4.3 Review

Secondary diabetes mellitus in acromegaly

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Summary: This study evaluated the efficacy of pasireotide-LAR in acromegaly patients resistant to first-generation SRLs, finding that some patients achieved complete biochemical control while most showed clinical improvement. However, significant worsening of glucose metabolism was noted in some patients.

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Summary: Weight gain post-surgery is common in patients with acromegaly, and diabetes mellitus at the time of diagnosis is a significant predictor of weight and fat gain post-surgery.

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Summary: This study suggests that the presence of diabetes in patients with acromegaly is associated with increased overall mortality, cardiovascular mortality, and morbidity.

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Acromegaly: pathogenesis, diagnosis, and management

Maria Fleseriu et al.

Summary: Acromegaly, caused by growth hormone-secreting pituitary adenomas, is usually benign but can be locally invasive and progressive. It leads to a wide range of comorbidities and the normalization of growth hormone and insulin-like growth factor 1 is the primary therapeutic goal. A multimodal approach with surgery, medical therapy, and radiation therapy is required for optimal outcomes.

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HOMA-IR in acromegaly: a systematic review and meta-analysis

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Summary: HOMA-IR levels are higher in treatment-naive ACRO patients compared to the reference population, even in those without diabetes. Treatment with surgery or SSAs significantly reduces HOMA-IR levels, but SSAs do not improve basal glucose levels.

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Possible protective role of metformin therapy on colonic polyps in acromegaly: an exploratory cross-sectional study

M Albertelli et al.

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Prevalence and outcome of comorbidities associated with acromegaly

Sven Berkmann et al.

Summary: This study evaluated the prevalence and course of hypertension, obesity, diabetes mellitus, obstructive sleep apnea syndrome, carpal tunnel syndrome, and polyposis coli in acromegalic patients. Surgical treatment led to remission in some patients, while drug therapy was more effective, but many comorbidities persisted.

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Managing pasireotide-associated hyperglycemia: a randomized, open-label, Phase IV study

Susan L. Samson et al.

Summary: Pasireotide is effective for acromegaly and Cushing's disease, but may cause hyperglycemia. This study compared incretin-based therapy with insulin for managing pasireotide-associated hyperglycemia, finding that most patients do not require oral antidiabetic drugs and metformin is an effective initial treatment.

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Sodium glucose cotransporter 2 inhibitors treatment in acromegalic patients with diabetes-a case series and literature review

Adnan Zaina et al.

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Glucose Abnormalities Associated to Prolactin Secreting Pituitary Adenomas

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Total adiponectin in overweight and obese subjects and its response to visceral fat loss

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Disposition Index in Active Acromegaly

Dan Alexandru Niculescu et al.

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Sodium Glucose Co-transporter Inhibitors in Patients with Acromegaly and Diabetes

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Persistence of Diabetes and Hypertension After Multimodal Treatment of Acromegaly

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Impact of Long-Acting Somatostatin Analogues on Glucose Metabolism in Acromegaly: A Hospital-Based Study

Ming Shen et al.

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Insulin-Like Growth Factor-1 at Diagnosis and during Subsequent Years in Adolescents with Type 1 Diabetes

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Marked alteration of glycemic profile surrounding lanreotide administration in acromegaly: A case report

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Comorbidities, treatment patterns and cost-of-illness of acromegaly in Sweden: a register-linkage population-based study

Eva Lesen et al.

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Acromegaly at diagnosis in 3173 patients from the Liege Acromegaly Survey (LAS) Database

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Rapid Onset of Diabetic Ketoacidosis After SGLT2 Inhibition in a Patient With Unrecognized Acromegaly

Marino Quarella et al.

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Diabetic ketoacidosis in acromegaly; a rare complication precipitated by corticosteroid use

Jeremy Weiss et al.

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The modulation of adiponectin by STAT5-activating hormones

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Acromegaly incidence, prevalence, complications and long-term prognosis: a nationwide cohort study

Jakob Dal et al.

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Kentaro Suda et al.

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Dopaminergic drugs in type 2 diabetes and glucose homeostasis

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Monotherapy with lanreotide depot for acromegaly: long-term clinical experience in a pituitary center

Babak Torabi Sagvand et al.

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The Impact of Adipose Tissue on Insulin Resistance in Acromegaly

Nicoleta Cristina Olarescu et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2016)

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Current and Emerging Aspects of Diabetes Mellitus in Acromegaly

Stefano Frara et al.

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The prevalence of acromegaly in hospitalized patients with type 2 diabetes

Kentaro Suda et al.

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Adipose Tissue Redistribution and Ectopic Lipid Deposition in Active Acromegaly and Effects of Surgical Treatment

Carlos M. Reyes-Vidal et al.

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GH Receptor Deficiency in Ecuadorian Adults Is Associated With Obesity and Enhanced Insulin Sensitivity

Jaime Guevara-Aguirre et al.

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The Role of Diabetes in Acromegaly Associated Neoplasia

Sonia Cheng et al.

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Diagnosis and Classification of Diabetes Mellitus

DIABETES CARE (2014)

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Investigational drugs targeting somatostatin receptors for treatment of acromegaly and neuroendocrine tumors

Andrea Giustina et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2014)

Article Endocrinology & Metabolism

Pasireotide Versus Octreotide in Acromegaly: A Head-to-Head Superiority Study

A. Colao et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2014)

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Prevalence of diabetes mellitus in patients with acromegaly

A. V. Dreval et al.

ENDOCRINE CONNECTIONS (2014)

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Suppression of Primary Aldosteronism and Resistant Hypertension by the Peroxisome Proliferator-activated Receptor Gamma Agonist Pioglitazone

Yusuke Kashiwagi et al.

AMERICAN JOURNAL OF THE MEDICAL SCIENCES (2013)

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Emerging trends in the diagnosis and treatment of acromegaly in Canada

Sophie Vallette et al.

CLINICAL ENDOCRINOLOGY (2013)

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Ketoacidosis as the initial clinical condition in nine patients with acromegaly: a review of 860 cases at a single institute

Naohiro Yoshida et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2013)

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The Metabolic Profile in Active Acromegaly is Gender-Specific

A. Ciresi et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2013)

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Hyperglycemia Associated With Pasireotide: Results From a Mechanistic Study in Healthy Volunteers

Robert R. Henry et al.

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Diabetic Ketoacidosis in Acromegaly: A Case Report

Pilaiporn Palakawong et al.

Endocrine Practice (2012)

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Adipocytes as a Source of Increased Circulating Levels of Nicotinamide Phosphoribosyltransferase/Visfatin in Active Acromegaly

Nicoleta C. Olarescu et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2012)

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Diabetes in acromegaly, prevalence, risk factors, and evolution: data from the French Acromegaly Registry

Sandrine Fieffe et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2011)

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Influence of diabetes mellitus on vertebral fractures in men with acromegaly

Gherardo Mazziotti et al.

ENDOCRINE (2011)

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Effects of Growth Hormone on Glucose, Lipid, and Protein Metabolism in Human Subjects

Niels Moller et al.

ENDOCRINE REVIEWS (2009)

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Glucose Tolerance and Somatostatin Analog Treatment in Acromegaly: A 12-Month Study

Annamaria Colao et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2009)

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Pegvisomant Improves Insulin Sensitivity and Reduces Overnight Free Fatty Acid Concentrations in Patients with Acromegaly

C. E. Higham et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2009)

Review Endocrinology & Metabolism

Effects of Somatostatin Analogs on Glucose Homeostasis: A Metaanalysis of Acromegaly Studies

Gherardo Mazziotti et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2009)

Article Endocrinology & Metabolism

Low serum IGF-I/GH ratio is associated with abnormal glucose tolerance in acromegaly

Hidenori Fukuoka et al.

HORMONE RESEARCH (2008)

Article Multidisciplinary Sciences

Reduced Basal ATP Synthetic Flux of Skeletal Muscle in Patients with Previous Acromegaly

Julia Szendroedi et al.

PLOS ONE (2008)

Article Endocrinology & Metabolism

Effects of growth hormone on the function of β-adrenoceptor subtypes in rat adipocytes

SM Yang et al.

OBESITY RESEARCH (2004)

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A case of secondary diabetes mellitus with acromegaly improved by pioglitazone

A Watanabe et al.

DIABETIC MEDICINE (2004)

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Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient mice

S Yakar et al.

JOURNAL OF CLINICAL INVESTIGATION (2004)

Article Medicine, Research & Experimental

PPAR-γ receptor ligands:: novel therapy for pituitary adenomas

AP Heaney et al.

JOURNAL OF CLINICAL INVESTIGATION (2003)

Article Medicine, Research & Experimental

Defective insulin secretion in pancreatic β cells lacking type 1 IGF receptor

SH Xuan et al.

JOURNAL OF CLINICAL INVESTIGATION (2002)

Article Biochemistry & Molecular Biology

Secretion of adiponectin and regulation of apM1 gene expression in human visceral adipose tissue

CM Halleux et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)

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Risk factors for glucose intolerance in active acromegaly

A Kreze et al.

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH (2001)

Article Endocrinology & Metabolism

Liver-specific igf-1 gene deletion leads to muscle insulin insensitivity

S Yakar et al.

DIABETES (2001)

Article Endocrinology & Metabolism

Regulation of β-cell mass by hormones and growth factors

JH Nielsen et al.

DIABETES (2001)

Article Endocrinology & Metabolism

Bromocriptine - A novel approach to the treatment of type 2 diabetes

H Pijl et al.

DIABETES CARE (2000)