期刊
CURRENT ONCOLOGY
卷 30, 期 2, 页码 1954-1976出版社
MDPI
DOI: 10.3390/curroncol30020152
关键词
CRISPR; Cas; advanced technologies; advanced therapeutics; cancer; cancer treatment; oncoviruses; clinical trials
类别
Gene editing, especially with CRISPR-Cas9, has advanced gene function science and its medical/clinical value. CRISPR/Cas9's specificity and efficiency simplify disease-specific gene therapy. In recent years, tumor treatment research has increasingly employed CRISPR/Cas9 for targeted gene-level therapy.
Gene editing, especially with clustered regularly interspaced short palindromic repeats associated protein 9 (CRISPR-Cas9), has advanced gene function science. Gene editing's rapid advancement has increased its medical/clinical value. Due to its great specificity and efficiency, CRISPR/Cas9 can accurately and swiftly screen the whole genome. This simplifies disease-specific gene therapy. To study tumor origins, development, and metastasis, CRISPR/Cas9 can change genomes. In recent years, tumor treatment research has increasingly employed this method. CRISPR/Cas9 can treat cancer by removing genes or correcting mutations. Numerous preliminary tumor treatment studies have been conducted in relevant fields. CRISPR/Cas9 may treat gene-level tumors. CRISPR/Cas9-based personalized and targeted medicines may shape tumor treatment. This review examines CRISPR/Cas9 for tumor therapy research, which will be helpful in providing references for future studies on the pathogenesis of malignancy and its treatment.
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