Deoxynivalenol induces intestinal injury: insights from oxidative stress and intestinal stem cells

Mycotoxins are fungal secondary metabolites that frequently occur in human and animal diets. Deoxynivalenol (DON) is one of the most widely occurring mycotoxins globally and poses significant harm to the animal husbandry industry and human health. People are increasingly aware of the adverse effects of DON on vulnerable structures and functions in the intestine, especially in the field of intestinal stem cells (ISCs). In this review, we present insights into DON that induces oxidative stress and affects the expansion of ISCs. Related studies of strategies for reducing its harm are summarized. We also discussed promising approaches such as regulation of microbiota, molecular docking, and modulation of the redox status via reducing the expression of Keap1 protein and single-cell sequencing, which may be critical for further revealing the mechanism of DON that induces oxidative stress and affects the expansion of ISCs.

Automated summary

This review provides insights into the presence and harmful effects of deoxynivalenol (DON), one of the most widely occurring mycotoxins, on the animal husbandry industry and human health. It focuses on the adverse effects of DON on intestinal stem cells (ISCs) and how it induces oxidative stress. Strategies for reducing the harm of DON are summarized, including the regulation of microbiota, molecular docking, and modulation of the redox status through the manipulation of Keap1 protein expression and single-cell sequencing.