Correlates of Protection, Thresholds of Protection, and Immunobridging among Persons with SARS-CoV-2 Infection

Several studies have shown that neutralizing antibody levels correlate with immune protection from COVID-19 and have estimated the relationship between neutralizing antibodies and protection. However, results of these stud-ies vary in terms of estimates of the level of neutralizing antibodies required for protection. By normalizing antibody titers, we found that study results converge on a consistent relationship between antibody levels and protection from COVID-19. This finding can be useful for planning future vaccine use, determining population immunity, and reduc-ing the global effects of the COVID-19 pandemic

Automated summary

Multiple studies have demonstrated a correlation between neutralizing antibody levels and protection from COVID-19, estimating the relationship between the two. However, estimates of the required level of neutralizing antibodies for protection vary across these studies. By normalizing antibody titers, it has been found that there is a consistent relationship between antibody levels and protection from COVID-19. This finding is crucial for future vaccine planning, assessing population immunity, and mitigating the global impact of the COVID-19 pandemic.