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2023 Alzheimer's disease facts and figures

ALZHEIMERS & DEMENTIA (2023)

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Summary: This study synthesized literature on the prevalence of Alzheimer's disease (AD) at different stages and estimated the global number of individuals in the early stages of AD. The findings revealed that there are approximately 320 million individuals with AD dementia, 690 million with prodromal AD, and 315 million with preclinical AD globally. Together, these individuals constitute 22% of the population aged 50 and above. However, uncertainties remain in these estimates, particularly in low- and middle-income regions where biomarker studies are lacking.

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Is Dementia-Specific Caregiving Compared With Non-Dementia Caregiving Associated With Physical Difficulty Among Caregivers for Community-Dwelling Adults?

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Are dementia services and support organisations meeting the needs of Lesbian, Gay, Bisexual and Transgender (LGBT) caregivers of LGBT people living with dementia? A scoping review of the literature

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ALZHEIMERS & DEMENTIA (2022)

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Unmet needs and health-related quality of life of dementia family caregivers transitioning from home to long-term care: A scoping review

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The Impact of the COVID-19 Pandemic on Mental Health, Occupational Functioning, and Professional Retention Among Health Care Workers and First Responders

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Fawn A. Cothran et al.

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Caregiving Burden Among Caregivers of People With Dementia Through the Lens of Intersectionality

Ruotong Liu et al.

Summary: This article examines the differences in caregiving burdens across the intersectionality of race and gender. The study finds that Black male caregivers are more likely to face financial burden, while White female caregivers are more likely to face emotional burden. Effective interventions and programs for dementia caregivers should pay special attention to the types of burdens experienced by different population subgroups.

GERONTOLOGIST (2022)

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DEMENTIA-INTERNATIONAL JOURNAL OF SOCIAL RESEARCH AND PRACTICE (2022)

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Laura T. Pizzi et al.

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INNOVATION IN AGING (2022)

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Consideration of sex and gender in Alzheimer's disease and related disorders from a global perspective

Michelle M. Mielke et al.

Summary: Sex or gender differences in the risk of Alzheimer's disease and related dementias differ by world region, and there are potentially modifiable risk factors for intervention. The study emphasizes the importance of considering gender, biologic sex, and sexual orientation in understanding the risk, prevention, and diagnosis of ADRD. Identifying the drivers of sex and gender differences in ADRD can help develop interventions to reduce inequities and global ADRD risk.

ALZHEIMERS & DEMENTIA (2022)

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Ekin Secinti et al.

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AMERICAN JOURNAL OF PREVENTIVE MEDICINE (2022)

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Prevalence of Azheimer's and Related Dementia Diseases and Risk Factors Among Transgender Adults, Florida, 2012-2020

Yi Guo et al.

Summary: The prevalence of Alzheimer's disease and related dementias is significantly higher in transgender adults compared to cisgender adults, with more risk factors present in the transgender population. This underscores the need for further research on dementia risks in transgender and other gender minority populations.

AMERICAN JOURNAL OF PUBLIC HEALTH (2022)

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Association of Race and Ethnicity With Incidence of Dementia Among Older Adults

Erica Kornblith et al.

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JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2022)

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The Experience of Alzheimer's Disease Family Caregivers in a Latino Community: Expectations and Incongruences in Support Services

Iveris L. Martinez et al.

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Editorial Material Geriatrics & Gerontology

Recommendations for Advancing Research With Sexual and Gender Minority Older Adults

Jason D. Flatt et al.

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Article Geriatrics & Gerontology

Stressors and Acceptability of Services Among Black Caregivers of Persons With Memory Problems

Deborah Ejem et al.

Summary: The purpose of this study was to identify the stressors, services of interest, and barriers to use of services for Black family caregivers of persons with memory problems. The study found that the most common stressors for Black family caregivers were the memory problems patients, managing their financial affairs, and managing their comorbid conditions. The caregivers were most interested in educational material on treatment and diagnosis, caring for people with dementia, understanding dementia, and financial/legal services. Barriers to use of services included transportation difficulties and the need for a relief person. The results suggest that interventions that include virtual conferencing modalities may be more effective for Black family caregivers.

JOURNAL OF GERONTOLOGICAL NURSING (2022)

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Review Geriatrics & Gerontology

Hospice interventions for persons living with dementia, family members and clinicians: A systematic review

Rebecca K. F. Lassell et al.

Summary: This study conducted a systematic review of hospice interventions for persons with dementia, highlighting the scarce and early-stage research in this area. More research with rigorous designs, diverse samples, and outcomes considering the concordance of care is needed to improve care coordination.

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2022)

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Dissemination of a successful dementia care program: Lessons from early adopters

Kristin Lees Haggerty et al.

Summary: This qualitative study examines the barriers and facilitators to implementing the Alzheimer's and Dementia Care Program (ADC Program) among early adopting sites in the United States. The study finds that engagement from site leaders, the multifaceted nature of the dementia care specialist role, and technical assistance from qualified experts are crucial for the success of the program. However, appropriate payment and support mechanisms are needed for the comprehensive dementia care to continue.

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Emergency and post-emergency care of older adults with Alzheimer's disease/Alzheimer's disease related dementias

Jacob D. Hill et al.

Summary: Patients with dementia have a high short-term mortality rate when visiting the emergency department. Despite this, acute care, ED revisits, and inpatient stays remain the predominant modes of care delivery.

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2022)

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Article Geriatrics & Gerontology

Caring for a Relative With Dementia in Long-Term Care During COVID-19

Lauren L. Mitchell et al.

Summary: The COVID-19 pandemic posed unique challenges for caregivers of persons with dementia in long-term care facilities. This qualitative study aimed to identify the challenges associated with caring for a relative with dementia during the pandemic and highlight the resources and strategies that caregivers found helpful. The study collected open-ended survey responses and conducted interviews, and thematic analysis was used to analyze the data.

JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION (2022)

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Article Genetics & Heredity

New insights into the genetic etiology of Alzheimer's disease and related dementias

Celine Bellenguez et al.

Summary: By characterizing the genetic landscape of Alzheimer's disease and related dementias, new loci have been identified and a new genetic risk score associated with the risk of future Alzheimer's disease and dementia has been generated.

NATURE GENETICS (2022)

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Genetic Risk, Midlife Life's Simple 7, and Incident Dementia in the Atherosclerosis Risk in Communities Study

Adrienne Tin et al.

Summary: This study investigated the association between Life's Simple 7 (LS7) scores and dementia risk among individuals with high genetic risk. It found that higher LS7 scores were consistently associated with lower risk of dementia across different levels of genetic risk. However, larger sample sizes from diverse populations are needed to obtain more reliable estimates of the effects of modifiable health factors on dementia risk.

NEUROLOGY (2022)

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Article Multidisciplinary Sciences

Minority salience and the overestimation of individuals from minority groups in perception and memory

Rasha Kardosh et al.

Summary: Our cognitive system is inclined to pay more attention to uncommon and unexpected things. Individuals from minority groups are inherently uncommon and often unexpected, making them psychologically salient in perception, memory, and visual awareness. This salience leads to an overestimation of the prevalence of minorities, resulting in a misguided view of our social environments – an illusion of diversity. This overestimation decreases support for diversity-promoting policies.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

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Review Medicine, General & Internal

Experiences of older immigrants living with dementia and their carers: a systematic review and meta-synthesis

Pelden Chejor et al.

Summary: This study provides a systematic review and meta-synthesis of the experiences of older immigrants living with dementia and their carers. The results reveal that older immigrants living with dementia and their families face multiple challenges in terms of caregiving. However, there appears to be little difference in experiences between those who have migrated to a new country and those who were born and aged in the same country, but there are differences in their ability to access available services.

BMJ OPEN (2022)

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Article Clinical Neurology

Risk Factors Associated With Alzheimer Disease and Related Dementias by Sex and Race and Ethnicity in the US

Roch A. Nianogo et al.

Summary: This study updates the estimates of the proportion of ADRDs in the US that are associated with modifiable risk factors and examines the differences by sex and race and ethnicity. The findings suggest that the risk factors associated with ADRDs have changed over the past decade and differ based on sex and race and ethnicity.

JAMA NEUROLOGY (2022)

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Article Clinical Neurology

Trends in Mortality Rates Among Medicare Enrollees With Alzheimer Disease and Related Dementias Before and During the Early Phase of the COVID-19 Pandemic

Lauren Gilstrap et al.

Summary: This study examines the association between COVID-19 infection rates and excess mortality among individuals with Alzheimer's disease and related dementias (ADRD). The results indicate that there is an increased risk of excess mortality among older adults with ADRD, especially for Asian, Black, and Hispanic populations and those living in nursing homes, even in areas with low COVID-19 prevalence.

JAMA NEUROLOGY (2022)

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Article Multidisciplinary Sciences

Human brain anatomy reflects separable genetic and environmental components of socioeconomic status

Hyeokmoon Kweon et al.

Summary: This study reveals the relationship between socioeconomic status (SES) and brain structure, showing the significant roles of genetic and environmental factors in influencing this relationship. Specifically, certain brain regions are more influenced by genetic factors in SES differences, while other regions are more influenced by environmental factors.

SCIENCE ADVANCES (2022)

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Article Gerontology

Transcending inequities in dementia care in Black communities: Lessons from the maximizing independence at home care coordination program

Danetta H. Sloan et al.

Summary: This study examines the impact and perception of the Maximizing Independence at Home (MIND) intervention on care partners in the Black community. The findings indicate unique needs and challenges within the Black community when it comes to caring for individuals with dementia. The MIND program is perceived to be beneficial in helping care partners access resources, providing socialization opportunities, conducting comprehensive assessments, and giving much-needed breaks. Recommendations include increasing diversity among MIND program personnel, improving program promotion, and enhancing communication.

DEMENTIA-INTERNATIONAL JOURNAL OF SOCIAL RESEARCH AND PRACTICE (2022)

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Article Gerontology

A Comparative Analysis of Family Quality of Life Between Heterosexual and Sexual Minority Caregivers of People with Dementia

Joel G. Anderson et al.

Summary: This study used psychosocial measures to describe the characteristics and family quality of life of caregivers for people with Alzheimer's disease or related dementias. The study found that sexual minority caregivers had different characteristics and higher family quality of life scores compared to heterosexual caregivers.

JOURNAL OF APPLIED GERONTOLOGY (2022)

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Article Gerontology

Exploring Coping Strategies and Barriers in Dementia Care: A Mixed-Methods Study of African American Family Caregivers in Kentucky

Sunshine M. Rote et al.

Summary: This study examines coping strategies and barriers faced by African American dementia caregivers in Kentucky. Love-based coping, religion-based coping, and family support are identified as the three main strategies. Survey results show that over 90% of participants provide care for family members and for religious reasons. However, focus group data reveals that caregivers also struggle with time constraints, lack of support, and the high cost of formal care.

JOURNAL OF APPLIED GERONTOLOGY (2022)

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Article Multidisciplinary Sciences

Trends in inequalities in the prevalence of dementia in the United States

Peter Hudomiet et al.

Summary: This paper presents estimates of dementia prevalence among older adults in the United States from 2000 to 2016. The study found a significant decline in age-adjusted dementia prevalence, with females being more likely to live with dementia, although the sex difference has narrowed. Inequalities in education, earnings, and racial and ethnic groups have also decreased. The study also observed a substantial increase in education level, which explains a portion of the reduction in dementia prevalence.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

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Article Family Studies

A Different Way to Survive: The Experiences of Family Caregivers of Persons Living With Dementia During the COVID-19 Pandemic

Sara Masoud et al.

Summary: The COVID-19 pandemic has had a significant impact on the health and quality of life of family caregivers of persons living with dementia, particularly in terms of increased caregiving responsibilities.

JOURNAL OF FAMILY NURSING (2022)

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Article Family Studies

Experiences of Black American Dementia Caregivers During the COVID-19 Pandemic

Sloan Oliver et al.

Summary: This qualitative study explores the experience of Black dementia caregivers during the COVID-19 pandemic in the United States. The results indicate that the experience of Black dementia caregivers overlaps with existing literature on the experiences of dementia caregivers of other races during COVID-19. These results can assist in addressing the specific needs and improving the experiences of dementia caregivers in current and future public health crises.

JOURNAL OF FAMILY NURSING (2022)

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Review Geriatrics & Gerontology

Nonpharmacological Interventions for Management of Behavioral and Psychological Symptoms of Dementia in Long-Term Care Facilities by Direct Caregivers: A Systematic Review

Theresa Lynn Lyons et al.

Summary: Behavioral and psychological symptoms of dementia pose significant challenges for both patients and direct caregivers. Nonpharmacological interventions have shown to be effective in managing these symptoms, but proper training is necessary for direct caregivers to utilize them effectively.

JOURNAL OF GERONTOLOGICAL NURSING (2022)

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Review Nursing

Effects of telehealth intervention for people with dementia and their carers: A systematic review and meta-analysis of randomized controlled studies

Ita Daryanti Saragih et al.

Summary: This study systematically examined the impact and effectiveness of telehealth-delivered psychoeducational and behavioral interventions among persons with dementia and their caregivers. The findings suggest that telehealth interventions can reduce depression among persons diagnosed with dementia while improving caregivers' perceived competency. However, no statistically significant effects were observed on cognitive function or various aspects of quality of life for the subjects.

JOURNAL OF NURSING SCHOLARSHIP (2022)

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Article Geriatrics & Gerontology

Dissemination of a successful dementia care program: Lessons to facilitate spread of innovations

David B. Reuben et al.

Summary: Despite the challenges in disseminating dementia care programs, successful innovations can be implemented in diverse health systems with the help of local champions and technical support.

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2022)

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Review Clinical Neurology

Applying the Bradford Hill Criteria for Causation to Repetitive Head Impacts and Chronic Traumatic Encephalopathy

Christopher J. Nowinski et al.

Summary: Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repetitive head impacts (RHI). While it was initially linked to boxing, recent studies have found CTE in other sports as well, leading to debates over the causal relationship between RHI and CTE. By evaluating medical literature, convincing evidence of a causal relationship between RHI and CTE has been found.

FRONTIERS IN NEUROLOGY (2022)

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Review Psychiatry

Dementia and Mental Health During the COVID-19 Pandemic: A Systematic Review

Julia Mariano Gaigher et al.

Summary: This systematic review compares and discusses the impact of the COVID-19 pandemic on the mental health of people with dementia and their caregivers, in comparison to other populations. The findings suggest that social isolation can exacerbate neuropsychiatric symptoms and motor difficulties in individuals with dementia, while increasing caregiver burden and anxiety.

FRONTIERS IN PSYCHIATRY (2022)

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Review Gerontology

Do Caregiver Interventions Improve Outcomes in Relatives With Dementia and Mild Cognitive Impairment? A Comprehensive Systematic Review and Meta-Analysis

Sheung-Tak Cheng et al.

Summary: Nonpharmacological interventions for informal caregivers of people with dementia and mild cognitive impairment have benefits for both caregivers and care-recipients. These interventions can improve caregiving capability, reduce burden and depression among caregivers, decrease negative mood contagion, and also reduce neuropsychiatric symptoms, enhance cognition and quality of life, and delay institutionalization and mortality in care-recipients. Different types of interventions have different effects, with care coordination/case management, psychoeducation-b, and CR training being the more potent interventions. The development of guidelines and family-centered programs with flexibility in delivery are discussed as future directions.

PSYCHOLOGY AND AGING (2022)

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Article Medicine, General & Internal

Changes in Burnout and Satisfaction With Work-Life Integration in Physicians During the First 2 Years of the COVID-19 Pandemic

Tait D. Shanafelt et al.

MAYO CLINIC PROCEEDINGS (2022)

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Article Clinical Neurology

Estimating the Prevalence of Dementia and Mild Cognitive Impairment in the US The 2016 Health and Retirement Study Harmonized Cognitive Assessment Protocol Project

Jennifer J. Manly et al.

Summary: This study provides national estimates of dementia and MCI prevalence in the US in 2016 using a comprehensive neuropsychological test battery and a large sample, revealing a higher burden of dementia and MCI among older Black and Hispanic adults, as well as those with lower education levels.

JAMA NEUROLOGY (2022)

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Article Clinical Neurology

The adverse effect of modifiable dementia risk factors on cognition amplifies across the adult lifespan

Annalise A. LaPlume et al.

Summary: The prevalence of modifiable risk factors for dementia increases with age, and each additional risk factor is associated with a decline in cognitive performance equivalent to accelerated aging. Individuals in their forties to seventies without any risk factors show similar cognitive performance to individuals 10 or 20 years younger with multiple risk factors.

ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING (2022)

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Article Clinical Neurology

Dementia diagnosis and utilization patterns in a racially diverse population within an integrated health care delivery system

Huong Q. Nguyen et al.

Summary: This study examines the detection, care, and outcomes of Alzheimer's disease and related dementias (ADRD) within a large healthcare system. The results show that ADRD is under-diagnosed and diagnosed at later stages, resulting in higher healthcare utilization and mortality. Dementia specialists function primarily as consultants and do not significantly mitigate acute care use. Improving ADRD care could involve proactive detection, care planning, and the role of specialists.

ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS (2022)

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Article Health Care Sciences & Services

Trends in US Medicare Decedents' Diagnosis of Dementia From 2004 to 2017

Matthew A. Davis et al.

Summary: This cross-sectional study examines the trends in diagnosis frequency of Alzheimer disease and related dementias (ADRD) within the last 2 years of life, along with changes in billing practices, characteristics of the diagnosed population, and intensity of end-of-life care. The study finds a substantial increase in ADRD diagnosis among older adult decedents, indicating a growing awareness and temporal changes in billing. The intensity of end-of-life care, however, declined on most measures.

JAMA HEALTH FORUM (2022)

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Article Clinical Neurology

Home health utilization association with discharge to community for people with dementia

Sara Knox et al.

Summary: This study aimed to identify home health utilization factors associated with successful discharge to community for patients with and without Alzheimer's disease and related dementias (ADRD) after home health care. The results showed that physical therapy services, longer episodes of care, and more than 10 visits increased the likelihood of successful discharge to community, while speech therapy, nursing, home health aide visits, and early discharge decreased the likelihood. Understanding these factors is important for improving home health outcomes for ADRD patients.

ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS (2022)

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Article Geriatrics & Gerontology

Suicide risk in caregivers of people with dementia: a systematic review and meta-analysis

Luisa Solimando et al.

Summary: This study aimed to assess the prevalence of suicidal ideation, suicidal attempts, and suicide rates among caregivers of patients with dementia. The study found a high prevalence of suicidal ideation among caregivers, with significant variation in rates across different studies. Some studies also reported the prevalence of suicidal attempts and suicide.

AGING CLINICAL AND EXPERIMENTAL RESEARCH (2022)

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Article Geriatrics & Gerontology

The Use of Technology Among Persons With Memory Concerns and Their Caregivers in the United States During the COVID-19 Pandemic: Qualitative Study

Elizabeth A. Albers et al.

Summary: The study aims to understand why and how some individuals with memory concerns and their caregivers altered their use of technology during the COVID-19 pandemic, and found that technology plays a significant role in providing independence and relieving caregiving burden.

JMIR AGING (2022)

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Review Clinical Neurology

Alzheimer's disease drug development pipeline: 2022

Jeffrey Cummings et al.

Summary: Alzheimer's disease is a global health crisis, and there are numerous clinical trials and drugs in development to treat and improve the symptoms and progression of the disease. The pipeline of drug development includes a diverse array of treatments, including disease-modifying therapies, cognitive enhancing treatments, and drugs for neuropsychiatric symptoms. Advances in drug design, outcome measures, biomarker use, and trial conduct show promise in accelerating the delivery of new and improved treatments for Alzheimer's disease patients.

ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS (2022)

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Article Clinical Neurology

The adverse effect of modifiable dementia risk factors on cognition amplifies across the adult lifespan

Annalise A. LaPlume et al.

Summary: The study found that older adults have more modifiable dementia risk factors than middle-aged and younger adults, and each additional risk factor is associated with lower cognitive performance. People with no risk factors in their forties to seventies exhibited similar cognitive performance to people 10 or 20 years younger with many risk factors.

ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING (2022)

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Review Geriatrics & Gerontology

Online support for family caregivers of people with dementia: a systematic review and meta-analysis of RCTs and quasi-experimental studies

Igone Etxeberria et al.

Summary: This study found that online support interventions targeted at family caregivers can help improve their psychological wellbeing, particularly in reducing the impact of depression, anxiety, burden, and caregiving competence. However, more rigorous randomized controlled trials are needed to further evaluate the effectiveness of these interventions.

AGING & MENTAL HEALTH (2021)

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Article Health Care Sciences & Services

Advance Care Planning for African American Caregivers of Relatives With Dementias: Cluster Randomized Controlled Trial

Gloria J. Bonner et al.

Summary: The study evaluated the efficacy of the ACT-Plan intervention for African-American family caregivers on end-of-life decision making for relatives with dementias. Results showed that the intervention significantly increased knowledge and self-efficacy related to end-of-life treatments, as well as knowledge of dementia. Despite similar intentions to make end-of-life treatment decisions between treatment arms, the findings suggest promise for enhancing informed decision making in this population.

AMERICAN JOURNAL OF HOSPICE & PALLIATIVE MEDICINE (2021)

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Article Geriatrics & Gerontology

I've been always strong to conquer any suffering: challenges and resilience of Chinese American dementia caregivers in a life course perspective

Jinyu Liu et al.

Summary: This study explored the resilience and challenges faced by Chinese American dementia caregivers, highlighting physical and emotional exhaustion as the most frequently mentioned challenge. The study also emphasized the importance of culturally meaningful services for immigrant caregivers to improve their resilience in addressing complex challenges.

AGING & MENTAL HEALTH (2021)

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Review Geriatrics & Gerontology

Implementing post diagnostic dementia care in primary care: a mixed-methods systematic review

Rachael Frost et al.

Summary: The study found that primary care-led dementia care models are feasible and well-received. Key intervention components include information provision, social and emotional support, and links to community organizations. Factors influencing feasibility include provider engagement and leadership, dementia care capacity, resources, and collaboration.

AGING & MENTAL HEALTH (2021)

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Editorial Material Geriatrics & Gerontology

Are Medical Care Expenses Higher for Spouses Who Provide Dementia Care?`

Steven M. Albert

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY (2021)

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Article Geriatrics & Gerontology

Incremental Health Care Expenditures of the Spouses of Older Adults With Alzheimer's Diseases and Related Dementias (ADRD)

Jun Chu et al.

Summary: The study found that having a spouse with ADRD is associated with higher healthcare expenditures in older adults, mainly due to the higher rate of comorbidities, functional limitations, and older age in this group. Therefore, the importance of tailoring preventative healthcare and social services to meet the needs of this group has been emphasized.

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY (2021)

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Article Geriatrics & Gerontology

A New Look at Cohort Trend and Underlying Mechanisms in Cognitive Functioning

Hui Zheng

Summary: The study found that cognitive functioning has been improving from the Greatest Generation to Late Children of Depression and War Babies, but then significantly declines from the Early-Baby Boomers onwards. This pattern is universally observed across genders, race/ethnicities, education groups, occupations, income, and wealth quartiles.

JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES (2021)

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Review Medicine, General & Internal

Establishing the effectiveness of technology-enabled dementia education for health and social care practitioners: a systematic review

Kevin Muirhead et al.

Summary: This study evaluated contemporary experimental evidence on technology-enabled dementia education for health and social care practitioners, finding that most interventions had significant effects on knowledge and skills. Online education and computer-based approaches were commonly used, with case-based instruction and videos being common instructional strategies.

SYSTEMATIC REVIEWS (2021)

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Article Gerontology

Characteristics of Sexual and Gender Minority Caregivers of People With Dementia

Joel G. Anderson et al.

Summary: This study used online survey and social media recruitment to describe the psychosocial measures of sexual and gender minority caregivers of individuals with ADRD. The research highlighted the challenges these caregivers face in terms of family quality of life and depressive symptoms, and emphasized the importance of developing targeted interventions for this population.

JOURNAL OF AGING AND HEALTH (2021)

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Article Geriatrics & Gerontology

Do Caregiving Factors Affect Hospitalization Risk Among Disabled Older Adults?

Halima Amjad et al.

Summary: Although older adults with dementia have similar hospitalization rates compared to those without, caregiving factors have a similar impact on hospitalization risk for both groups.

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2021)

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Article Public, Environmental & Occupational Health

One call makes a difference: An evaluation of the Alzheimer's Association National Helpline on dementia caregiver outcomes

Nancy A. Hodgson et al.

Summary: The study evaluated the effects of care consultation delivered through the Alzheimer's Association National Helpline and found that callers reported significant improvements in caregiver mental health scores and ability to manage emotions within one week. While no differences were found between the two conditions, receiving a single call from the helpline proved beneficial for caregivers.

PATIENT EDUCATION AND COUNSELING (2021)

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Article Cell Biology

Healthy memory aging - the benefits of regular daily activities increase with age

Olga Krakovska et al.

Aging-US (2021)

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Article Clinical Neurology

The chronic neuropsychiatric sequelae of COVID-19: The need for a prospective study of viral impact on brain functioning

Gabriel A. de Erausquin et al.

Summary: The impact of SARS-CoV-2 on the central nervous system has raised concerns about the risk of later life cognitive decline, Alzheimer's disease, and other dementia. An international consortium has been formed to study the short and long-term consequences of the virus on the CNS and enroll individuals for evaluations to better understand the underlying biology contributing to AD and dementia.

ALZHEIMERS & DEMENTIA (2021)

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Review Medicine, General & Internal

Practical recommendations for timely, accurate diagnosis of symptomatic Alzheimer's disease (MCI and dementia) in primary care: a review and synthesis

J. L. Liss et al.

Summary: Timely diagnosis and collaboration between primary care clinicians and specialists are crucial in adapting to new treatment paradigms and disease-modifying therapies in Alzheimer's disease care.

JOURNAL OF INTERNAL MEDICINE (2021)

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Article Geriatrics & Gerontology

Front-line Nursing Home Staff Experiences During the COVID-19 Pandemic

Elizabeth M. White et al.

Summary: During the COVID-19 pandemic, nursing home staff faced ongoing constraints on testing and continued reliance on crisis standards for extended use of personal protective equipment. They expressed fears of infection, empathy for residents, burnout due to increased workloads, staffing shortages, and emotional burden, as well as the demoralizing impact of negative media coverage and lack of organizational communication and teamwork. These challenges are likely to contribute to increased burnout, turnover, and staff shortages in the long term for this already strained and vulnerable workforce.

JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION (2021)

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Article Geriatrics & Gerontology

Same-Sex Couples and Cognitive Impairment: Evidence From the Health and Retirement Study

Hui Liu et al.

Summary: The study found that the odds of cognitive impairment were 78% higher for same-sex partners compared to different-sex partners. This disparity was mainly attributed to differences in marital status, and to a lesser extent, differences in physical and mental health.

JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES (2021)

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Article Health Care Sciences & Services

Measuring Primary Care Exam Length Using Electronic Health Record Data

Hannah T. Neprash et al.

Summary: This study utilized electronic health records data to measure primary care physician-patient visit length, finding that the average primary care exam was 18.0 minutes long and typically ran 1.2 minutes later than scheduled. Scheduled visits for 10 or 15 minutes were more likely to exceed their allotted time compared to visits scheduled for 20 or 30 minutes.

MEDICAL CARE (2021)

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Editorial Material Clinical Neurology

The effects of the COVID-19 pandemic on people with dementia

Katya Numbers et al.

Summary: People with dementia are at high risk of SARS-CoV-2 infection due to cognitive symptoms and living arrangements in care homes. Once infected, they are more likely to experience severe outcomes and death. Certain genotype may increase the risk of COVID-19 hospitalization, and dementia in older adults, especially those in care homes, can lead to worsening psychiatric symptoms and severe behavioral disturbances during the pandemic.

NATURE REVIEWS NEUROLOGY (2021)

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Editorial Material Medicine, General & Internal

How Structural Racism Works - Racist Policies as a Root Cause of US Racial Health Inequities

Zinzi D. Bailey et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Environmental Sciences

Neighborhood Characteristics and the Mental Health of Caregivers Cohabiting with Care Recipients Diagnosed with Alzheimer's Disease

Dana M. Alhasan et al.

Summary: This study found that caregivers living in low or medium income neighborhoods experienced higher psychological distress, suggesting that neighborhood characteristics may amplify other social stressors experienced by caregivers.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

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Article Clinical Neurology

Trends in Relative Incidence and Prevalence of Dementia Across Non-Hispanic Black and White Individuals in the United States, 2000-2016

Melinda C. Power et al.

Summary: This study analyzed data from the Health and Retirement Study to examine the changes in racial disparities in Alzheimer's dementia prevalence and incidence among non-Hispanic Black and White individuals in the US from 2000 to 2016. The results indicated that there was no significant change in racial disparities in dementia risk during the study period. Further efforts are needed to address and reduce these disparities.

JAMA NEUROLOGY (2021)

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Article Clinical Neurology

Early Stages of Alzheimer's Disease: Evolving the Care Team for Optimal Patient Management

James E. Galvin et al.

Summary: Alzheimer's disease is a progressive neurodegenerative disease that poses complex challenges for patients and caregivers. Early and accurate diagnosis is crucial for optimizing outcomes, yet many patients in the early stages remain undiagnosed due to barriers in the diagnostic journey. International experts have collaborated to create a patient-centered diagnostic blueprint for individuals in the early stages of AD.

FRONTIERS IN NEUROLOGY (2021)

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Article Clinical Neurology

Head injury and 25-year risk of dementia

Andrea L. C. Schneider et al.

Summary: The study showed a dose-dependent relationship between head injury and dementia risk, with stronger associations among female and White participants.

ALZHEIMERS & DEMENTIA (2021)

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Article Clinical Neurology

COVID-19 and dementia: Analyses of risk, disparity, and outcomes from electronic health records in the US

QuanQiu Wang et al.

Summary: Patients with dementia are at increased risk for COVID-19 compared to those without dementia, with vascular dementia carrying the highest risk. Black patients with dementia have a higher risk of COVID-19 compared to White patients.

ALZHEIMERS & DEMENTIA (2021)

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Article Geriatrics & Gerontology

The Growing Primary Care Nurse Practitioner Workforce: A Solution for the Aging Population Living With Dementia

Lusine Poghosyan et al.

Summary: Redesigning the healthcare workforce to meet the needs of the growing population of persons living with dementia, particularly those residing in the community and receiving care from primary care providers, is a national priority. The shortage of adequately trained providers is a concern, but the growing nurse practitioner (NP) workforce could bridge this gap. Evidence suggests that NPs play important roles in caring for PLWD in primary care and can increase the capacity of delivering dementia-capable primary care.

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY (2021)

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Article Nutrition & Dietetics

Associations of the Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay diet with cardiac remodelling in the community: the Framingham Heart Study

Maura E. Walker et al.

Summary: The study found an association between MIND diet score and cardiac remodelling, with varying effects on different indices of LV structure and function. This association may be influenced by cardiometabolic and lifestyle risk factors.

BRITISH JOURNAL OF NUTRITION (2021)

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Review Clinical Neurology

Alzheimer's disease associated with Down syndrome: a genetic form of dementia

Juan Fortea et al.

Summary: Adults with Down syndrome are at high risk of developing early-onset dementia, which is the leading cause of death in this population. Diagnosis of dementia remains a challenge due to lack of validated criteria, and biomarkers have shown good diagnostic performances with similar changes to Alzheimer's disease. Despite the lack of treatments to prevent Alzheimer's, unprecedented research in this area may lead to disease-modifying therapies.

LANCET NEUROLOGY (2021)

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Article Health Care Sciences & Services

High Nursing Staff Turnover In Nursing Homes Offers Important Quality Information

Ashvin Gandhi et al.

Summary: Nursing staff turnover is an important quality indicator for nursing homes. Recent data collection has allowed for the calculation of turnover rates, which were found to be correlated with facility location, ownership status, patient census, and star ratings. Disseminating this information could provide valuable insights for policymakers, payers, and consumers.

HEALTH AFFAIRS (2021)

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Article Geriatrics & Gerontology

My backpack is so heavy: Experiences of Latino caregivers of family with early-onset Alzheimer's

Mellissa Withers et al.

Summary: The study revealed that Latino caregivers of persons with EOAD face significant stress and lack of information and support services. They often lack knowledge on providing appropriate care and struggle to obtain an accurate diagnosis from physicians. Therefore, tailored programs for these caregivers are crucial.

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2021)

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Article Medicine, General & Internal

Evaluation of Selective Survival and Sex/Gender Differences in Dementia Incidence Using a Simulation Model

Crystal Shaw et al.

Summary: Selective survival may contribute to observed sex/gender differences in dementia incidence, but sex/gender-specific mechanisms may also play a role in understanding prevention and treatment of dementia. Further research on plausibility of selection characteristics with outcomes and potential contributions of sex/gender-specific mechanisms is needed.

JAMA NETWORK OPEN (2021)

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Article Genetics & Heredity

Cumulative Genetic Risk and APOE ε4 Are Independently Associated With Dementia Status in a Multiethnic, Population-Based Cohort

Kelly M. Bakulski et al.

Summary: The cumulative genetic risk of AD and APOE epsilon 4 are both independent predictors of dementia in European ancestry. This study provides important insight into the polygenic nature of dementia and demonstrates the utility of polygenic scores in dementia research.

NEUROLOGY-GENETICS (2021)

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Article Health Care Sciences & Services

Advance Care Planning For Medicare Beneficiaries Increased Substantially, But Prevalence Remained Low

Makayla K. Palmer et al.

Summary: Fee-for-service Medicare began reimbursing physicians for advance care planning conversations in 2016, and waived copayments for advance care planning during annual wellness visits. Although there was a substantial increase in outpatient advance care planning claims between 2016 and 2019, prevalence remained below 7.5% for all patient subgroups analyzed, with roughly half of beneficiaries receiving the service during annual wellness visits.

HEALTH AFFAIRS (2021)

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Editorial Material Medicine, General & Internal

Meeting the Challenge of Caring for Persons Living With Dementia and Their Care Partners and Caregivers A Report From the National Academies of Sciences, Engineering, and Medicine

Eric B. Larson et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Review Geriatrics & Gerontology

Telemedicine and Dementia Care: A Systematic Review of Barriers and Facilitators

Julie S. Yi et al.

Summary: This study reviewed the use of telemedicine among older adults with Alzheimer's disease and related dementia or mild cognitive impairment, finding that telemedicine is well received among patients and care partners, with support staff and care partners playing a crucial role in technology navigation. However, excluding older adults with sensory impairments may further exacerbate access to care in this population.

JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION (2021)

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Article Geriatrics & Gerontology

COVID-19 and the Need for Adult Day Services

Joseph E. Gaugler et al.

Summary: The COVID-19 pandemic has highlighted healthcare inequities in the United States, especially in care for older people. Lockdown orders have had various effects on adult day service programs, prompting recommendations to better support community-based programs.

JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION (2021)

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Article Medicine, General & Internal

Association of Timing of School Desegregation in the United States With Late-Life Cognition in the Study of Healthy Aging in African Americans (STAR) Cohort

Rachel L. Peterson et al.

Summary: This study analyzed data from 699 self-identified Black individuals aged 50 years or older in Northern California to examine the association between age of school desegregation and late-life cognition. Results showed that Black individuals with integrated school experience had higher executive function and semantic memory, suggesting that racially segregated schooling experiences may impact late-life cognition.

JAMA NETWORK OPEN (2021)

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Article Clinical Neurology

A Shortage of Neurologists - We Must Act Now

Jennifer J. Majersik et al.

Summary: In the United States, there is a significant mismatch between the demand for neurologists and neurologic services and the availability of these services. The suggested strategies to address this issue include shaping demand, enhancing workforce, and advocating for the value of neurologists. Through concerted effort and targeted interventions, this looming public health crisis can be averted.

NEUROLOGY (2021)

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Article Clinical Neurology

Mediterranean Diet, Alzheimer Disease Biomarkers, and Brain Atrophy in Old Age

Tommaso Ballarini et al.

Summary: The study found that adherence to a Mediterranean-like diet is associated with larger mediotemporal gray matter volume, better memory, and reduced amyloid and tau pathology. Mediotemporal volume mediated the relationship between diet and memory, and there was a favorable moderating effect on the associations among amyloid, tau pathology, and mediotemporal atrophy.

NEUROLOGY (2021)

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Article Health Care Sciences & Services

Lessons from the COVID-19 pandemic for improving outpatient neuropalliative care: A qualitative study of patient and caregiver perspectives

Zachary A. Macchi et al.

Summary: This study aimed to explore the impact of COVID-19 on outpatient palliative care delivery for patients with neurodegenerative diseases, particularly from the perspectives of patients and caregivers. Through qualitative analysis, four main themes emerged related to challenges faced during the pandemic, highlighting disruptions in healthcare delivery, increased needs, caregiver burden, and limitations of telecommunication. The findings suggest that there are unmet care needs during the pandemic, emphasizing the importance of addressing gaps to optimize outpatient palliative care for neurologic illness.

PALLIATIVE MEDICINE (2021)

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Review Psychology, Multidisciplinary

The Mental Health of Caregivers and Their Patients With Dementia During the COVID-19 Pandemic: A Systematic Review

Elvira Anna Carbone et al.

Summary: The COVID-19 pandemic and subsequent lockdown measures have had severe psychological consequences for caregivers of patients with dementia, worsening their mental health and increasing the psychological and physical burden, regardless of the severity of their relatives' disease, with global consequences.

FRONTIERS IN PSYCHOLOGY (2021)

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Article Multidisciplinary Sciences

Association of sleep duration in middle and old age with incidence of dementia

Severine Sabia et al.

Summary: Research indicates that short sleep duration in midlife is associated with an increased risk of late-onset dementia, and persistent short sleep duration further elevates the risk.

NATURE COMMUNICATIONS (2021)

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Article Public, Environmental & Occupational Health

We Don't Feel so Alone: A Qualitative Study of Virtual Memory Cafes to Support Social Connectedness Among Individuals Living With Dementia and Care Partners During COVID-19

Sara S. Masoud et al.

Summary: The study suggests that virtual Memory Cafes offer important benefits for families living with dementia, including positive effects on loneliness and social support. However, virtual models may not address the needs of all families, especially those lacking access to technology or with individuals experiencing late-stage dementia.

FRONTIERS IN PUBLIC HEALTH (2021)

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Article Clinical Neurology

Population estimate of people with clinical Alzheimer's disease and mild cognitive impairment in the United States (2020-2060)

Kumar B. Rajan et al.

Summary: This study estimated the prevalence of clinical Alzheimer's disease in 2020 and projected future increases, finding a more significant growth among Hispanics and Blacks.

ALZHEIMERS & DEMENTIA (2021)

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Article Geriatrics & Gerontology

Dementia Caregiver Virtual Support-An Implementation Evaluation of Two Pragmatic Models during COVID-19

Jacy A. Weems et al.

Summary: Caregivers of people with Alzheimer's and related dementias require support, and organizations have shifted from traditional in-person support groups to virtual care during the COVID-19 pandemic. Two model programs for virtual care for ADRD caregivers were described, with implementation varying among organizations but generally well-received. The virtual platforms provided enhanced connectedness for older adults, despite some challenges such as technological issues and distractions.

GERIATRICS (2021)

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Article Health Care Sciences & Services

Dementia Diagnosis Disparities by Race and Ethnicity

Pei-Jung Lin et al.

Summary: The study revealed that non-Hispanic Blacks and Hispanics are more likely to experience missed or delayed diagnosis of dementia, with longer diagnosis delays. Additionally, these two groups had poorer cognitive function and more functional limitations at the time of receiving a claims-based dementia diagnosis compared to non-Hispanic Whites.

MEDICAL CARE (2021)

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Article Clinical Neurology

Association of Short and Long Sleep Duration With Amyloid-β Burden and Cognition in Aging

Joseph R. Winer et al.

Summary: In older adults, both short and long sleep durations are associated with worse outcomes, such as greater A beta burden, more severe depressive symptoms, higher body mass index, and cognitive decline. This emphasizes the importance of maintaining adequate sleep for older adults.

JAMA NEUROLOGY (2021)

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Review Clinical Neurology

Global Prevalence of Young-Onset Dementia A Systematic Review and Meta-analysis

Stevie Hendriks et al.

Summary: This systematic review and meta-analysis found an age-standardized prevalence of YOD of 119.0 per 100,000 population, although estimates of the prevalence in low-income countries and younger age ranges remain scarce. These results should help policy makers organize sufficient health care for this subgroup of individuals with dementia.

JAMA NEUROLOGY (2021)

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Letter Medicine, General & Internal

Use of Medicare's New Reimbursement Codes for Cognitive Assessment and Care Planning, 2017-2018

Jing Li et al.

Summary: This cross-sectional study evaluates the utilization of Medicare's cognitive assessment and care planning codes in the initial 2 years since their introduction.

JAMA NETWORK OPEN (2021)

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Article Medicine, General & Internal

Association of Sleep and β-Amyloid Pathology Among Older Cognitively Unimpaired Adults

Philip S. Insel et al.

Summary: In older cognitively unimpaired adults, there is an association between nighttime sleep duration and regional Aβ pathology, with increased nighttime sleep duration linked to reduced Aβ standardized uptake value ratio. Daytime sleep may be associated with an increased risk for early Aβ accumulation, but does not compensate for the loss of nighttime sleep, demonstrating a circadian rhythm dependence of sleep in preventing Aβ accumulation.

JAMA NETWORK OPEN (2021)

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Article Clinical Neurology

Subjective cognitive decline higher among sexual and gender minorities in the United States, 2015-2018

Jason D. Flatt et al.

Summary: The prevalence of subjective cognitive decline (SCD) is higher in sexual and gender minority (SGM) adults compared to non-SGM adults, with functional limitations reported among SGM adults with SCD. The impact of SGM status on SCD is attenuated after considering depression.

ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS (2021)

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Article Clinical Neurology

Asian Americans and Pacific Islanders' perspectives on participating in the CARE recruitment research registry for Alzheimer's disease and related dementias, aging, and caregiving research

Van Ta Park et al.

Summary: This study explored the perspectives of Asian Americans and Pacific Islanders on recruitment strategies and messaging for participation in aging, Alzheimer's disease and related dementias, and caregiving research. The research found that tailored recruitment strategies are necessary for different AAPI groups, with an understanding of cultural and linguistic factors to increase participation in research related to ADRD, aging, and caregiving.

ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS (2021)

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Review Clinical Neurology

Exploring costs, cost components, and associated factors among people with dementia approaching the end of life: A systematic review

Javiera Leniz et al.

Summary: This study aimed to understand the costs of care for individuals with dementia approaching the end of life. 19 studies were included in the review, with findings showing that costs of dementia care rise towards death, with factors such as gender, ethnicity, educational background, comorbidities, and cognitive impairment being associated with higher costs. Further research exploring informal care costs and costs of care outside the United States by proximity to death is needed.

ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS (2021)

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Article Geriatrics & Gerontology

Impact of COVID-19 on Dementia Caregivers and Factors Associated With their Anxiety Symptoms

Yeji Hwang et al.

Summary: The COVID-19 pandemic has had an impact on family caregivers of persons living with dementia, with anxiety symptoms affecting the functional independence scores of care recipients. Healthcare professionals should pay attention to the concerns expressed by dementia caregivers during this unprecedented time.

AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS (2021)

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Review Environmental Sciences

Exposure to Air Pollution in Relation to Risk of Dementia and Related Outcomes: An Updated Systematic Review of the Epidemiological Literature

Jennifer Weave et al.

Summary: This study updated the literature review on the association between air pollution and cognitive health, finding that high-quality studies generally supported a negative association between fine particulate matter (PM2.5) and cognitive decline, while findings related to other pollutants were inconclusive. Methodological challenges continue to be a common issue in this line of research.

ENVIRONMENTAL HEALTH PERSPECTIVES (2021)

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Review Gerontology

Systematic Review and Meta-Analysis of Racial and Ethnic Differences in Dementia Caregivers' Well-Being

Chelsea Liu et al.

Summary: This study systematically reviewed articles comparing racial/ethnic differences in psychological and physical well-being among dementia caregivers. The findings showed better psychological well-being in African American caregivers and lower physical well-being in Hispanic/Latino caregivers compared to white caregivers. The research suggests the importance of future studies using population-based samples to explore cultural differences among caregivers from diverse backgrounds.

GERONTOLOGIST (2021)

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Article Gerontology

Stress, Burden, and Well-Being in Dementia and Nondementia Caregivers: Insights From the Caregiving Transitions Study

Orla C. Sheehan et al.

Summary: Dementia and nondementia caregivers showed relatively few differences in indicators of overall well-being in this population-based sample, with dementia caregivers experiencing more stressors and burden. Special attention is needed for dementia caregivers to address dementia-specific issues.

GERONTOLOGIST (2021)

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Review Gerontology

Deeply Discrediting: A Systematic Review Examining the Conceptualizations and Consequences of the Stigma of Working in Aged Care

Asmita Manchha et al.

Summary: The stigma of working in aged care is often manifested through unfavorable character judgments of aged care workers, lower value placed on aged care work, and negative emotional reactions towards working in this field. Stigma is associated with adverse psychological and job-related consequences, but only a minority of articles explicitly used the term “stigma” when discussing this issue.

GERONTOLOGIST (2021)

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Article Clinical Neurology

Mediterranean Diet, Alzheimer Disease Biomarkers, and Brain Atrophy in Old Age

Tommaso Ballarini et al.

Summary: The study found a positive association between adherence to a Mediterranean-like diet and brain structure, cognitive function, and Alzheimer's disease-related biomarkers. Greater adherence to MeDi was linked to better memory, reduced AD pathology, and larger gray matter volume in the brain.

NEUROLOGY (2021)

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Article Clinical Neurology

A Shortage of Neurologists - We Must Act Now A Report From the AAN 2019 Transforming Leaders Program

Jennifer J. Majersik et al.

Summary: In almost every US state, there is a significant mismatch between the demand for neurologists and neurological services and the available number of neurologists to provide these services. This mismatch poses challenges to patient care, outcomes, and quality of life for neurologists. To address this issue, it is essential to implement aggressive and sustained efforts to ensure the future health of patients and the specialty of neurology.

NEUROLOGY (2021)

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Article Public, Environmental & Occupational Health

Healthy Aging Requires a Healthy Home Care Workforce: the Occupational Safety and Health of Home Care Aides

M. M. Quinn et al.

Summary: Home care aide occupational safety and health hazards play a significant role in both the well-being of the aides and the quality of care services provided. Recent findings highlight challenges such as job-specific hazards, workforce shortages, and social inequities faced by aides. It is essential for government, industry, and labor to collaborate on comprehensive research programs to address these issues and improve the safety and health of both aides and clients.

CURRENT ENVIRONMENTAL HEALTH REPORTS (2021)

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Article Gerontology

Patterns of Dyadic Appraisal of Decision-Making Involvement of African American Persons Living With Dementia

Kalisha Bonds et al.

Summary: The study found a relationship between appraisal of decision-making involvement and quality of life in African American dementia dyads, identifying three distinct patterns. PLWDs in the Congruent, PLWD High Involvement pattern were younger and had less cognitive impairment, while those in Incongruent patterns showed significant differences in quality of life. Further strategies may be needed to improve the quality of life for PLWDs in different appraisal patterns.

GERONTOLOGIST (2021)

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Review Gerontology

Personhood and Dementia Care: A Qualitative Evidence Synthesis of the Perspectives of People With Dementia

Niamh Hennelly et al.

Summary: People with dementia reaffirm their personhood through personal interactions and continued engagement in social and occupational roles, while experiencing changes due to being cared for in different settings. The focus should be on protecting rather than undermining the person and their personhood, with relationships enhanced rather than diminished by formal care processes.

GERONTOLOGIST (2021)

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Article Gerontology

Elevated Risk of Cognitive Impairment Among Older Sexual Minorities: Do Health Conditions, Health Behaviors, and Social Connections Matter?

Ning Hsieh et al.

Summary: Cognitive impairment prevalence is significantly higher among sexual minority older adults compared to heterosexual older adults, with depressive symptoms explaining some of this disparity. Anxiety symptoms, physical comorbidities, health behaviors, and social connections do not fully explain the cognitive disparity by sexual orientation.

GERONTOLOGIST (2021)

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Article Gerontology

Making Sense of a Disease That Makes No Sense: Understanding Alzheimer's Disease and Related Disorders Among Caregivers and Providers Within Alaska Native Communities

Jordan P. Lewis et al.

Summary: The research reveals concerns from Alaska Native caregivers and healthcare providers about the lack of understanding, resources, and awareness of ADRD in their communities. They recognized the importance of early diagnosis, blending Western and traditional medicine, lifestyle and dietary changes, and training for caregivers. Healthcare providers also expressed the need for culturally relevant training to better serve Alaska Native populations.

GERONTOLOGIST (2021)

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Article Medicine, General & Internal

Prevalence and correlates of stress and burnout among US healthcare workers during the COVID-19 pandemic: A national cross-sectional survey study

Kriti Prasad et al.

Summary: The COVID-19 pandemic has significantly increased stress levels among healthcare workers, particularly nursing assistants, medical assistants, social workers, women, and people of color. Feeling valued and appreciated by organizations can reduce the risk of burnout among healthcare workers.

ECLINICALMEDICINE (2021)

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Review Psychology, Multidisciplinary

Assistive Technologies in Dementia Care: An Updated Analysis of the Literature

Alessandro Pappada et al.

Summary: The study found that technology can help both dementia patients and caregivers overcome physical and environmental issues, bringing benefits to mental health, skills learning, and social aspects. However, it also revealed the lack of a common methodological background, highlighting the need for further standardized research to improve the implementation of technology while maintaining personalization.

FRONTIERS IN PSYCHOLOGY (2021)

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Article Economics

Gender differences in couples' division of childcare, work and mental health during COVID-19

Gema Zamarro et al.

Summary: Research has shown that women shoulder a heavier burden in childcare during the COVID-19 crisis, even while still working. The current working situations of mothers seem to have limited influence on their provision of childcare. The division of childcare is associated with reduced working hours and an increased risk of transitioning out of employment for working mothers.

REVIEW OF ECONOMICS OF THE HOUSEHOLD (2021)

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Article Geriatrics & Gerontology

Association of Hospitalization with Long-Term Cognitive Trajectories in Older Adults

Juraj Sprung et al.

Summary: Hospitalization in older adults is associated with accelerated decline in global cognitive function and domain-specific cognitive domains, with the rate of decline dependent on admission type.

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2021)

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Article Clinical Neurology

APOE alleles' associationwith cognitive function differs across Hispanic/Latino groups and genetic ancestry in the study of Latinos-investigation of neurocognitive aging (HCHS/SOL)

Einat Granot-Hershkovitz et al.

Summary: The study found that APOE ε4 is associated with an increased risk of cognitive decline in Latinos, with varying effects across different Latino backgrounds, and Amerindian genetic ancestry can protect against the risk conferred by APOE ε4 on cognitive decline.

ALZHEIMERS & DEMENTIA (2021)

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Article Gerontology

Change in Social Engagement among Incident Caregivers and Controls: Findings from the Caregiving Transitions Study

Chelsea Liu et al.

Summary: The study found that incident caregivers had lower satisfaction with social activities and experienced greater decline in social network size compared to controls. Specifically, caregivers of dementia patients reported a more significant decrease in social network size, while spousal caregivers, those experiencing higher strain, and those providing more caregiving hours reported lower satisfaction with social activities.

JOURNAL OF AGING AND HEALTH (2021)

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Article Gerontology

Associations Between Alzheimer's Disease and Related Dementias and Depressive Symptoms of Partner Caregivers

Melissa L. Harris et al.

Summary: This study found that having a partner with ADRD was associated with a 30% increase in depressive symptoms, while a less recent diagnosis led to a 33% increase and a recent diagnosis led to a 27% increase. This emphasizes the importance of prioritizing partner health and family-centered care following an ADRD diagnosis.

JOURNAL OF APPLIED GERONTOLOGY (2021)

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Article Gerontology

Effectiveness of Reducing Disability in Alzheimer's Disease Among Dyads With Moderate Dementia

Jaime Perales-Puchalt et al.

Summary: This study evaluated the effectiveness of the Kansas City implementation of the Reducing Disability in Alzheimer's Disease (RDAD) program, which targeted dyads with moderate dementia and caregivers, resulting in improvements in behavioral symptoms, physical activity, unmet needs, behavioral symptom distress, and caregiver strain from baseline to post-intervention. These findings suggest that the adapted RDAD intervention led to clinically meaningful improvements and may be scalable.

JOURNAL OF APPLIED GERONTOLOGY (2021)

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Article Gerontology

Accentuate the Positive: The Association Between Informal and Formal Supports and Caregiving Gains

Amanda N. Leggett et al.

Summary: Emotional support from friends/family is significantly associated with greater caregiving gains, and attending a caregiver training program is only beneficial for male caregivers in terms of increasing gains.

JOURNAL OF APPLIED GERONTOLOGY (2021)

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Article Gerontology

A dementia-friendly church: How can the African American church support families affected by dementia?

Fayron Epps et al.

Summary: Dementia, including Alzheimer's disease, is impacting the African American community at alarming rates, and many churches are not equipped to support families living with dementia. This study explores characteristics of a dementia-friendly church, providing insights for African American churches and families, as well as families living with dementia outside of African American faith communities.

DEMENTIA-INTERNATIONAL JOURNAL OF SOCIAL RESEARCH AND PRACTICE (2021)

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Article Gerontology

In Our Community, Dementia Speaks: Pilot of a person-centered training targeting African-American caregivers of persons-living with dementia (innovative practice)

M. Aaron Guest et al.

Summary: African-Americans have higher rates of Alzheimer's disease and related dementias, leading to a need for culturally tailored caregiver programs. While initial results did not show significant knowledge increase, a more detailed analysis indicated success in changing caregivers' attitudes and behaviors towards the disease. The findings provide guidance for future interventions and enhancements to existing programs.

DEMENTIA-INTERNATIONAL JOURNAL OF SOCIAL RESEARCH AND PRACTICE (2021)

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Article Gerontology

Utilizing the Senior Companion Program as a platform for a culturally informed caregiver intervention: Results from a mixed methods pilot study

Noelle L. Fields et al.

Summary: The Senior Companion Program Plus was developed as an intervention for African American Alzheimer's disease and related dementia caregivers, aiming to improve caregiver burden, stress, coping skills, and social support. Results showed improvements in social support and well-being for caregivers, indicating promise for this intervention.

DEMENTIA-INTERNATIONAL JOURNAL OF SOCIAL RESEARCH AND PRACTICE (2021)

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Article Geriatrics & Gerontology

Advocating Every Single Day so as Not to Be Forgotten: Factors Supporting Resiliency in Adult Day Service Centers Amidst COVID-19-Related Closures

Tina Sadarangani et al.

Summary: The study found that closures of ADCs during the pandemic led to declines in the physical, cognitive, and mental health of users and increased caregiver strain. Access to support capital was crucial in buffering the impacts of the pandemic on ADCs. Further research is urgently needed to quantify the effects of the pandemic on ADC users and caregivers for informing post-pandemic policy and advocacy efforts.

JOURNAL OF GERONTOLOGICAL SOCIAL WORK (2021)

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Article Health Care Sciences & Services

Burden of caring for Alzheimer's disease or dementia patients in Japan, the US, and EU: results from the National Health and Wellness Survey: a cross-sectional survey

Shinya Ohno et al.

Summary: This study compares the burden of Alzheimer's disease/dementia caregivers in Japan, Europe, and the United States, finding that caregivers in Japan have lower burden potentially due to national policies supporting long-term healthcare and institutionalized nursing care facilities.

JOURNAL OF MEDICAL ECONOMICS (2021)

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Article Geriatrics & Gerontology

Relationship of Early-Life Residence and Educational Experience to Level and Change in Cognitive Functioning: Results of the Minority Aging Research Study

Melissa Lamar et al.

JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES (2020)

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Article Geriatrics & Gerontology

Change Over Time in Caregiving Networks for Older Adults With and Without Dementia

Brenda C. Spillman et al.

JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES (2020)

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Article Emergency Medicine

Comorbid conditions and emergency department treat and release utilization in multimorbid persons with cognitive impairment

Janet L. MacNeil-Vroomen et al.

AMERICAN JOURNAL OF EMERGENCY MEDICINE (2020)

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Review Geriatrics & Gerontology

Emerging Collaborative Care Models for Dementia Care in the Primary Care Setting: A Narrative Review

Hannah Heintz et al.

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY (2020)

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Article Geriatrics & Gerontology

Sources of Caregiving Burden in Middle-Aged and Older Latino Caregivers

Guilherme Moraes Balbim et al.

JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY (2020)

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Article Clinical Neurology

Leisure activity and social integration mitigate the risk of dementia related to cardiometabolic diseases: A population-based longitudinal study

Zhida Wang et al.

ALZHEIMERS & DEMENTIA (2020)

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Article Clinical Neurology

Duration of American Football Play and Chronic Traumatic Encephalopathy

Jesse Mez et al.

ANNALS OF NEUROLOGY (2020)

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Article Geriatrics & Gerontology

Medical Comorbidities of Dementia: Links to Caregivers' Emotional Difficulties and Gains

Courtney A. Polenick et al.

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2020)

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Article Health Care Sciences & Services

Implications Of The Rapid Growth Of The Nurse Practitioner Workforce In The US

David I. Auerbach et al.

HEALTH AFFAIRS (2020)

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Article Clinical Neurology

The characterisation of subjective cognitive decline

Frank Jessen et al.

LANCET NEUROLOGY (2020)

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Review Multidisciplinary Sciences

Sex and gender differences in caregiving burden experienced by family caregivers of persons with dementia: A systematic review

Chen Xiong et al.

PLOS ONE (2020)

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Review Clinical Neurology

Obstructive sleep apnea, cognition and Alzheimer's disease: A systematic review integrating three decades of multidisciplinary research

Omonigho M. Bubu et al.

SLEEP MEDICINE REVIEWS (2020)

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Article Geriatrics & Gerontology

Residential Setting and the Cumulative Financial Burden of Dementia in the 7 Years Before Death

Amy S. Kelley et al.

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2020)

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Article Geriatrics & Gerontology

A comprehensive meta-review of systematic reviews and meta-analyses on nonpharmacological interventions for informal dementia caregivers

Sheung-Tak Cheng et al.

BMC GERIATRICS (2020)

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Article Clinical Neurology

Association of Racial Residential Segregation Throughout Young Adulthood and Cognitive Performance in Middle-aged Participants in the CARDIA Study

Michelle R. Caunca et al.

JAMA NEUROLOGY (2020)

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Article Clinical Neurology

Association of Factors With Elevated Amyloid Burden in Clinically Normal Older Individuals

Reisa A. Sperling et al.

JAMA NEUROLOGY (2020)

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Article Health Care Sciences & Services

The Effect of Physical and Cognitive Impairments on Caregiving

Eric Jutkowitz et al.

MEDICAL CARE (2020)

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Article Biochemistry & Molecular Biology

A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer's disease

Nicolas R. Barthelemy et al.

NATURE MEDICINE (2020)

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Review Geriatrics & Gerontology

Effectiveness of online dementia caregivers training programs: A systematic review

Michelle Pleasant et al.

GERIATRIC NURSING (2020)

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Article Health Care Sciences & Services

Trends In Hospitals And Skilled Nursing Facilities Sharing Medical Providers, 2008-16

Elizabeth M. White et al.

HEALTH AFFAIRS (2020)

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Article Geriatrics & Gerontology

Family caregiving in the community up to 8-years after onset of dementia

Eric Jutkowitz et al.

BMC GERIATRICS (2020)

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Article Family Studies

Missing the Mark: The Complexity of African American Dementia Family Caregiving

Glenna S. Brewster et al.

JOURNAL OF FAMILY NURSING (2020)

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Article Medicine, General & Internal

Association of Demographic and Early-Life Socioeconomic Factors by Birth Cohort With Dementia Incidence Among US Adults Born Between 1893 and 1949

Sarah E. Tom et al.

JAMA NETWORK OPEN (2020)

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Review Health Care Sciences & Services

Internet-Based Supportive Interventions for Family Caregivers of People With Dementia: Systematic Review and Meta-Analysis

Minmin Leng et al.

JOURNAL OF MEDICAL INTERNET RESEARCH (2020)

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Article Geriatrics & Gerontology

Family Communication in Long-Term Care During a Pandemic: Lessons for Enhancing Emotional Experiences

Joan K. Monin et al.

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY (2020)

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Article Geriatrics & Gerontology

Family Caregiving at the End of Life and Hospice Use: A National Study of Medicare Beneficiaries

Vedika Kumar et al.

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2020)

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Review Medicine, General & Internal

Dementia prevention, intervention, and care: 2020 report of the Lancet Commission

Gill Livingston et al.

LANCET (2020)

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Article Clinical Neurology

Plasma neurofilament light chain in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: a cross-sectional and longitudinal cohort study

Yakeel T. Quiroz et al.

LANCET NEUROLOGY (2020)

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Article Clinical Neurology

Twenty-seven-year time trends in dementia incidence in Europe and the United States The Alzheimer Cohorts Consortium

Frank J. Wolters et al.

NEUROLOGY (2020)

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Article Multidisciplinary Sciences

The transition to family caregiving and its effect on biomarkers of inflammation

David L. Roth et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Public, Environmental & Occupational Health

Promoting dementia awareness in African-American faith communities

Fayron Epps et al.

PUBLIC HEALTH NURSING (2020)

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Review Neurosciences

The Trajectory of Caregiver Burden and Risk Factors in Dementia Progression: A Systematic Review

Robin van den Kieboom et al.

JOURNAL OF ALZHEIMERS DISEASE (2020)

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Article Geriatrics & Gerontology

Association of Positive Delirium Screening with Incident Dementia in Skilled Nursing Facilities

Becky A. Briesacher et al.

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2020)

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Article Geriatrics & Gerontology

Recommendations to Improve Payment Policies for Comprehensive Dementia Care

Kristin Lees Haggerty et al.

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2020)

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Article Clinical Neurology

Estimates of the Association of Dementia With US Mortality Levels Using Linked Survey and Mortality Records

Andrew C. Stokes et al.

JAMA NEUROLOGY (2020)

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Article Public, Environmental & Occupational Health

EARNING THE TRUST OF AFRICAN AMERICAN COMMUNITIES TO INCREASE REPRESENTATION IN DEMENTIA RESEARCH

Elena Portacolone et al.

ETHNICITY & DISEASE (2020)

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Article Geriatrics & Gerontology

Racial and ethnic patterns and differences in health care expenditures among Medicare beneficiaries with and without cognitive deficits or Alzheimer's disease and related dementias

Sungchul Park et al.

BMC GERIATRICS (2020)

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Review Gerontology

Effective interventions for depressive symptoms among caregivers of people with dementia: A systematic review and meta-analysis

Mijung Lee et al.

DEMENTIA-INTERNATIONAL JOURNAL OF SOCIAL RESEARCH AND PRACTICE (2020)

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Article Clinical Neurology

Association of work-family experience with mid- and late-life memory decline in US women

Elizabeth Rose Mayeda et al.

NEUROLOGY (2020)

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Article Geriatrics & Gerontology

Effectiveness of the Care of Persons With Dementia in Their Environments Intervention When Embedded in a Publicly Funded Home- and Community-Based Service Program

Richard H. Fortinsky et al.

INNOVATION IN AGING (2020)

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Review Gerontology

How Effective Are Dementia Caregiver Interventions? An Updated Comprehensive Meta-Analysis

Erik Walter et al.

GERONTOLOGIST (2020)

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Review Gerontology

Dementia Caregiving Research: Expanding and Reframing the Lens of Diversity, Inclusivity, and Intersectionality

Peggye Dilworth-Anderson et al.

GERONTOLOGIST (2020)

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Article Gerontology

Race Differences in Characteristics and Experiences of Black and White Caregivers of Older Americans

Chanee D. Fabius et al.

GERONTOLOGIST (2020)

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Article Geriatrics & Gerontology

Physician assistants in geriatric medical care

Andrzej Kozikowski et al.

BMC GERIATRICS (2020)

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Article Gerontology

Till Death Do Us Part: Intersecting Health and Spousal Dementia Caregiving on Caregiver Mortality

Amanda N. Leggett et al.

JOURNAL OF AGING AND HEALTH (2020)

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Article Gerontology

The Effect of the Great Village on Psychological Outcomes, Burden, and Mastery in African American Caregivers of Persons Living With Dementia

Glenna S. Brewster et al.

JOURNAL OF APPLIED GERONTOLOGY (2020)

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Article Gerontology

Community-Engaged Research with Vietnamese Americans to Pilot-Test a Dementia Caregiver Intervention

Oanh L. Meyer et al.

JOURNAL OF CROSS-CULTURAL GERONTOLOGY (2020)

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Article Gerontology

Racial Differences in Respite Use among Black and White Caregivers for People Living with Dementia

Lauren J. Parker et al.

JOURNAL OF AGING AND HEALTH (2020)

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Article Psychology, Clinical

A review of minority stress as a risk factor for cognitive decline in lesbian, gay, bisexual, and transgender (LGBT) elders

Anthony N. Correro et al.

JOURNAL OF GAY & LESBIAN MENTAL HEALTH (2020)

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Article Psychology, Clinical

Impact of COVID-19 Pandemic Restrictions on Community-Dwelling Caregivers and Persons With Dementia

Nicole E. Greenberg et al.

PSYCHOLOGICAL TRAUMA-THEORY RESEARCH PRACTICE AND POLICY (2020)

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Article Gerontology

Social Determinants of Health: Underreported Heterogeneity in Systematic Reviews of Caregiver Interventions

Heather M. Young et al.

GERONTOLOGIST (2020)

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Article Gerontology

Stressors and Resources Related to Medication Management: Associations With Spousal Caregivers' Role Overload

Courtney A. Polenick et al.

GERONTOLOGIST (2020)

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Review Gerontology

The Effectiveness of Nonpharmacological Interventions for Informal Dementia Caregivers: An Updated Systematic Review and Meta-Analysis

Sheung-Tak Cheng et al.

PSYCHOLOGY AND AGING (2020)

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Article Clinical Neurology

Changes in physical and mental health of Black, Hispanic, and White caregivers and non-caregivers associated with onset of spousal dementia

Cynthia Chen et al.

ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS (2020)

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Article Clinical Neurology

2020 Alzheimer's disease facts and figures

[Anonymous]

ALZHEIMERS & DEMENTIA (2020)

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Review Clinical Neurology

Whitepaper: Defining and investigating cognitive reserve, brain reserve, and brain maintenance

Yaakov Stern et al.

ALZHEIMERS & DEMENTIA (2020)

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Article Medicine, Legal

Wandering Dementia-A Syndrome with Forensic Implications

Roger W. Byard et al.

JOURNAL OF FORENSIC SCIENCES (2019)

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Article Clinical Neurology

Treatment patterns and burden of behavioral disturbances in patients with dementia in the United States: a claims database analysis

Myrlene Sanon Aigbogun et al.

BMC NEUROLOGY (2019)

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Review Cardiac & Cardiovascular Systems

The Mediterranean Diet and Cardiovascular Health A Critical Review

Miguel A. Martinez-Gonzalez et al.

CIRCULATION RESEARCH (2019)

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Article Health Care Sciences & Services

Medicare expenditures attributable to dementia

Lindsay White et al.

HEALTH SERVICES RESEARCH (2019)

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Review Geriatrics & Gerontology

Depression in carers of people with dementia from a minority ethnic background: Systematic review and meta-analysis of randomised controlled trials of psychosocial interventions

Nazire E. Akarsu et al.

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY (2019)

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Air Pollution and Dementia: A Systematic Review

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Cognitive Reserve in Midlife is not Associated with Amyloid-β Deposition in Late-Life

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Cognitive and physical activity and dementia A 44-year longitudinal population study of women

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Reproductive period and risk of dementia in a diverse cohort of health care members

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Denial of Human Rights: We Must Change the Paradigm of Dementia Care

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Association of Amyloid Positron Emission Tomography With Subsequent Change in Clinical Management Among Medicare Beneficiaries With Mild Cognitive Impairment or Dementia

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Association Between Caregiver Depression and Emergency Department Use Among Patients With Dementia

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Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease: A Longitudinal Study

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Longitudinal analysis of dementia diagnosis and specialty care among racially diverse Medicare beneficiaries

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Traumatic Brain Injury and Risk of Long-Term Brain Changes, Accumulation of Pathological Markers, and Developing Dementia: A Review

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Interventions for reducing levels of burden amongst informal carers of persons with dementia in the community. A systematic review and meta-analysis of randomised controlled trials

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Prevalence and incidence of clinically diagnosed Alzheimer's disease dementia from 1994 to 2012 in a population study

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Attributable risk of Alzheimer's dementia attributed to age-related neuropathologies

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Prevalence and correlates of mild cognitive impairment among diverse Hispanics/Latinos: Study of Latinos-Investigation of Neurocognitive Aging results

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Association of Informal Caregiver Distress with Health Outcomes of Community-Dwelling Dementia Care Recipients: A Systematic Review

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Cognitive decline after elective and nonelective hospitalizations in older adults

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Refining caregiver vulnerability for clinical practice: determinants of self-rated health in spousal dementia caregivers

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Health Care Utilization and Cost Outcomes of a Comprehensive Dementia Care Program for Medicare Beneficiaries

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Association of Dementia With Mortality Among Adults With Down Syndrome Older Than 35 Years

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Racial Differences in Caregiving: Variation by Relationship Type and Dementia Care Status

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Sleep Duration and Sleep Quality in Caregivers of Patients With Dementia A Systematic Review and Meta-analysis

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Reappraising the Efficacy and Acceptability of Multicomponent Interventions for Caregiver Depression in Dementia: The Utility of Network Meta-Analysis

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Current and past leisure time physical activity in relation to risk of Alzheimer's disease in older adults

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The Association of Early Life Factors and Declining Incidence Rates of Dementia in an Elderly Population of African Americans

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Correlates of Subjective Cognitive Decline in Lesbian, Gay, Bisexual, and Transgender Older Adults

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Internet-Based Interventions Aimed at Supporting Family Caregivers of People With Dementia: Systematic Review

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Educational Differences in the Prevalence of Dementia and Life Expectancy with Dementia: Changes from 2000 to 2010

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Traumatic Brain Injury History Is Associated With an Earlier Age of Dementia Onset in Autopsy-Confirmed Alzheimer's Disease

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Sleep disturbances increase the risk of dementia: A systematic review and meta-analysis

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Health economic evaluations of non-pharmacological interventions for persons with dementia and their informal caregivers: a systematic review

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Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau

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Association of Mild Traumatic Brain Injury With and Without Loss of Consciousness With Dementia in US Military Veterans

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Association of Cardiovascular Health Level in Older Age With Cognitive Decline and Incident Dementia

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Comparative Effectiveness of 2 Interventions for Hispanic Caregivers of Persons with Dementia

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Over-the-Counter Supplement Interventions to Prevent Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer-Type Dementia A Systematic Review

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Traumatic brain injury history is associated with earlier age of onset of Alzheimer disease

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Association Between Midlife Vascular Risk Factors and Estimated Brain Amyloid Deposition

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Racial Differences in the Association Between Apolipoprotein E Risk Alleles and Overall and Total Cardiovascular Mortality Over 18 Years

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BRAIN IMAGING AND BEHAVIOR (2014)

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Type Of Attending Physician Influenced Feeding Tube Insertions For Hospitalized Elderly People With Severe Dementia

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Review Neurosciences

Under Reporting of Dementia Deaths on Death Certificates: A Systematic Review of Population-based Cohort Studies

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JOURNAL OF ALZHEIMERS DISEASE (2014)

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Review Neurosciences

Modifiable Lifestyle Factors in Dementia: A Systematic Review of Longitudinal Observational Cohort Studies

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JOURNAL OF ALZHEIMERS DISEASE (2014)

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Managing medications: the role of informal caregivers of older adults and people living with dementia. A review of the literature

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Neuropsychiatric Disorders and Potentially Preventable Hospitalizations in a Prospective Cohort Study of Older Americans

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NATURE (2014)

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Sex and gender differences in the causes of dementia: A narrative review

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MATURITAS (2014)

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Article Psychology, Clinical

Bilingualism Does Not Alter Cognitive Decline or Dementia Risk Among Spanish-Speaking Immigrants

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NEUROPSYCHOLOGY (2014)

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Article Public, Environmental & Occupational Health

Association between mental demands at work and cognitive functioning in the general population - results of the health study of the Leipzig research center for civilization diseases (LIFE)

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Clinical epidemiology of Alzheimer's disease: assessing sex and gender differences

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Why Does Placement of Persons With Alzheimer's Disease Into Long-Term Care Improve Caregivers' Well-Being? Examination of Psychological Mediators

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PSYCHOLOGY AND AGING (2014)

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Social Care Networks and Older LGBT Adults: Challenges for the Future

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Fidelity and acceptability of an adaptive intervention for caregivers: An exploratory study

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Potentially avoidable hospitalizations among Medicare beneficiaries with Alzheimer's disease and related disorders

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Health Disparities in Cost of Care in Patients With Alzheimer's Disease: An Analysis Across 4 State Medicaid Populations

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The Clinical and Economic Burden of Newly Diagnosed Alzheimer's Disease in a Medicare Advantage Population

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AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS (2013)

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Mild Cognitive Impairment Due to Alzheimer Disease in the Community

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ANNALS OF NEUROLOGY (2013)

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Review Psychiatry

Socioeconomic status as a risk factor for dementia death: individual participant meta-analysis of 86 508 men and women from the UK

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Mediterranean Diet, Cognitive Function, and Dementia: A Systematic Review

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EPIDEMIOLOGY (2013)

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INTENSIVE CARE MEDICINE (2013)

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Survival in dementia and predictors of mortality: a review

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INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY (2013)

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Variants in the ATP-Binding Cassette Transporter (ABCA7), Apolipoprotein E ε4, and the Risk of Late-Onset Alzheimer Disease in African Americans

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JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2013)

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Turnover, Staffing, Skill Mix, and Resident Outcomes in a National Sample of US Nursing Homes

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Caregiving Strain and All-Cause Mortality: Evidence From the REGARDS Study

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A two-decade comparison of prevalence of dementia in individuals aged 65 years and older from three geographical areas of England: results of the Cognitive Function and Ageing Study I and II

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Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study

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LANCET NEUROLOGY (2013)

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Twenty-year changes in dementia occurrence suggest decreasing incidence in central Stockholm, Sweden

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Alzheimer disease in the United States (2010-2050) estimated using the 2010 census

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New Insights into the Dementia Epidemic

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Long-Term Cognitive Impairment after Critical Illness

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NEW ENGLAND JOURNAL OF MEDICINE (2013)

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Monetary Costs of Dementia in the United States

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NEW ENGLAND JOURNAL OF MEDICINE (2013)

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Sleep Disturbance in Family Caregivers of Individuals With Dementia: A Review of the Literature

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PERSPECTIVES IN PSYCHIATRIC CARE (2013)

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Sugar for the brain: the role of glucose in physiological and pathological brain function

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TRENDS IN NEUROSCIENCES (2013)

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Diabetes mellitus and risk of dementia: A meta-analysis of prospective observational studies

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Effect of socioeconomic disparities on incidence of dementia among biracial older adults: prospective study

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BMJ-BRITISH MEDICAL JOURNAL (2013)

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Pre-Diagnosis Excess Acute Care Costs in Alzheimer's Patients among a US Medicaid Population

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APPLIED HEALTH ECONOMICS AND HEALTH POLICY (2013)

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Review Clinical Neurology

Rate of Conversion from Prodromal Alzheimer's Disease to Alzheimer's Dementia: A Systematic Review of the Literature

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DEMENTIA AND GERIATRIC COGNITIVE DISORDERS EXTRA (2013)

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Article Psychology, Clinical

Secular trends in the prevalence of dementia and depression in Swedish septuagenarians 1976-2006

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PSYCHOLOGICAL MEDICINE (2013)

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Review Health Policy & Services

The experience of providing end-of-life care to a relative with advanced dementia: An integrative literature review

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PALLIATIVE & SUPPORTIVE CARE (2013)

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Positive aspects of caregiving: More than looking on the bright side

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AGING & MENTAL HEALTH (2012)

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Agreement on Diagnosis Among Patients, Companions, and Professionals After a Dementia Evaluation

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ALZHEIMER DISEASE & ASSOCIATED DISORDERS (2012)

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Review Geriatrics & Gerontology

Interventions for Hispanic Caregivers of Patients with Dementia: A Review of the Literature

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AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS (2012)

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Delirium is a strong risk factor for dementia in the oldest-old: a population-based cohort study

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BRAIN (2012)

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A Longitudinal Analysis of the Lifetime Cost of Dementia

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HEALTH SERVICES RESEARCH (2012)

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The problem with problem behaviors: a systematic review of the association between individual patient behavioral and psychological symptoms and caregiver depression and burden within the dementia patient-caregiver dyad

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INTERNATIONAL PSYCHOGERIATRICS (2012)

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Review Psychology, Clinical

Dementia time to death: a systematic literature review on survival time and years of life lost in people with dementia

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INTERNATIONAL PSYCHOGERIATRICS (2012)

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Letter Medicine, General & Internal

Dementia From Alzheimer Disease and Mixed Pathologies in the Oldest Old

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JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2012)

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Dying in U.S. Nursing Homes with Advanced Dementia: How Does Health Care Use Differ for Residents with, versus without, End-of-Life Medicare Skilled Nursing Facility Care?

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Transitions in Care for Older Adults with and without Dementia

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JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2012)

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Prevalence of Health Conditions and Predictors of Mortality in Oldest Old Mexican Americans and Non-Hispanic Whites

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JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION (2012)

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Sex and Gender Differences in Alzheimer's Disease: Recommendations for Future Research

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Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer's disease in the presenilin 1 E280A kindred: a case-control study

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LANCET NEUROLOGY (2012)

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Cognitive reserve in ageing and Alzheimer's disease

Yaakov Stern

LANCET NEUROLOGY (2012)

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Postmenopausal hormone therapy, timing of initiation, APOE and cognitive decline

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NEUROBIOLOGY OF AGING (2012)

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Review Public, Environmental & Occupational Health

Prevalence of Apolipoprotein E4 Genotype and Homozygotes (APOE e4/4) among Patients Diagnosed with Alzheimer's Disease: A Systematic Review and Meta-Analysis

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Is dementia incidence declining? Trends in dementia incidence since 1990 in the Rotterdam Study

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NEUROLOGY (2012)

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Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

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NEW ENGLAND JOURNAL OF MEDICINE (2012)

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Effect of Chronic Dementia Caregiving and Major Transitions in the Caregiving Situation on Kidney Function: A Longitudinal Study

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PSYCHOSOMATIC MEDICINE (2012)

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Apolipoprotein E and Apolipoprotein E Receptors: Normal Biology and Roles in Alzheimer Disease

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COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)

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Delirium in the ICU: an overview

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ANNALS OF INTENSIVE CARE (2012)

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Alzheimer's disease is not brain aging: neuropathological, genetic, and epidemiological human studies

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ACTA NEUROPATHOLOGICA (2011)

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Diversity and Disparity in Dementia: The Impact of Ethnoracial Differences in Alzheimer Disease

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ALZHEIMER DISEASE & ASSOCIATED DISORDERS (2011)

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Trends in the incidence and prevalence of Alzheimer's disease, dementia, and cognitive impairment in the United States

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ALZHEIMERS & DEMENTIA (2011)

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Article Clinical Neurology

Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

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ALZHEIMERS & DEMENTIA (2011)

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Article Clinical Neurology

Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

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ALZHEIMERS & DEMENTIA (2011)

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Article Clinical Neurology

The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

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ALZHEIMERS & DEMENTIA (2011)

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Article Clinical Neurology

The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

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ALZHEIMERS & DEMENTIA (2011)

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Article Public, Environmental & Occupational Health

Changes in the Prevalence of Cognitive Impairment Among Older Americans, 1993-2004: Overall Trends and Differences by Race/Ethnicity

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AMERICAN JOURNAL OF EPIDEMIOLOGY (2011)

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Article Public, Environmental & Occupational Health

The Socioeconomic Gradient of Diabetes Prevalence, Awareness, Treatment, and Control Among African Americans in the Jackson Heart Study

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ANNALS OF EPIDEMIOLOGY (2011)

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Article Geriatrics & Gerontology

Vascular Risk Factors and Dementia: 40-Year Follow-Up of a Population-Based Cohort

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DEMENTIA AND GERIATRIC COGNITIVE DISORDERS (2011)

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Genetic counseling and testing for Alzheimer disease: Joint practice guidelines of the American College of Medical Genetics and the National Society of Genetic Counselors

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GENETICS IN MEDICINE (2011)

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Article Geriatrics & Gerontology

Caring for Individuals with Dementia and Cognitive Impairment, Not Dementia: Findings from the Aging, Demographics, and Memory Study

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Late-Life Social Activity and Cognitive Decline in Old Age

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Midlife vascular risk factor exposure accelerates structural brain aging and cognitive decline

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End-of-Life Transitions among Nursing Home Residents with Cognitive Issues

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NEW ENGLAND JOURNAL OF MEDICINE (2011)

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Socioeconomic Status and Incident Type 2 Diabetes Mellitus: Data from the Women's Health Study

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PLOS ONE (2011)

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Prevalence of dementia disorders in the oldest-old: an autopsy study

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ACTA NEUROPATHOLOGICA (2010)

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Trends in prevalence of Alzheimer's disease and vascular dementia in a Japanese community: the Hisayama Study

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ACTA PSYCHIATRICA SCANDINAVICA (2010)

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Lethality of Alzheimer Disease and Its Impact on Nursing Home Placement

Henry Michael Arrighi et al.

ALZHEIMER DISEASE & ASSOCIATED DISORDERS (2010)

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Article Clinical Neurology

Outcome over seven years of healthy adults with and without subjective cognitive impairment

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ALZHEIMERS & DEMENTIA (2010)

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Review Geriatrics & Gerontology

Developing Culturally Sensitive Dementia Caregiver Interventions: Are We There Yet?

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AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS (2010)

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Article Medicine, General & Internal

Clinically significant changes in burden and depression among dementia caregivers following nursing home admission

Joseph E. Gaugler et al.

BMC MEDICINE (2010)

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Article Medicine, General & Internal

Association Between Acute Care and Critical Illness Hospitalization and Cognitive Function in Older Adults

William J. Ehlenbach et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2010)

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Review Geriatrics & Gerontology

Genetics of Alzheimer Disease

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JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY (2010)

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Association Between Chronic Caregiving Stress and Impaired Endothelial Function in the Elderly

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JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2010)

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Article Geriatrics & Gerontology

Hospice Use and Outcomes in Nursing Home Residents with Advanced Dementia

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JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2010)

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Article Geriatrics & Gerontology

Hospitalization in Community-Dwelling Persons with Alzheimer's Disease: Frequency and Causes

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JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2010)

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Cognitive deficits and associated neurological complications in individuals with Down's syndrome

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Change in risk of Alzheimer disease over time

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NEUROLOGY (2010)

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Prevalence rates for dementia and Alzheimer's disease in African Americans: 1992 versus 2001

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ALZHEIMERS & DEMENTIA (2009)

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Cognitive performance and informant reports in the diagnosis of cognitive impairment and dementia in African Americans and whites

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ALZHEIMERS & DEMENTIA (2009)

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The Neuropathology of Probable Alzheimer Disease and Mild Cognitive Impairment

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ANNALS OF NEUROLOGY (2009)

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Midlife and Late-Life Obesity and the Risk of Dementia Cardiovascular Health Study

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ARCHIVES OF NEUROLOGY (2009)

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Serial PIB and MRI in normal, mild cognitive impairment and Alzheimers disease: implications for sequence of pathological events in Alzheimers disease

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BRAIN (2009)

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Article Geriatrics & Gerontology

Diagnosis and Treatment of Patients with Severe Alzheimer's Disease

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DRUGS & AGING (2009)

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Cause of death in patients with dementia disorders

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EUROPEAN JOURNAL OF NEUROLOGY (2009)

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The Accuracy of Medicare Claims as an Epidemiological Tool: The Case of Dementia Revisited

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JOURNAL OF ALZHEIMERS DISEASE (2009)

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Article Health Care Sciences & Services

Churning: The Association between Health Care Transitions and Feeding Tube Insertion for Nursing Home Residents with Advanced Cognitive Impairment

Joan M. Teno et al.

JOURNAL OF PALLIATIVE MEDICINE (2009)

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Article Geriatrics & Gerontology

Agreement Between Nosologist and Cardiovascular Health Study Review of Deaths: Implications of Coding Differences

Diane G. Ives et al.

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2009)

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Article Clinical Neurology

Cognitive activities delay onset of memory decline in persons who develop dementia

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NEUROLOGY (2009)

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Review Clinical Neurology

Vascular risk factors and dementia How to move forward?

Anand Viswanathan et al.

NEUROLOGY (2009)

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Editorial Material Clinical Neurology

Diagnosis and assessment of Alzheimer's disease in diverse populations

Peggye Dilworth-Anderson et al.

ALZHEIMERS & DEMENTIA (2008)

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Article Geriatrics & Gerontology

Risk-reducing effect of education in Alzheimer's disease

Sigrid Botne Sando et al.

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY (2008)

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Article Health Care Sciences & Services

Acute Care Utilization by Dementia Caregivers Within Urban Primary Care Practices

Cathy C. Schubert et al.

JOURNAL OF GENERAL INTERNAL MEDICINE (2008)

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Article Health Care Sciences & Services

Patients dying with dementia: Experience at the end of life and impact of hospice care

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JOURNAL OF PAIN AND SYMPTOM MANAGEMENT (2008)

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Article Clinical Neurology

Survival in Alzheimer disease A multiethnic, population-based study of incident cases

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NEUROLOGY (2008)

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Review Psychology, Clinical

Lifecourse Social Conditions and Racial and Ethnic Patterns of Cognitive Aging

M. Maria Glymour et al.

NEUROPSYCHOLOGY REVIEW (2008)

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Article Medicine, General & Internal

Survival times in people with dementia: analysis from population based cohort study with 14 year follow-up

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BMJ-BRITISH MEDICAL JOURNAL (2008)

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Article Clinical Neurology

Mixed brain pathologies account for most dementia cases in community-dwelling older persons

Julie A. Schneider et al.

NEUROLOGY (2007)

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Article Clinical Neurology

Reduced cerebral glucose metabolism in patients at risk for Alzheimer's disease

Aoife Hunt et al.

PSYCHIATRY RESEARCH-NEUROIMAGING (2007)

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Article Clinical Neurology

Neuropathological evaluation of mixed dementia

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JOURNAL OF THE NEUROLOGICAL SCIENCES (2007)

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Article Psychology, Clinical

Mapping the connections between education and dementia

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JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY (2007)

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Article Health Care Sciences & Services

Patterns of agricultural pesticide use in relation to socioeconomic characteristics of the population in the rural US south

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INTERNATIONAL JOURNAL OF HEALTH SERVICES (2007)

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Article Public, Environmental & Occupational Health

Prevalence of dementia in the united states: The aging, demographics, and memory study

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NEUROEPIDEMIOLOGY (2007)

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Review Clinical Neurology

The enigma of mixed dementia

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ALZHEIMERS & DEMENTIA (2007)

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Article Clinical Neurology

Hippocampal sclerosis dementia differs from hippocampal sclerosis in frontal lobe degeneration

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ACTA NEUROPATHOLOGICA (2007)

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Letter Geriatrics & Gerontology

Short-term effect of dementia disclosure: How patients and families describe the diagnosis

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Leisure-time exercise and overall physical activity in older women caregivers and non-caregivers from the caregiver-SOF study

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Neuropathology of older persons without cognitive impairment from two community-based studies

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Gender differences in caregiver stressors, social resources, and health: An updated meta-analysis

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Post-operative delirium is associated with poor cognitive outcome and dementia

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Mental, physical and social components in leisure activities equally contribute to decrease dementia risk

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DEMENTIA AND GERIATRIC COGNITIVE DISORDERS (2006)

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Impediments to timely diagnosis of Alzheimer's disease in African Americans

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Families filling the gap: Comparing family involvement for assisted living and nursing home residents with dementia

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A systematic review of prevalence studies of dementia in Parkinson's disease

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MOVEMENT DISORDERS (2005)

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ARCHIVES OF NEUROLOGY (2005)

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Ethnic differences in stressors, resources, and psychological outcomes of family caregiving:: A meta-analysis

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ANNALS OF INTERNAL MEDICINE (2004)

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Incidence and prevalence of dementia in the cardiovascular health study

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Long-term care placement of dementia patients and caregiver health and well-being

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Prevalence of blood lead levels ≥5 μg/dL among US children 1 to 5 years of age and socioeconomic and demographic factors associated with blood of lead levels 5 to 10 μg/dL, Third National Health and Nutrition Examination Survey, 1988-1994

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PEDIATRICS (2003)

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End-of-life care and the effects of bereavement on family caregivers of persons with dementia

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Review Psychology

Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: Conceptual issues and research evidence

IH Meyer

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Prevalence of dementia in three ethnic groups: The south Florida program on aging and health

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ANNALS OF EPIDEMIOLOGY (2003)

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Prevalence of dementia in older Latinos: The influence of type 2 diabetes mellitus, stroke and genetic factors

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Incidence of Alzheimer disease in a biracial urban community - Relation to apolipoprotein E allele status

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Neuropathology of cognitively normal elderly

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Is caregiving hazardous to one's physical health? A meta-analysis

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The incremental direct costs associated with behavioral symptoms in AD

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Survival following a diagnosis of Alzheimer disease

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Dementia and Alzheimer disease incidence - A prospective cohort study

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ARCHIVES OF NEUROLOGY (2002)

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A path model of chronic stress, the metabolic syndrome, and coronary heart disease

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Risk of dementia among white and African American relatives of patients with Alzheimer disease

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JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2002)

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What is cognitive reserve? Theory and research application of the reserve concept

Y Stern

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Annual incidence of Alzheimer disease in the United States projected to the years 2000 through 2050

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ALZHEIMER DISEASE & ASSOCIATED DISORDERS (2001)

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Frequency of Alzheimer's disease and other dementias in a community outreach sample of Hispanics

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Hospice enrollment and hospitalization of dying nursing home patients

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Dementia and race: Are there differences between African Americans and Caucasians?

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Is the risk of developing Alzheimer's disease greater for women than for men?

LE Hebert et al.

AMERICAN JOURNAL OF EPIDEMIOLOGY (2001)

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Documented head injury in early adulthood and risk of Alzheimer's disease and other dementias

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Age-specific incidence rates of Alzheimer's disease - The Baltimore Longitudinal Study of Aging

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