期刊
CLINICAL AND EXPERIMENTAL MEDICINE
卷 -, 期 -, 页码 -出版社
SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s10238-023-01040-1
关键词
Celiac disease; Selective IgA deficiency; Tissue transglutaminase; Anti-endomysium antibodies; Follow-up; Children
This study aims to analyze the decreasing dynamics of IgG anti-tTG in CD patients who start a GFD. The results show that the normalization rates of IgG anti-tTG are slower for SIgAD CD patients compared to IgA competent CD patients, while IgA anti-tTG reaches lower values in a higher proportion of IgA competent patients.
Studies are scarce regarding IgG anti-tissue transglutaminase 2 (tTG) normalization in selective IgA deficient (SIgAD) celiac disease (CD) patients after beginning a gluten free diet (GFD). The aim of this study is to analyse the decreasing dynamics of IgG anti-tTG in patients diagnosed with CD who start a GFD. To achieve this objective, IgG and IgA anti-tTG levels at diagnosis and during follow-up in 11 SIgAD CD patients and in 20 IgA competent CD patients were retrospectively evaluated. At diagnosis, statistical differences were not found when comparing IgA anti-tTG levels of IgA competent subjects with IgG anti-tTG levels of SIgAD subjects. Regarding the decreasing dynamics, even though no statistical differences were found (p = 0.06), normalization rates were slower for SIgAD CD patients. After 1 and 2 years on GFD, respectively, only 18.2% and 36.3% of the SIgAD CD patients normalized IgG anti-tTG levels; otherwise, IgA anti-tTG reached values under the reference values in 30% and 80% of the IgA competent patients in the same time-points. Although IgG anti-tTG has demonstrated a high diagnostic efficiency in SIgAD CD pediatric patients, this test does not appear to be as precise for long-term GFD response monitoring as IgA anti-tTG levels in IgA sufficient patients.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据