期刊
CLINICS IN DERMATOLOGY
卷 33, 期 1, 页码 108-115出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.clindermatol.2014.07.001
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- Department of Health and Humans Services, Health Resources and Services Administration's, Healthcare systems Bureau, National Hansen's Disease Program
- National Institute of Allergy and Infectious Diseases [NIAID IAA-2646]
Apart from humans, armadillos are the only known natural hosts of Mycobacterium leprae. They are well developed as hosts for in vivo propagation of M leprae and are advancing as models for studying the pathogenesis of leprosy and translational research. Armadillos are immunologically intact. They exhibit the full Ridley-Jopling spectrum of histopathologic responses to M leprae and uniquely manifest extensive neurological involvement that closely recapitulates human leprosy. In addition, free-ranging armadillos in some regions are known to harbor a naturally occurring infection with M leprae, and zoonotic transmission between armadillos and humans has been implicated in a large number of new case presentations. We review the role of the armadillo as a model for leprosy and reservoir for human infection. Published by Elsevier Inc.
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