4.6 Article

A mechanistic study of thiol addition to N-acryloylpiperidine

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Organic

A mechanistic study of thiol addition to N-phenylacrylamide

Sarah K. Watt et al.

Summary: This study provides a detailed mechanism of the reaction between acrylamide and cysteine, which is important for the development of targeted enzyme inhibitors.

ORGANIC & BIOMOLECULAR CHEMISTRY (2022)

Article Pharmacology & Pharmacy

Clinical pharmacology and PK/PD translation of the second-generation Bruton's tyrosine kinase inhibitor, zanubrutinib

Constantine S. Tam et al.

Summary: Zanubrutinib, a BTK inhibitor, exhibits less susceptibility to modulation by intrinsic and extrinsic factors compared to other similar drugs, leading to more consistent therapeutic exposures and improved dosing convenience. Clinical studies have shown that the pharmacokinetics and pharmacodynamics of zanubrutinib translate into durable treatment responses, providing an important new option for patients in need of BTK therapy.

EXPERT REVIEW OF CLINICAL PHARMACOLOGY (2021)

Article Chemistry, Multidisciplinary

Quantum Chemical Methods for Modeling Covalent Modification of Biological Thiols

Ernest Awoonor-Williams et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2020)

Article Chemistry, Medicinal

Systematic Study of the Glutathione Reactivity of N-Phenylacrylamides: 2. Effects of Acrylamide Substitution

Adam Birkholz et al.

JOURNAL OF MEDICINAL CHEMISTRY (2020)

Article Chemistry, Organic

Mechanisms of Alkyl and Aryl Thiol Addition to N-Methylmaleimide

Mark A. R. Raycroft et al.

JOURNAL OF ORGANIC CHEMISTRY (2018)

Article Chemistry, Medicinal

Systematic Study of the Glutathione (GSH) Reactivity of N-Arylacrylamides: 1. Effects of Aryl Substitution

Victor J. Cee et al.

JOURNAL OF MEDICINAL CHEMISTRY (2015)

Article Medicine, General & Internal

Resistance Mechanisms for the Bruton's Tyrosine Kinase Inhibitor Ibrutinib

Jennifer A. Woyach et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Chemistry, Physical

Range-Separated DFT Functionals are Necessary to Model Thio-Michael Additions

Jennifer M. Smith et al.

JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2013)

Article Medicine, General & Internal

Targeting BTK with Ibrutinib in Relapsed Chronic Lymphocytic Leukemia

John C. Byrd et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Chemistry, Physical

Long-range corrected hybrid density functionals with damped atom-atom dispersion corrections

Jeng-Da Chai et al.

PHYSICAL CHEMISTRY CHEMICAL PHYSICS (2008)