SARS-CoV-2 spike protein induces IL-18-mediated cardiopulmonary inflammation via reduced mitophagy

Article Allergy

IL-6 serum levels predict severity and response to tocilizumab in COVID-19: An observational study

Jose Maria Galvan-Roman et al.

Summary: Baseline IL-6 greater than 30 pg/mL predicts the need for IMV in COVID-19 patients, and early TCZ treatment can improve oxygenation. Patients with high IL-6 not treated with TCZ show high mortality.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Review Cell Biology

IL-18 and infections: Is there a role for targeted therapies?

Alessandra Vecchie et al.

Summary: IL-18 is a pro-inflammatory cytokine that regulates immune responses by influencing Th1 and Th2 reactions. It may play a role in cytokine storms and could be a potential therapeutic target in diseases like COVID-19.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

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Review Cell Biology

Aging in COVID-19: Vulnerability, immunity and intervention

Yiyin Chen et al.

Summary: The COVID-19 pandemic originating from Wuhan in December 2019 has had far-reaching health and socioeconomic impacts worldwide. The disease caused by SARS-CoV-2 is highly heterogeneous, with age, gender, and comorbidities playing key roles in disease severity and outcomes. Aging and dysregulation of immune function are thought to contribute to the increased vulnerability of older adults to severe COVID-19. Further research on immune responses to SARS-CoV-2 infection, particularly in different age groups, is crucial for understanding disease heterogeneity and developing effective vaccines.

AGEING RESEARCH REVIEWS (2021)

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Article Biochemistry & Molecular Biology

Prognostic value of interleukin-18 and its association with other inflammatory markers and disease severity in COVID-19

Hasan Satis et al.

Summary: This study investigated the association of IL-18 with other inflammatory markers in COVID-19 patients, finding that serum IL-18 levels correlate with disease severity and higher levels are associated with worse outcomes.

CYTOKINE (2021)

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Article Immunology

Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients

Tamara S. Rodrigues et al.

Summary: The active NLRP3 inflammasome in response to SARS-CoV-2 infection is associated with disease severity in COVID-19 patients, with higher levels of IL-18 and Casp1p20 correlating with poor clinical outcomes. These findings suggest that inflammasomes may serve as markers of disease severity and potential therapeutic targets for COVID-19.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

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Article Neurosciences

ACE-2-interacting Domain of SARS-CoV-2 (AIDS) Peptide Suppresses Inflammation to Reduce Fever and Protect Lungs and Heart in Mice: Implications for COVID-19 Therapy

Ramesh K. Paidi et al.

Summary: Research has shown that designing an AIDS peptide to interfere with the binding of SARS-CoV-2 to ACE2 can inhibit viral activity in lung cells and have a protective effect on COVID-19 symptoms.

JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2021)

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Article Pharmacology & Pharmacy

Endothelial cells and SARS-CoV-2: An intimate relationship

Lucas Cunha Barbosa et al.

Summary: ACE2 plays a crucial role in regulating the renin-angiotensin-aldosterone system (RAAS) and acts as an entry receptor for SARS-CoV-2 on endothelial cells. The dysfunction of endothelial cells, triggered by factors such as cytokines, hypoxia, and complement activation, may lead to abnormal coagulation and inflammation, contributing to poor prognosis in COVID-19 patients. Endothelial cell-associated therapies, including anticoagulants and immunomodulators, have been proposed to treat COVID-19.

VASCULAR PHARMACOLOGY (2021)

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Article Hematology

IL-18 mediates sickle cell cardiomyopathy and ventricular arrhythmias

Akash Gupta et al.

Summary: IL-18 plays a crucial role in the development of sickle cell disease-related cardiomyopathy, and the main treatment approach is to reduce cardiac fibrosis and VT occurrence by inhibiting IL-18. The level of IL-18 in the blood is related to cardiac function, suggesting IL-18 as a potential therapeutic target for patients with SCD.

BLOOD (2021)

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Article Immunology

Cytokine Signature Induced by SARS-CoV-2 Spike Protein in a Mouse Model

Tingxuan Gu et al.

Summary: This study investigates the mechanism of cytokine storm syndrome (CSS) in COVID-19 and explores potential therapeutic options. TNF-α and IL-6 are suggested to play a role in the occurrence of CSS. The use of certain monoclonal antibodies and inhibitors shows promise in alleviating symptoms of CSS.

FRONTIERS IN IMMUNOLOGY (2021)

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Letter Cardiac & Cardiovascular Systems

SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2

Yuyang Lei et al.

CIRCULATION RESEARCH (2021)

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Article Physiology

The SARS-CoV-2 spike protein subunit S1 induces COVID-19-like acute lung injury in K18-hACE2 transgenic mice and barrier dysfunction in human endothelial cells

Ruben M. L. Colunga Biancatelli et al.

Summary: Research suggests that intratracheal instillation of the S1 subunit of the SARS-CoV-2 spike protein in K18-hACE2 transgenic mice can induce COVID-19-associated lung injury, characterized by weight loss, increased white blood cells and protein concentration, upregulated inflammatory cytokines, histological evidence of lung injury, and activation of specific pathways.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2021)

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Review Peripheral Vascular Disease

COVID-19 is a systemic vascular hemopathy: insight for mechanistic and clinical aspects

David M. Smadja et al.

Summary: COVID-19 caused by SARS-CoV-2 is a systemic disease associated with vascular inflammation and endothelial injury, which can lead to ARDS and hypercoagulation. Besides pro-inflammatory cytokines, endothelial dysfunction can also cause hypercoagulation, thrombosis and pathological angiogenesis.

ANGIOGENESIS (2021)

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Review Respiratory System

At a crossroads: coronavirus disease 2019 recovery and the risk of pulmonary vascular disease

Thomas M. Cascino et al.

Summary: The COVID-19 pandemic has caused nearly 3 million deaths among 139 million infected individuals worldwide. Involvement of the pulmonary vasculature is a major driver of morbidity and mortality. Acute manifestations of pulmonary vascular disease caused by COVID-19 include widespread pulmonary vasculature involvement, myocardial injury, persistent lung disease, and venous thromboembolism. Survivors of COVID-19 may experience ongoing symptoms and be at risk for various types of pulmonary hypertension.

CURRENT OPINION IN PULMONARY MEDICINE (2021)

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Article Cell & Tissue Engineering

SARS-CoV-2 Entry Receptor ACE2 Is Expressed on Very Small CD45-Precursors of Hematopoietic and Endothelial Cells and in Response to Virus Spike Protein Activates the Nlrp3 Inflammasome

Mariusz Z. Ratajczak et al.

Summary: ACE2 is a key player in the RAAS system and serves as the entry receptor for SARS-CoV-2. It is expressed on a specific type of stem cells in human umbilical cord blood, raising concerns about potential virus infection and damage. Interaction of ACE2 with SARS-CoV-2 spike protein activates Nlrp3 inflammasome in stem cells, indicating possible adverse effects on tissue/organ regeneration.

STEM CELL REVIEWS AND REPORTS (2021)

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Review Biochemistry & Molecular Biology

Emerging role of mitophagy in cardiovascular physiology and pathology

Pablo E. Morales et al.

MOLECULAR ASPECTS OF MEDICINE (2020)

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Review Endocrinology & Metabolism

SARS-CoV-2 perturbs the renin-angiotensin system and energy metabolism

Jun Mori et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2020)

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Letter Cardiac & Cardiovascular Systems

The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2

Liang Chen et al.

CARDIOVASCULAR RESEARCH (2020)

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Article Biochemistry & Molecular Biology

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

Alexandra C. Walls et al.

CELL (2020)

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Article Cardiac & Cardiovascular Systems

COVID-19 and Cardiovascular Disease

Kevin J. Clerkin et al.

CIRCULATION (2020)

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Article Cardiac & Cardiovascular Systems

Interleukin-1 and the Inflammasome as Therapeutic Targets in Cardiovascular Disease

Antonio Abbate et al.

CIRCULATION RESEARCH (2020)

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Review Immunology

Targeting potential drivers of COVID-19: Neutrophil extracellular traps

Betsy J. Barnes et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

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Article Medicine, General & Internal

Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China

Chaomin Wu et al.

JAMA INTERNAL MEDICINE (2020)

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Article Medicine, General & Internal

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

Fei Zhou et al.

LANCET (2020)

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Article Cell Biology

NLRP3 Inflammasome and Its Central Role in the Cardiovascular Diseases

Yeqing Tong et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

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Review Physiology

Novel insights on the pulmonary vascular consequences of COVID-19

Francois Potus et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2020)

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Review Cardiac & Cardiovascular Systems

Endothelial dysfunction in COVID-19: a position paper of the ESC Working Group for Atherosclerosis and Vascular Biology, and the ESC Council of Basic Cardiovascular Science

Paul C. Evans et al.

CARDIOVASCULAR RESEARCH (2020)

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Review Biochemistry & Molecular Biology

Inflammasome and Mitophagy Connection in Health and Disease

Jae-Min Yuk et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Immunology

Severe COVID-19: NLRP3 Inflammasome Dysregulated

Daan F. van den Berg et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Medicine, Research & Experimental

Clinical and pathological investigation of patients with severe COVID-19

Shaohua Li et al.

JCI INSIGHT (2020)

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Article Immunology

Serum Cytokine and Chemokine Profile in Relation to the Severity of Coronavirus Disease 2019 in China

Ying Chi et al.

JOURNAL OF INFECTIOUS DISEASES (2020)

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Editorial Material Oncology

Cytokine Storms in Cancer and COVID-19

Casmir Turnquist et al.

CANCER CELL (2020)

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Article Cardiac & Cardiovascular Systems

SARS-CoV-2 infects and induces cytotoxic effacts in human cardiomyocytes

Denisa Bojkova et al.

CARDIOVASCULAR RESEARCH (2020)

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Article Medicine, Research & Experimental

Altered bioenergetics and mitochondrial dysfunction of monocytes in patients with COVID-19 pneumonia

Lara Gibellini et al.

EMBO MOLECULAR MEDICINE (2020)

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Editorial Material Cardiac & Cardiovascular Systems

COVID-19 is, in the end, an endothelial disease

Peter Libby et al.

EUROPEAN HEART JOURNAL (2020)

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Review Cardiac & Cardiovascular Systems

Heart and Lung Multimodality Imagicg in COVID-19

Eustachio Agricola et al.

JACC-CARDIOVASCULAR IMAGING (2020)

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Article Multidisciplinary Sciences

A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures

Kenneth H. Dinnon et al.

NATURE (2020)

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Article Biochemistry & Molecular Biology

An inflammatory cytokine signature predicts COVID-19 severity and survival

Diane Marie Del Valle et al.

NATURE MEDICINE (2020)

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Article Cell Biology

A cross-talk between epithelium and endothelium mediates human alveolar-capillary injury during SARS-CoV-2 infection

Peng Wang et al.

CELL DEATH & DISEASE (2020)

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Review Critical Care Medicine

The vascular endothelium: the cornerstone of organ dysfunction in severe SARS-CoV-2 infection

Stephanie Pons et al.

CRITICAL CARE (2020)

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Article Immunology

Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages

Miriam Merad et al.

NATURE REVIEWS IMMUNOLOGY (2020)

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Letter Biochemistry & Molecular Biology

Adiponectin exacerbates influenza infection in elderly individuals via IL-18

Youzhu Jiang et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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Review Biochemistry & Molecular Biology

Mitochondrial Dysfunction and Aging: Insights from the Analysis of Extracellular Vesicles

Anna Picca et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Biochemistry & Molecular Biology

Inflammasomes, neutrophil extracellular traps, and cholesterol

Alan R. Tall et al.

JOURNAL OF LIPID RESEARCH (2019)

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Review Biochemistry & Molecular Biology

Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

Sarah Pickles et al.

CURRENT BIOLOGY (2018)

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Review Immunology

Age and Age-Related Diseases: Role of inflammation Triggers and Cytokines

Irene Maeve Rea et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Cell Biology

Mechanisms of mitophagy in cellular homeostasis, physiology and pathology

Konstantinos Palikaras et al.

NATURE CELL BIOLOGY (2018)

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Review Cardiac & Cardiovascular Systems

Autophagy and Mitophagy in Cardiovascular Disease

Jose Manuel Bravo-San Pedro et al.

CIRCULATION RESEARCH (2017)

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Review Biochemistry & Molecular Biology

Mechanism and Regulation of NLRP3 Inflammasome Activation

Yuan He et al.

TRENDS IN BIOCHEMICAL SCIENCES (2016)

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Article Urology & Nephrology

Urinary Kidney Injury Molecule 1 (KIM-1) and Interleukin 18 (IL-18) as Risk Markers for Heart Failure in Older Adults: The Health, Aging, and Body Composition (Health ABC) Study

Todd H. Driver et al.

AMERICAN JOURNAL OF KIDNEY DISEASES (2014)

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Article Immunology

Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection

Christopher Lupfer et al.

NATURE IMMUNOLOGY (2013)

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Article Critical Care Medicine

Inflammasome-regulated Cytokines Are Critical Mediators of Acute Lung Injury

Tamas Dolinay et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2012)

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Article Immunology

Inflammatory Monocytes Activate Memory CD8+ T and Innate NK Lymphocytes Independent of Cognate Antigen during Microbial Pathogen Invasion

Saidi M'Homa Soudja et al.

IMMUNITY (2012)

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Article Multidisciplinary Sciences

A role for mitochondria in NLRP3 inflammasome activation

Rongbin Zhou et al.

NATURE (2011)

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Review Biochemistry & Molecular Biology

The Inflammasomes

Kate Schroder et al.

CELL (2010)

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Article Biochemistry & Molecular Biology

IL-18 acts synergistically with IL-15 in stimulating natural killer cell proliferation

Anthony R. French et al.

CYTOKINE (2006)

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Article Virology

An interferon-γ-related cytokine storm in SARS patients

KJ Huang et al.

JOURNAL OF MEDICAL VIROLOGY (2005)

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Article Multidisciplinary Sciences

Inhibition of caspase 1 reduces human myocardial ischemic dysfunction via inhibition of IL-18 and IL-1β

BJ Pomerantz et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

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SARS-CoV-2 spike protein induces IL-18-mediated cardiopulmonary inflammation via reduced mitophagy

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