Pharmacotherapy of obesity-Competition to bariatric surgery or a meaningful supplement?

Obesity is a complex chronic disease and requires a long-term multimodal approach. The current treatment algorithm for treatment of obesity mainly consists of a stepwise approach, which starts with a lifestyle intervention followed by or combined with medication treatment, whereas bariatric surgery is often reserved for the last option. This article provides an overview of the currently available conservative medicinal treatment regimens and the currently approved medications as well as medications currently undergoing approval studies with respect to the efficacy and possible side effects. Special attention is paid to the importance of combination treatment of pharmacotherapy and surgery in the sense of a multimodal treatment. The data so far show that using a multimodal approach an improvement in the long-term weight loss and metabolic benefits can be achieved for the patients.

Automated summary

Obesity requires a long-term multimodal approach, starting with lifestyle intervention and potentially combining medication and surgery. This article provides an overview of conservative medicinal treatment regimens, approved medications, and ongoing studies, emphasizing the importance of combination treatment. Data suggests that a multimodal approach can lead to long-term weight loss and metabolic benefits for patients.