Urinary microRNA in Diabetic Kidney Disease: A Literature Review

Diabetic kidney disease is the most common primary disease of end-stage kidney disease globally; however, a sensitive and accurate biomarker to predict this disease remains awaited. microRNAs are endogenous single-stranded noncoding RNAs that have intervened in different post-transcriptional regulations of various cellular biological functions. Previous literatures have reported its potential role in the pathophysiology of diabetic kidney disease, including regulation of Transforming Growth Factor-beta 1-mediated fibrosis, extracellular matrix and cell adhesion proteins, cellular hypertrophy, growth factor, cytokine production, and redox system activation. Urinary microRNAs have emerged as a novel, non-invasive liquid biopsy for disease diagnosis. In this review, we describe the available experimental and clinical evidence of urinary microRNA in the context of diabetic kidney disease and discuss the future application of microRNA in routine practice.

Automated summary

Diabetic kidney disease is a common primary disease of end-stage kidney disease, but there is currently no sensitive and accurate biomarker to predict it. microRNAs, which are noncoding RNAs, have been reported to play a potential role in the pathophysiology of diabetic kidney disease. Urinary microRNAs have emerged as a novel, non-invasive liquid biopsy for disease diagnosis. This review discusses the experimental and clinical evidence of urinary microRNA in the context of diabetic kidney disease and explores its future application in routine practice.