Anti-inflammatory constituents isolated from the flowers of Hosta plantaginea via suppression of the NF-kB signaling pathway in LPS-stimulated RAW 264.7 macrophages

Article Plant Sciences

Hostaflavone A from Hosta plantaginea (Lam.) Asch. blocked NF-κB/iNOS/ COX-2/MAPKs/Akt signaling pathways in LPS-induced RAW 264.7 macrophages

Li Yang et al.

Summary: Hostaflavone A (HA), a new flavonoid component isolated from Hosta plantaginea (Lam.) Asch. flower, shows anti-inflammatory effects by inhibiting NF-kappa B, iNOS, COX-2, MAPKs, and Akt pathways in RAW 264.7 cells activated by LPS.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Medicine, Research & Experimental

Kaempferol 3-O-(2G-glucosylrutinoside)-7-O-glucoside isolated from the flowers of Hosta plantaginea exerts anti-inflammatory activity via suppression of NF-?B, MAPKs and Akt pathways in RAW 264.7 cells

Yiwei Fang et al.

Summary: This study explored the anti-inflammatory effect and potential molecular mechanisms of Kaempferol 3-O-(2(G)-glucosylrutinoside)-7-O-glucoside (KGG) in cells. KGG inhibited the secretion of inflammatory mediators and attenuated the activation of NF-kappa B, MAPKs, and Akt signaling pathways.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Article Integrative & Complementary Medicine

Anti-inflammatory effects of flavonoids and phenylethanoid glycosides from Hosta plantaginea flowers in LPS-stimulated RAW 264.7 macrophages through inhibition of the NE-κB signaling pathway

Li Yang et al.

Summary: Compounds 1, 4-6, 15, and 17 from the flower of Hosta plantaginea have anti-inflammatory effects by blocking the NF-κB signaling pathway and suppressing the overproduction of inflammatory mediators, which may be helpful in managing inflammatory diseases.

BMC COMPLEMENTARY MEDICINE AND THERAPIES (2022)

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Article Chemistry, Applied

Plantanone D, a new rare methyl-flavonoid from the flowers of Hosta plantaginea with anti-inflammatory and antioxidant activities

Li Yang et al.

Summary: In this study, a new rare methyl-flavonoid and a known compound were isolated and characterized from the flowers of Hosta plantaginea. The new compound exhibited significant anti-inflammatory activities and antioxidant activities, making it a potential candidate for further research and development in the treatment of inflammation-related diseases.

NATURAL PRODUCT RESEARCH (2021)

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Article Medicine, Research & Experimental

Plantanone C attenuates LPS-stimulated inflammation by inhibiting NF-κB/iNOS/COX-2/MAPKs/Akt pathways in RAW 264.7 macrophages

Yiwei Fang et al.

Summary: Plantanone C from Hosta plantaginea flowers shows anti-inflammatory effects in RAW 264.7 macrophages by inhibiting NF-kappa B, iNOS, COX-2, MAPKs, and Akt signaling pathways.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Review Plant Sciences

Traditional uses, phytochemistry, pharmacology and toxicological aspects of the genus Hosta (Liliaceae): A comprehensive review

Li Yang et al.

Summary: Hosta species are valuable plants rich in steroids and flavonoids, known for their anti-inflammatory, analgesic, and antioxidant properties. However, gaps in understanding traditional uses exist, requiring further high-quality research to assess safety and efficacy.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Review Chemistry, Medicinal

An Updated Review of Various Medicinal Applications of p-Coumaric Acid: From Antioxidative and Anti-inflammatory Properties to Effects on Cell Cycle and Proliferation

Mohammad Foad Abazari et al.

Summary: P-Coumaric acid (p-CA) is a natural compound found in various edible plants with therapeutic properties. Recent studies have shown that p-CA may have beneficial effects on diseases such as nephropathies, cardiovascular diseases, neuroinflammatory diseases, liver diseases, cancers, and metabolic disorders. Autophagy is a novel molecular mechanism that plays a role in the therapeutic effects of p-CA. Further research is needed to clarify the main therapeutic properties of p-CA and explore its mechanisms of action.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2021)

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Article Cell Biology

Compounds DRG and DAG, Two Phenol Glycosides, Inhibit TNF-α-stimulated Inflammatory Response through Blocking NF-kB/AKT/JNK Signaling Pathways in MH7A Cells

Li Yang et al.

Summary: The study isolated fourteen constituents from Dendropanax dentiger roots, two of which, DRG and DAG, were found to significantly inhibit TNF-alpha-induced inflammatory response in human RA fibroblast-like synoviocytes by blocking the NF-kB/AKT/JNK signaling pathway at a concentration of 10 μM. This suggests that DRG and DAG may hold promise as potential therapeutics against RA and other inflammation-related conditions.

INFLAMMATION (2021)

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Article Immunology

Anti-inflammatory effect of phenylpropanoids from Dendropanax dentiger in TNF-α-induced MH7A cells via inhibition of NF-κB, Akt and JNK signaling pathways

Li Yang et al.

Summary: The study found that phenylpropanoids from the root extract of Dendropanax dentiger have potential anti-rheumatoid arthritis effects, with compounds like pinoresinol and dendrocoumarin A showing significant inhibitory effects on NO production and modulation of cytokines and signaling pathways to reduce inflammation.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Article Immunology