期刊
JOURNAL OF TISSUE ENGINEERING
卷 14, 期 -, 页码 -出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/20417314231151826
关键词
Tissue engineering; trachea decellularization; extracellular matrix; orthotopic implant
Severe tracheal injuries pose a challenge in surgical practice, but decellularized scaffolds provide a potential solution. This systematic review examines studies on decellularized/bioengineered tracheal implantation, including orthotopic implant results and clinical cases.
Severe tracheal injuries that cannot be managed by mobilization and end-to-end anastomosis represent an unmet clinical need and an urgent challenge to face in surgical practice; within this scenario, decellularized scaffolds (eventually bioengineered) are currently a tempting option among tissue engineered substitutes. The success of a decellularized trachea is expression of a balanced approach in cells removal while preserving the extracellular matrix (ECM) architecture/mechanical properties. Revising the literature, many Authors report about different methods for acellular tracheal ECMs development; however, only few of them verified the devices effectiveness by an orthotopic implant in animal models of disease. To support translational medicine in this field, here we provide a systematic review on studies recurring to decellularized/bioengineered tracheas implantation. After describing the specific methodological aspects, orthotopic implant results are verified. Furtherly, the only three clinical cases of compassionate use of tissue engineered tracheas are reported with a focus on outcomes.
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