Quercetin Inhibits Intrahepatic Cholangiocarcinoma by Inducing Ferroptosis and Inhibiting Invasion via the NF-κB Pathway

Article Immunology

Lupeol triggers oxidative stress, ferroptosis, apoptosis and restrains inflammation in nasopharyngeal carcinoma via AMPK/NF-κB pathway

Jing-Chun Zhou et al.

Summary: This study found that lupeol has anti-cancer effects in nasopharyngeal carcinoma, by inducing oxidative stress, ferroptosis, and apoptosis, as well as suppressing inflammation via the AMPK/NF-κB pathway.

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY (2022)

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Article Integrative & Complementary Medicine

Activation of p62-NRF2 Axis Protects against Doxorubicin-Induced Ferroptosis in Cardiomyocytes: A Novel Role and Molecular Mechanism of Resveratrol

Wei Yu et al.

Summary: Doxorubicin, a common chemotherapeutic agent, has limited clinical efficacy due to its severe cardiotoxicity. Resveratrol, known for its antioxidative and anti-inflammatory properties, protects cardiomyocytes by inhibiting ferroptosis induced by doxorubicin. This study reveals that resveratrol activates the p62-NRF2/HO-1 pathway and suppresses mitochondrial reactive oxygen species, thereby preventing ferroptosis in cardiomyocytes.

AMERICAN JOURNAL OF CHINESE MEDICINE (2022)

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Article Immunology

MiR-93-5p promotes granulosa cell apoptosis and ferroptosis by the NF-kB signaling pathway in polycystic ovary syndrome

Wei Tan et al.

Summary: This study found that miR-93-5p is upregulated in the granulosa cells of PCOS patients and promotes apoptosis and ferroptosis in these cells by negatively regulating the NF-kappa B signaling pathway. Silencing miR-93-5p can protect granulosa cell function, which is of great significance for improving the function of granulosa cells in PCOS patients.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Pharmacology & Pharmacy

Quercetin induces p53-independent cancer cell death through lysosome activation by the transcription factor EB and Reactive Oxygen Species-dependent ferroptosis

Zi-Xuan Wang et al.

Summary: The study demonstrated that quercetin induces ferroptosis and apoptosis by modulating lysosome function and iron metabolism, suggesting its potential as an anti-cancer agent.

BRITISH JOURNAL OF PHARMACOLOGY (2021)

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Article Engineering, Biomedical

Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy

Boyi Niu et al.

Summary: Glutathione (GSH) plays a crucial role in cellular antioxidative system, particularly in cancer cells, where a high level of GSH is essential for scavenging ROS and detoxifying xenobiotics. Depletion of GSH has been shown to enhance the efficacy of various therapies such as ROS-based therapy, ferroptosis, and chemotherapy. This review comprehensively discusses the importance of GSH depletion in cancer therapy and various strategies employed to achieve it.

BIOMATERIALS (2021)

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Article Neurosciences

LPS Preconditioning Attenuates Apoptosis Mechanism by Inhibiting NF-κB and Caspase-3 Activity: TLR4 Pre-activation in the Signaling Pathway of LPS-Induced Neuroprotection

Pushpa Gandi Sangaran et al.

Summary: Neuroinflammation plays a key role in the progression of various neurodegenerative diseases, and recent studies have shown that LPS preconditioning provides neuroprotection by activating TLR4. Pre-exposure to low dose of LPS can confer a protective state against cellular apoptosis, indicating a role for TLR4 pre-activation in the signaling pathway of LPS-induced neuroprotection.

MOLECULAR NEUROBIOLOGY (2021)

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Article Biochemical Research Methods

Crystal structures of the selenoprotein glutathione peroxidase 4 in its apo form and in complex with the covalently bound inhibitor ML162

Dieter Moosmayer et al.

Summary: Wild-type human glutathione peroxidase 4 (GPX4) was efficiently produced in human HEK cells with the co-expression of SBP2, leading to the determination of its crystal structure at 1.0 angstrom resolution. A mass-spectrometry-based approach was developed to monitor the reaction of the active-site selenocysteine with covalent inhibitors, enabling the determination of the crystal structure of GPX4 in complex with the covalent inhibitor ML162 [(S)-enantiomer]. This approach opens the possibility for further crystal structures of GPX4 in complex with potential cancer drug targets.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2021)

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Article Integrative & Complementary Medicine

Quercetin Induces Apoptosis in Glioblastoma Cells by Suppressing Axl/IL-6/STAT3 Signaling Pathway

Hyo In Kim et al.

Summary: This study found that quercetin can induce apoptosis in GBM cells by inhibiting the Axl/IL-6/STAT3 signaling pathway, suggesting its potential as an anticancer agent.

AMERICAN JOURNAL OF CHINESE MEDICINE (2021)

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Review Pharmacology & Pharmacy

Recent progress on targeting ferroptosis for cancer therapy

Guangxiang Xu et al.

Summary: Ferroptosis is a novel mode of cell death that has become a target for antitumor therapy. Research has identified various mechanisms regulating the sensitivity of cancer cells to ferroptosis, and progress has been made in exploring ferroptosis-related drugs.

BIOCHEMICAL PHARMACOLOGY (2021)

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Article Gastroenterology & Hepatology

Comparison of Clinical Features and Outcomes Between Intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma in the United States

Yi-Te Lee et al.

Summary: This study investigated the differences in clinical features and outcomes between intrahepatic cholangiocarcinoma (iCCA) and hepatocellular carcinoma (HCC) using a large-scale database. Despite iCCA patients presenting at an advanced stage, the overall survival (OS) was similar between iCCA and HCC in multivariable analysis, with some subgroups of iCCA showing longer OS.

HEPATOLOGY (2021)

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Article Biotechnology & Applied Microbiology

Quercetin against MCF7 and CAL51 breast cancer cell lines: apoptosis, gene expression, and cytotoxicity of nano-quercetin

Hamdoon A. Mohammed et al.

Summary: The study demonstrates the potential anti-breast cancer efficacy of Q-PLGA-NPs, showing their ability to kill breast cancer cells and lack of toxicity in mice.

NANOMEDICINE (2021)

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Article Immunology

Glutathione peroxidase 4-regulated neutrophil ferroptosis induces systemic autoimmunity

Pengchong Li et al.

Summary: This study identifies a role for GPX4-regulated ferroptosis in neutrophils from SLE patients, triggered by interferons and autoreactive antibodies, contributing to lupus pathogenesis. The mechanism involves enhanced binding of a transcriptional repressor to the Gpx4 promoter leading to elevated lipid-reactive oxygen species. Neutrophil ferroptosis is shown to be a significant driver of neutropenia in SLE and heavily contributes to disease manifestations.

NATURE IMMUNOLOGY (2021)

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Article Chemistry, Multidisciplinary

Quercetin-Loaded Ceria Nanocomposite Potentiate Dual-Directional Immunoregulation via Macrophage Polarization against Periodontal Inflammation

Yu Wang et al.

Summary: Introducing the antioxidant drug quercetin onto nano-octahedral ceria enables synergistic modulation of host immunity against periodontal disease, promoting M2 polarization and tissue regeneration. The nanocomposite shows significant therapeutic potential against periodontal disease by effectively controlling macrophage polarization.

SMALL (2021)

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Article Biology