4.6 Review

Dual therapy for Helicobacter pylori infection

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Article Medicine, General & Internal

The prospective multiple-centre randomized controlled clinical study of high-dose amoxicillin-proton pump inhibitor dual therapy for H. pylori infection in Sichuan areas

Cheng Shen et al.

Summary: This study evaluated the safety and efficacy of high-dose amoxicillin-proton pump inhibitor dual therapy for H. pylori infection, and found that it had similar efficacy to the bismuth-containing quadruple therapy, good compliance, and fewer adverse reactions.

ANNALS OF MEDICINE (2022)

Article Gastroenterology & Hepatology

Rabeprazole plus amoxicillin dual therapy is equally effective to bismuth-containing quadruple therapy for Helicobacter pylori eradication in central China: A single-center, prospective, open-label, randomized-controlled trial

Qiao-Qiao Shao et al.

Summary: This study investigated the efficacy of rabeprazole-amoxicillin or furazolidone regimens as first-line therapy for Helicobacter pylori eradication and factors affecting the eradication rate. The results showed that rabeprazole-amoxicillin dual therapy was equally effective to bismuth-containing quadruple therapy, with fewer side effects. Successful eradication was associated with lower body surface area and non-smoking condition.

HELICOBACTER (2022)

Article Pharmacology & Pharmacy

Comparison of high-dose dual therapy with bismuth-containing quadruple therapy in Helicobacter pylori-infected treatment-naive patients: An open-label, multicenter, randomized controlled trial

Jia-Lun Guan et al.

Summary: In this study, high-dose dual therapy was compared with bismuth-containing quadruple therapy for Helicobacter pylori eradication in treatment-naive patients. The results showed that high-dose dual therapy had similar efficacy and compliance, fewer adverse events, and lower costs compared to quadruple therapy.

PHARMACOTHERAPY (2022)

Article Gastroenterology & Hepatology

Optimization of vonoprazan-amoxicillin dual therapy for eradicating Helicobacter pyloriinfection in China: A prospective, randomized clinical pilot study

Yi Hu et al.

Summary: This study aimed to explore the efficacy of vonoprazan-amoxicillin dual therapy as first-line treatment for Helicobacter pylori infection in China. The study found that neither 7- nor 10-day dual therapy with twice or thrice daily amoxicillin achieved satisfactory efficacy in eradicating H. pylori infection in China.

HELICOBACTER (2022)

Article Medicine, General & Internal

Comparison of Vonoprazan and Amoxicillin Dual Therapy with Standard Triple Therapy with Proton Pump Inhibitor for Helicobacter Pylori eradication: A Randomized Control Trial

Bader Faiyaz Zuberi et al.

Summary: This study compared the efficacy of Vonoprazan based dual treatment and PPI based treatment for eradicating Helicobacter pylori infection. The results showed that patients treated with Vonoprazan based dual treatment had a higher rate of H. pylori negativity post-treatment and experienced fewer adverse events.

PAKISTAN JOURNAL OF MEDICAL SCIENCES (2022)

Review Immunology

Effect of Helicobacter Pylori Eradication on Human Gastric Microbiota: A Systematic Review and Meta-Analysis

Yang Guo et al.

Summary: Successful eradication of H. pylori can reverse dysbiosis of the gastric microbiota and have beneficial effects on the gastric microbiota.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

Article Immunology

Altered Gut Microbiota and Short-Chain Fatty Acids After Vonoprazan-Amoxicillin Dual Therapy for Helicobacter pylori Eradication

Yi Hu et al.

Summary: This study investigated the short-term effect of VA therapy on the gut microbiota and short-chain fatty acids (SCFAs) in H. pylori-infected patients. The results showed that there were changes in the diversity and composition of the gut microbiota before and after treatment, but these changes were restored at the confirmation time point in the high-dose amoxicillin group. VA therapy had minimal impact on the gut microbiota and SCFAs.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

Article Pharmacology & Pharmacy

Comparison of the Dual Therapy of Ilaprazole-Amoxicillin and the Bismuth Quadruple Therapy of Ilaprazole-Amoxicillin-Furazolidone-Bismuth Glycyrrhizinate for Eradication of Helicobacter pylori

Min Niu et al.

Summary: This study compared the safety and efficacy of an amoxicillin/ilaprazole regimen with a bismuth quadruple regimen as the first-line treatment for eradicating H. pylori infection. The results showed that the 14-day IA therapy had similar efficacy to the IAFB quadruple therapy for 10 or 14 days, with better compliance and lower cost for newly treated patients in China.

FRONTIERS IN PHARMACOLOGY (2022)

Article Gastroenterology & Hepatology

Vonoprazan Triple and Dual Therapy for Helicobacter pylori Infection in the United States and Europe: Randomized Clinical Trial

William D. Chey et al.

Summary: This study evaluated the efficacy of vonoprazan, a potassium-competitive acid blocker, in H pylori eradication and found that it was superior to the standard triple therapy, especially in the clarithromycin-resistant strains.

GASTROENTEROLOGY (2022)

Article Gastroenterology & Hepatology

Management of Helicobacter pylori infection: the Maastricht VI/Florence consensus report

Peter Malfertheiner et al.

Summary: Helicobacter pylori infection is recognized as an infectious disease and requires optimized management to prevent complications and gastric cancer. Continuous updates in treatment strategies and testing methods are necessary due to rising antibiotic resistance and the impact on gut microbiota.
Article Gastroenterology & Hepatology

Optimized dual therapy for treatment-naive patients of Helicobacter pylori infection: A large-scale prospective, multicenter, open-label, randomized controlled study

Ying-Ying Han et al.

Summary: This study compared the efficacy, adverse events, and patient compliance of three different high-dose dual regimens in treatment-naive patients of Helicobacter pylori (H. pylori) infection. The results showed that two optimized AMX and PPI dual regimens had similar efficacy, safety, and compliance as compared with the classical dual regimen in H. pylori-infected treatment-naive patients.

HELICOBACTER (2022)

Review Gastroenterology & Hepatology

Amoxicillin-vonoprazan dual therapy for Helicobacter pylori eradication: A systematic review and meta-analysis

Yaobin Ouyang et al.

Summary: This study systematically evaluated the efficacy and safety of amoxicillin-vonoprazan dual therapy for H. pylori infection. The results showed that this therapy had comparable eradication rates to other therapies and a lower rate of side effects.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2022)

Review Microbiology

Primary Antibiotic Resistance of Helicobacter pylori in Different Regions of China: A Systematic Review and Meta-Analysis

Jinnan Chen et al.

Summary: The aim of this study was to observe the primary antibiotic resistance of Helicobacter pylori (H. pylori) in different regions and time periods of China. The results showed that the resistance to clarithromycin and metronidazole was high and increased over time, while resistance to levofloxacin, amoxicillin, tetracycline, and furazolidone remained stable.

PATHOGENS (2022)

Article Medicine, General & Internal

2022 Chinese national clinical practice guideline on Helicobacter pylori eradication treatment

Liya Zhou et al.

Summary: H. pylori infection is a global health burden with high prevalence rates worldwide. This clinical practice guideline provides 12 recommendations for pharmacological treatment of H. pylori eradication, highlighting the efficacy and affordability of bismuth preparations. The recommendations are applicable to resource limited settings with similar antibiotic resistance patterns and sociological challenges.

CHINESE MEDICAL JOURNAL (2022)

Article Medicine, General & Internal

Efficacy and safety of high-dose esomeprazole-amoxicillin dual therapy for Helicobacter pylori rescue treatment: a multicenter, prospective, randomized, controlled trial

Hanxin Bi et al.

Summary: This study compared the efficacy and safety of high-dose PPI-amoxicillin dual therapy and bismuth-containing quadruple therapy for Helicobacter pylori rescue treatment. The results showed that high-dose PPI-amoxicillin dual therapy was non-inferior to bismuth-containing quadruple therapy in terms of eradication rate, with lower incidence of adverse events.

CHINESE MEDICAL JOURNAL (2022)

Article Gastroenterology & Hepatology

Implementation of WeChat-based patient-doctor interaction in the management of Helicobacter pylori infection: A propensity score matching analysis

Bo Shen Lin et al.

Summary: In this study, it was found that the WeChat-based patient-doctor interaction did not lead to better treatment outcomes in H. pylori eradication compared to conventional patient education. Compliance and adverse event rates were also similar between the two groups.

JOURNAL OF DIGESTIVE DISEASES (2022)

Article Gastroenterology & Hepatology

Chinese Consensus Report on Family-Based Helicobacter pylori Infection Control and Management (2021 Edition)

Song-Ze Ding et al.

Summary: Experts discussed and modified 23 original statements on family-based H. pylori infection transmission, control and management, and reached consensus on 16 statements. The final report consists of three parts: H. pylori infection and transmission among family members, prevention and management of H. pylori infection in children and elderly people within households, and strategies for prevention and management of H. pylori infection for family members. In addition to the 'test-and-treat' and 'screen-and-treat' strategies, this consensus also introduced a novel third 'family-based H. pylori infection control and management' strategy to prevent its intrafamilial transmission and development of related diseases.
Review Gastroenterology & Hepatology

The high-dose amoxicillin-proton pump inhibitor dual therapy in eradication ofHelicobacter pyloriinfection

Jianwei Yun et al.

Summary: The high-dose amoxicillin-PPI dual therapy has become a hot topic in improving the eradication rate of H. pylori, with esomeprazole showing superiority among other PPIs. This therapy is considered a promising regimen in clinical practice and further research is needed to explore its efficacy in different populations. Special attention should be given to the impact of CYP2C19 polymorphisms and virulence genotyping on H. pylori eradication.

EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY (2021)

Review Gastroenterology & Hepatology

Use of Pharmacogenomics to Guide Proton Pump Inhibitor Therapy in Clinical Practice

Dana M. Harris et al.

Summary: The article discusses the application of pharmacogenomic information in precision medicine, as well as how to adjust treatment based on published guidelines.

DIGESTIVE DISEASES AND SCIENCES (2021)

Article Gastroenterology & Hepatology

Impact of body size on first-line Helicobacter pylori eradication success using vonoprazan and amoxicillin dual therapy

Hiroyuki Eto et al.

Summary: Through a study of 163 H. pylori patients, successful eradication of H. pylori with VA-dual therapy was found to be associated with the small body size of patients, while the incidence of adverse events was higher in women.

HELICOBACTER (2021)

Article Gastroenterology & Hepatology

Impact of Helicobacter pylori eradication on the gastric microbiome

Li-Qi Mao et al.

Summary: This study investigated the impact of Helicobacter pylori eradication on the gastric microflora, revealing that successful eradication leads to partial recovery of the stomach microbiota. However, this restoration is incomplete and may pose long-term risks.

GUT PATHOGENS (2021)

Review Gastroenterology & Hepatology

PPI-amoxicillin dual therapy four times daily is superior to guidelines recommended regimens in the Helicobacter pylori eradication therapy within Asia: A systematic review and meta-analysis

Cailing Li et al.

Summary: PPI-amoxicillin dual therapy administered four-times daily has shown better efficacy and safety in H. pylori eradication compared to other regimens, especially in first-line therapy and primarily in Asia.

HELICOBACTER (2021)

Article Gastroenterology & Hepatology

The impact of Helicobacter pylori infection, eradication therapy, and probiotics intervention on gastric microbiota in young adults

Ziying Yuan et al.

Summary: This study investigated the impact of H. pylori eradication and probiotics intervention on the gastric microbiota in young adults. The results showed changes in the diversity and composition of gastric microbiota after successful H. pylori eradication, with probiotics supplementation partially aiding in restoring dysbiosis. However, probiotics alone may not be necessary for H. pylori-infected young adults.

HELICOBACTER (2021)

Article Gastroenterology & Hepatology

10-Day and 14-day high-dose dual therapy for the treatment of Helicobacter pylori: A propensity score matching analysis

Pei-Ying Zou et al.

Summary: This retrospective study compared the efficacy and safety of high-dose dual therapy (HDDT) for 10 days vs 14 days, finding that the 14-day regimen had a higher eradication rate for Helicobacter pylori than the 10-day regimen.

HELICOBACTER (2021)

Article Gastroenterology & Hepatology

Lower impact of vonoprazan-amoxicillin dual therapy on gut microbiota for Helicobacter pylori eradication

Toshiki Horii et al.

Summary: Both VA dual therapy and VAC triple therapy can eradicate H. pylori and alter the gut microbiota, but VA dual therapy has minimal impact on gut microbiota diversity and relative abundance compared to VAC triple therapy.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2021)

Review Medicine, General & Internal

Recent progress in Helicobacter pylori treatment

Yi Hu et al.

CHINESE MEDICAL JOURNAL (2020)

Article Gastroenterology & Hepatology

Efficacy of modified esomeprazole-amoxicillin dual therapies for Helicobacter pylori infection: an open-label, randomized trial

Yi Zhang et al.

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY (2020)

Review Infectious Diseases

The Puzzle of Coccoid Forms ofHelicobacter pylori: Beyond Basic Science

Enzo Ierardi et al.

ANTIBIOTICS-BASEL (2020)

Review Gastroenterology & Hepatology

High dose PPI-amoxicillin dual therapy for the treatment ofHelicobacter pyloriinfection: a systematic review with meta-analysis

Yang-Jie Zhu et al.

THERAPEUTIC ADVANCES IN GASTROENTEROLOGY (2020)

Review Medicine, General & Internal

Evaluation and Management of Penicillin Allergy A Review

Erica S. Shenoy et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2019)

Article Microbiology

The Human Gastric Microbiome Is Predicated upon Infection with Helicobacter pylori

Ingeborg Klymiuk et al.

FRONTIERS IN MICROBIOLOGY (2017)

Article Gastroenterology & Hepatology

Optimized high-dose amoxicillinuproton-pump inhibitor dual therapies fail to achieve high cure rates in China

Jia-Li Hu et al.

SAUDI JOURNAL OF GASTROENTEROLOGY (2017)

Article Gastroenterology & Hepatology

High-dose Dual Therapy Is Superior to Standard First-line or Rescue Therapy for Helicobacter pylori Infection

Jyh-Chin Yang et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2015)

Article Pharmacology & Pharmacy

Effectiveness of three times daily lansoprazole/amoxicillin dual therapy for Helicobacter pylori infection in Korea

Seung Young Kim et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2012)

Article Gastroenterology & Hepatology

Dual therapy for third-lineHelicobacter pylorieradication and urea breath test prediction

Toshihiro Nishizawa

WORLD JOURNAL OF GASTROENTEROLOGY (2012)

Article Multidisciplinary Sciences

Molecular analysis of the bacterial microbiota in the human stomach

EM Bik et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)