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卷 25, 期 9, 页码 1578-1582出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.3c004711578Org
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In this study, a nickel-catalyzed diastereoselective cross-electrophile ring opening reaction of 7-oxabenzonorbornadienes with aromatic aldehydes was developed, using Zn as the stoichiometric reductant. This reaction achieved stereoselective bond formation between two disubstituted sp(3)-hybridized carbon centers, providing a variety of 1,2-dihydronaphthalenes with full diastereocontrol of three consecutive stereogenic centers.
In this protocol, we developed a nickel-catalyzed diastereoselective cross-electrophile ring opening reaction of 7-oxabenzonorbornadienes with aromatic aldehydes as the electro-philic coupling partner utilizing Zn as the stoichiometric reductant. In this reaction, a challenging stereoselective bond formation between two disubstituted sp(3)-hybridized carbon centers has been achieved, furnishing a variety of 1,2-dihydronaphthalenes with full diastereocontrol of three consecutive stereogenic centers.
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