterial metabolism, and blocking nucleic acid and protein synthesis. These natural products represent a potential new source for developing antibiotics to combat drug-resistant bacterial infections.

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Copper Peroxide-Loaded Gelatin Sponges for Wound Dressings with Antimicrobial and Accelerating Healing Properties

Haiyan Cui et al.

Summary: This study reports a pH-responsive copper peroxide-loaded wound dressing that can release hydroxyl radicals specifically in bacterial-infected skin wounds, exhibiting good antibacterial properties and promoting wound healing. The strategy presented in this study aims to enhance antibacterial efficacy and reduce toxic side effects by activating the release of hydroxyl radicals through bacterial self-activation.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Fluorescent Magnesium Hydroxide Nanosheet Bandages with Tailored Properties for Biocompatible Antimicrobial Wound Dressings and pH Monitoring

Adam Truskewycz et al.

Summary: Fluorescent magnesium hydroxide nanosheets were synthesized and demonstrated to possess antimicrobial potential for medical applications. These nanosheets can be integrated into antimicrobial bandages and gels, showing good biocompatibility.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Review Chemistry, Multidisciplinary

Functional Hydrogels as Wound Dressing to Enhance Wound Healing

Yongping Liang et al.

Summary: Hydrogels have shown promising advantages as wound dressings due to their excellent biochemical and mechanical properties. This review summarizes the advanced functions of hydrogel dressings, such as antimicrobial, adhesion, hemostasis, anti-inflammatory, substance delivery, self-healing, stimulus response, and conductivity, as well as the emerging wound monitoring feature. The potential applications for different types of wounds, including chronic wounds and focus on infected, burn, and diabetic wounds, are discussed, along with proposed future directions for hydrogel wound dressings in wound healing.

ACS NANO (2021)

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Article Biochemistry & Molecular Biology

Preparation and characterization of smart therapeutic pH-sensitive wound dressing from red cabbage extract and chitosan hydrogel

Asmaa Ahmed Arafa et al.

Summary: The study developed a multifunctional wound dressing using red cabbage extract as a natural pH sensitive indicator and chitosan-based hydrogel, achieving smart therapeutic and comfortable properties. By adjusting the crosslinking method and structure, the hydrogel showed superior mechanical and swelling properties, with color changes indicating the status of the wound.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Chemistry, Multidisciplinary

Advanced Wound Dressing for Real-Time pH Monitoring

Federica Mariani et al.

Summary: The rapid development of wearable technologies is driving the design of textile chemical sensors for real-time collection of vital parameters for improved healthcare. In this study, a smart bandage was developed to monitor wound pH in real time, with a reversible response and high sensitivity in the pH range suitable for wound monitoring. The device, validated in flow analysis using synthetic wound exudate, integrates a pH sensor and an absorbent layer for continuous exudate flow across the sensor area.

ACS SENSORS (2021)

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Article Materials Science, Biomaterials

Injectable, self-healing and pH responsive stem cell factor loaded collagen hydrogel as a dynamic bioadhesive dressing for diabetic wound repair

Li Zhang et al.

Summary: The Col/APG hydrogel loaded with stem cell factor is effective in treating diabetic ulcers, enhancing adhesive strength and promoting cellular response, collagen deposition, and neovascularization in a diabetic rat model. The presence of M2 macrophages in the hydrogel groups suggests potential anti-inflammatory effects and tissue regeneration benefits.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Review Materials Science, Biomaterials

Anti-inflammation biomaterial platforms for chronic wound healing

Zejun Xu et al.

Summary: With the increasing number of chronic wounds, the inflammatory stage has been identified as the rate-limiting stage of healing. Anti-inflammatory strategies have shown effectiveness in increasing the healing rate, and biomaterial platforms based on these strategies are emerging as potential therapies for accelerating chronic wound repair.

BIOMATERIALS SCIENCE (2021)

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Review Pharmacology & Pharmacy

Microneedle for transdermal drug delivery: current trends and fabrication

Jae Hwan Jung et al.

Summary: Transdermal drug delivery has the advantage of bypassing the first-pass effect and allowing sustained release of the drug. Microneedles are a painless, less invasive, and easy to self-administer transdermal drug delivery system with high drug bioavailability. With advancements in formulation technologies, the drug-loading capability of microneedles can be improved.

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Article Chemistry, Multidisciplinary

Nanogel Encapsulated Hydrogels As Advanced Wound Dressings for the Controlled Delivery of Antibiotics

Yanmiao Fan et al.

Summary: Biocompatible and degradable dual-delivery gel systems based on HBDLDs were constructed via thiol-ene click chemistry, allowing tunable elasticity of the gels and co-delivery of NB and CIP. The innovative hybrid hydrogels showed promise in treating bacterial infections and as wound dressing materials with enhanced cell proliferation and biodegradability.

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Construction of porous sponge-like PVA-CMC-PEG hydrogels with pH-sensitivity via phase separation for wound dressing

Yang Li et al.

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Immediate Treatment of Burn Wounds with High Concentrations of Topical Antibiotics in an Alginate Hydrogel Using a Platform Wound Device

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Recent progress of antibacterial natural products: Future antibiotics candidates

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Thermosensitive and pH-responsive tannin-containing hydroxypropyl chitin hydrogel with long-lasting antibacterial activity for wound healing

Mengsi Ma et al.

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Nano-Based Drug Delivery or Targeting to Eradicate Bacteria for Infection Mitigation: A Review of Recent Advances

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Advances in Antimicrobial Microneedle Patches for Combating Infections

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Article Biochemistry & Molecular Biology

Enhanced antimicrobial activity and pH-responsive sustained release of chitosan/poly (vinyl alcohol)/graphene oxide nanofibrous membrane loading with allicin

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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Materials Science, Biomaterials

Novel Self-Healing Hydrogel with Injectable, pH-Responsive, Strain-Sensitive, Promoting Wound-Healing, and Hemostatic Properties Based on Collagen and Chitosan

Cuicui Ding et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

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Review Pharmacology & Pharmacy

Skin Wound Healing Process and New Emerging Technologies for Skin Wound Care and Regeneration

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PHARMACEUTICS (2020)

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Review Biochemistry & Molecular Biology

Advanced Hydrogels as Wound Dressings

Shima Tavakoli et al.

BIOMOLECULES (2020)

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Review Chemistry, Physical

Applications of tannic acid in membrane technologies: A review

Wentao Yan et al.

ADVANCES IN COLLOID AND INTERFACE SCIENCE (2020)

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Review Chemistry, Physical

Tannic Acid with Antiviral and Antibacterial Activity as A Promising Component of Biomaterials-A Minireview

Beata Kaczmarek

MATERIALS (2020)

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Review Pharmacology & Pharmacy

Current trends in polymer microneedle for transdermal drug delivery

Khater Ahmed Saeed AL-Japairai et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

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Review Endocrinology & Metabolism

Lower extremity amputations and long-term outcomes in diabetic foot ulcers: A systematic review

Ayeshmanthe Rathnayake et al.

WORLD JOURNAL OF DIABETES (2020)

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Article Chemistry, Physical

Two-Pronged Strategy of Biomechanically Active and Biochemically Multifunctional Hydrogel Wound Dressing To Accelerate Wound Closure and Wound Healing

Meng Li et al.

CHEMISTRY OF MATERIALS (2020)

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Article Biochemistry & Molecular Biology

Layered biocompatible pH-responsive antibacterial composite film based on HNT/PLGA/chitosan for controlled release of minocycline as burn wound dressing

Alireza Mohebali et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Biochemistry & Molecular Biology

Synthesis of chemically cross-linked hydrogel films based on basil seed (Ocimum basilicum L.) mucilage for wound dressing drug delivery applications

Masoomeh Sadat Hosseini et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Review Materials Science, Biomaterials

New forms of electrospun nanofiber materials for biomedical applications

Shixuan Chen et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Article Materials Science, Biomaterials

Smart wound dressing for infection monitoring and NIR-triggered antibacterial treatment

Bianbian Qiao et al.

BIOMATERIALS SCIENCE (2020)

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Article Chemistry, Applied

Smart wound dressing based on κ-carrageenan/locust bean gum/cranberry extract for monitoring bacterial infections

Karine Modolon Zepon et al.

CARBOHYDRATE POLYMERS (2019)

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Article Biochemistry & Molecular Biology

pH-Thermosensitive hydrogel based on polyvinyl alcohol/sodium alginate/N-isopropyl acrylamide composite for treating re-infected wounds

A. S. Montaser et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Article Nanoscience & Nanotechnology

Sustainable Dual Release of Antibiotic and Growth Factor from pH-Responsive Uniform Alginate Composite Microparticles to Enhance Wound Healing

Ming Shi et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Chemistry, Applied

Mechanically robust and flexible silk protein/polysaccharide composite sponges for wound dressing

Yanfei Feng et al.

CARBOHYDRATE POLYMERS (2019)

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Article Polymer Science

Construction of a sandwich-type wound dressing with pain-reliever and pH-responsive antibiotic delivery system

Ayse Buse Ozdabak-Sert et al.

JOURNAL OF APPLIED POLYMER SCIENCE (2019)

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Article Chemistry, Multidisciplinary

Efficient Angiogenesis-Based Diabetic Wound Healing/Skin Reconstruction through Bioactive Antibacterial Adhesive Ultraviolet Shielding Nanodressing with Exosome Release

Min Wang et al.

ACS NANO (2019)

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Review Biochemistry & Molecular Biology

Architecture of antimicrobial skin defense

Kamila Kwiecien et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2019)

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Review Polymer Science

Advancements in nanofibers for wound dressing: A review

Rushikesh S. Ambekar et al.

EUROPEAN POLYMER JOURNAL (2019)

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Article Chemistry, Applied

Rapid self-healing, stretchable, moldable, antioxidant and antibacterial tannic acid-cellulose nanofibril composite hydrogels

Wenjiao Ge et al.

CARBOHYDRATE POLYMERS (2019)

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Review Pharmacology & Pharmacy

Advanced drug delivery systems and artificial skin grafts for skin wound healing

Hye Sung Kim et al.

ADVANCED DRUG DELIVERY REVIEWS (2019)

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Review Nutrition & Dietetics

Curcumin and Cancer

Antonio Giordano et al.

NUTRIENTS (2019)

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Article Engineering, Biomedical

Near-infrared light-controllable on-demand antibiotics release using thermo-sensitive hydrogel-based drug reservoir for combating bacterial infection

Ge Gao et al.

BIOMATERIALS (2019)

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Article Polymer Science

pH-responsive cellulose-based dual drug-loaded hydrogel for wound dressing

Xiaocheng Fan et al.

EUROPEAN POLYMER JOURNAL (2019)

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Article Materials Science, Biomaterials

Color-changing smart fibrous materials for naked eye real-time monitoring of wound pH

Nan Pan et al.

JOURNAL OF MATERIALS CHEMISTRY B (2019)

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Review Pharmacology & Pharmacy

Challenges and opportunities of pH in chronic wounds

Laura A. Wallace et al.

THERAPEUTIC DELIVERY (2019)

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Article Biochemistry & Molecular Biology

Bioinspired pH- and Temperature-Responsive Injectable Adhesive Hydrogels with Polyplexes Promotes Skin Wound Healing

Thai Minh Duy Le et al.

BIOMACROMOLECULES (2018)

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Article Biochemistry & Molecular Biology

Nanochitosan enriched poly epsilon-caprolactone electrospun wound dressing membranes: A fine tuning of physicochemical properties, hemocompatibility and curcumin release profile

C. R. Reshmi et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

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Article Polymer Science

Poly(vinyl alcohol)/chitosan/honey/clay responsive nanocomposite hydrogel wound dressing

S. Noori et al.

JOURNAL OF APPLIED POLYMER SCIENCE (2018)

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Article Polymer Science

pH-Responsive Hybrid Hydrogels as Antibacterial and Drug Delivery Systems

Shabnam Sattari et al.

POLYMERS (2018)

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Article Engineering, Biomedical

Antibacterial adhesive injectable hydrogels with rapid self-healing, extensibility and compressibility as wound dressing for joints skin wound healing

Jin Qu et al.

BIOMATERIALS (2018)

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Article Engineering, Biomedical

A pH-Mediated Electronic Wound Dressing for Controlled Drug Delivery

Gita Kiaee et al.

ADVANCED HEALTHCARE MATERIALS (2018)

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Article Materials Science, Paper & Wood

A multifunctional electrospun and dual nano-carrier biobased system for simultaneous detection of pH in the wound bed and controlled release of benzocaine

Manja Kurecic et al.

CELLULOSE (2018)

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Article Biochemistry & Molecular Biology

Biodegradable and pH Sensitive Peptide Based Hydrogel as Controlled Release System for Antibacterial Wound Dressing Application

Jie Zhu et al.

MOLECULES (2018)

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Review Biotechnology & Applied Microbiology

Wearable Technology for Chronic Wound Monitoring: Current Dressings, Advancements, and Future Prospects

Matthew S. Brown et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2018)

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Review Surgery

Skin Wound Healing: An Update on the Current Knowledge and Concepts

Heiko Sorg et al.

EUROPEAN SURGICAL RESEARCH (2017)

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Article Polymer Science

Biocompatible stimuli responsive superabsorbent polymer for controlled release of GHK-Cu peptide for wound dressing application

Shilpa Sharma et al.

JOURNAL OF POLYMER RESEARCH (2017)

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Article Chemistry, Multidisciplinary

Wound dressing application of pH-sensitive carbon dots/chitosan hydrogel

Meisam Omidi et al.

RSC ADVANCES (2017)

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Article Polymer Science

A pH-Indicating Colorimetric Tough Hydrogel Patch towards Applications in a Substrate for Smart Wound Dressings

Li Liu et al.

POLYMERS (2017)

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Review Dermatology

Measurement of pH, exudate composition and temperature in wound healing: a systematic review

G. Power et al.

JOURNAL OF WOUND CARE (2017)

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Review Multidisciplinary Sciences

A review on polymeric hydrogel membranes for wound dressing applications: PVA-based hydrogel dressings

Elbadawy A. Kamoun et al.

JOURNAL OF ADVANCED RESEARCH (2017)

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Article Nanoscience & Nanotechnology

pH and Glucose Dual-Responsive Injectable Hydrogels with Insulin and Fibroblasts as Bioactive Dressings for Diabetic Wound Healing

Lingling Zhao et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

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Article Chemistry, Multidisciplinary

On-demand Antimicrobial Treatment with Antibiotic-Loaded Porous Silicon Capped with a pH-Responsive Dual Plasma Polymer Barrier

Roshan B. Vasani et al.

CHEMISTRY-AN ASIAN JOURNAL (2017)

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Article Nanoscience & Nanotechnology

Antibacterial and Anti-Inflammatory pH-Responsive Tannic Acid-Carboxylated Agarose Composite Hydrogels for Wound Healing

Neethu Ninan et al.

ACS APPLIED MATERIALS & INTERFACES (2016)

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Article Engineering, Chemical

Preparation, antibacterial activity and pH-responsive release behavior of silver sulfadiazine loaded bacterial cellulose for wound dressing applications

Wei Shao et al.

JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS (2016)

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Article Multidisciplinary Sciences

Local Application of Probiotic Bacteria Prophylaxes against Sepsis and Death Resulting from Burn Wound Infection

Anne Argenta et al.

PLOS ONE (2016)

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Review Dermatology

Traditional Therapies for Skin Wound Healing

Ruben F. Pereira et al.

ADVANCES IN WOUND CARE (2016)

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Review Dermatology

Approach to chronic wound infections

D. Leaper et al.

BRITISH JOURNAL OF DERMATOLOGY (2015)

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Article Biochemistry & Molecular Biology

pH-responsive release behavior and anti-bacterial activity of bacterial cellulose-silver nanocomposites

Wei Shao et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2015)

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Article Polymer Science

In Vitro Study of Temperature and pH-Responsive Gentamycin Sulphate-Loaded Chitosan-Based Hydrogel Films for Wound Dressing Applications

Mohammad Amir Qureshi et al.

POLYMER-PLASTICS TECHNOLOGY AND ENGINEERING (2015)

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Review Biochemistry & Molecular Biology

Electrospun Nanofibers as Dressings for Chronic Wound Care: Advances, Challenges, and Future Prospects

Martina Abrigo et al.

MACROMOLECULAR BIOSCIENCE (2014)

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Review Dermatology

Skin Wound Healing and Phytomedicine: A Review

Nader Pazyar et al.

SKIN PHARMACOLOGY AND PHYSIOLOGY (2014)

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Review Cell Biology

The effects of pH on wound healing, biofilms, and antimicrobial efficacy

Steven L. Percival et al.

WOUND REPAIR AND REGENERATION (2014)

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Article Dermatology

Honey and Wound Healing An Overview

David S. Lee et al.

AMERICAN JOURNAL OF CLINICAL DERMATOLOGY (2011)

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Article Materials Science, Textiles

The Preparation of Polyurethane Foam Combined with pH-sensitive Alginate/Bentonite Hydrogel for Wound Dressings

Seung-Taek Oh et al.

FIBERS AND POLYMERS (2011)

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Review Dentistry, Oral Surgery & Medicine

Factors Affecting Wound Healing

S. Guo et al.

JOURNAL OF DENTAL RESEARCH (2010)

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Article Dermatology

Assessment and management of persistent (chronic) and total wound pain

Kevin Woo et al.

INTERNATIONAL WOUND JOURNAL (2008)

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Review Dermatology

Influence of pH on wound-healing: a new perspective for wound-therapy?

Lars Alexander Schneider et al.

ARCHIVES OF DERMATOLOGICAL RESEARCH (2007)

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Review Dermatology

Inflammation in wound repair: Molecular and cellular mechanisms

Sabine A. Eming et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2007)

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Review Surgery

Inflammation in surgical wound healing: Friend or foe?

AM Szpaderska et al.

SURGERY (2005)

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Article Engineering, Biomedical

Electrospun nanofibrous polyurethane membrane as wound dressing

MS Khil et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2003)

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