期刊
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
卷 44, 期 10, 页码 713-729出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/13803395.2023.2183937
关键词
Prosaccade; stimulus; eccentricity; alzheimer's disease; mild cognitive impairment
The study aimed to investigate prosaccade stimulus eccentricity and compare prosaccade parameters in patients with AD, aMCI, and NA. The results showed that patients with AD had lower correct saccade rates and longer latencies than NA. Patients with aMCI did not differ in prosaccade performance compared to NA. Prosaccade parameters were significantly correlated with all cognitive domains.
Introduction: Prosaccade task is a widely used objective method to evaluate reflexive saccade and visual attention. The study aimed to investigate prosaccade stimulus eccentricity, compare prosaccade parameters in patients with Alzheimer's disease dementia (AD), amnestic mild cognitive impairment (aMCI), and neurotypical adults (NA), and examine the relationship between prosaccade and neuropsychological tests. Methods: Thirty patients with AD, 34 with aMCI, and 32 NA were included in the study. Eye movements were recorded with the EyeLink 1000 Plus in the prosaccade task, and this study evaluated cognitive function with comprehensive neuropsychological tests assessing attention, memory, executive function, visuospatial function, and language domains. Results: The correct saccade rates of patients with AD were significantly lower than NA in the 5 degrees and 10 degrees stimulus eccentricities. Patients with AD had significantly longer latencies in the 10 degrees stimulus eccentricity than those with aMCI and NA. Patients with aMCI did not differ in prosaccade performance compared to NA. Prosaccade parameters were significantly correlated with all cognitive domains. As the amplitude of the stimuli increased, the rate of correct saccades decreased, while the express saccade rate, latency, amplitude, and peak velocity increased. Conclusion: Our findings that correct saccade rates and latency may be distinguishing parameters of early AD are promising. This study also found that stimulus eccentricity affects prosaccade measures in AD, MCI, and NA.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据