期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 71, 期 5, 页码 2197-2210出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.2c068882197
关键词
yeast; Saccharomyces cerevisiae; metabolic engineering; synthetic biology; triterpenoids; plant natural products
Plant natural products are a valuable source of novel chemical structures. However, their extraction can be expensive and result in fluctuation in quantity and quality, as well as negative environmental impact. Synthetic biology has enabled the production of natural plant products using yeasts as hosts.
Plant natural products are a seemingly endless resource for novel chemical structures. However, their extraction often results in high prices, fluctuation in both quantity and quality, and negative environmental impact. The latter might result from the extraction procedure but more often from the high amount of plant biomass required. With the advent of synthetic biology, producing natural plant products in large quantities using yeasts as hosts has become possible. Here, we focus on the recent advances in metabolic engineering of the yeasts species Saccharomyces cerevisiae and Yarrowia lipolytica for the synthesis of ginsenoside ginsenoside Rg3, and ginsenoside F1. A discussion is provided on advanced synthetic biology, bioprocess strategies, and current challenges for the biosynthesis of ginsenoside triterpenoids. Finally, future directions in metabolic and process engineering are summarized and may help reify sustainable ginsenoside production.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据