4.7 Article

Bevacizumab plus FOLFIRI after failure of platinum- etoposide first-line chemotherapy in patients with advanced neuroendocrine carcinoma (PRODIGE 41-BEVANEC) : a randomised, multicentre, non-comparative, open-label, phase 2 trial

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Oncology

External control arms in oncology: current use and future directions

P. S. Mishra-Kalyani et al.

Summary: This paper introduces the concept of external controls in oncology trials and reviews relevant research on this topic. It discusses the use of external control data to expand the interpretability of experimental results when a randomized design is not feasible. The paper also provides general considerations for designing trials that incorporate external control data and presents case studies of marketing applications that included external control data submitted to the Food and Drug Administration.

ANNALS OF ONCOLOGY (2022)

Article Oncology

The molecular characteristics of high-grade gastroenteropancreatic neuroendocrine neoplasms

Andreas Venizelos et al.

Summary: High-grade gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN) are a rare and understudied type of tumors, with a very poor prognosis. Molecular analysis of 181 HG GEP-NEN patients revealed unique genetic alterations and copy number changes in different subgroups of tumors, indicating potential personalized treatment options. Limited similarities were found with small-cell lung cancer (SCLC), suggesting the need for subtype-specific therapeutic approaches.

ENDOCRINE-RELATED CANCER (2022)

Article Oncology

Second-line treatment and prognostic factors in neuroendocrine carcinoma: the RBNEC study

Julien Hadoux et al.

Summary: This study reports the results of second-line chemotherapy with etoposide based rechallenge (EBR) in neuroendocrine carcinoma (NEC) patients. It also investigates the prognostic role of RB1 status in this context. The study found that RB1 status does not affect prognosis in NEC patients receiving second-line chemotherapy. However, EBR may be the best option for patients with an initial response to first-line platinum-etoposide chemotherapy lasting at least 3 months.

ENDOCRINE-RELATED CANCER (2022)

Article Endocrinology & Metabolism

ctDNA in Neuroendocrine Carcinoma of Gastroenteropancreatic Origin or of Unknown Primary: The CIRCAN-NEC Pilot Study

Laura Gerard et al.

Summary: This study aimed to describe ctDNA mutations in GEPNEC patients and assess their predictive value for response to chemotherapy and disease progression. The results showed a high sensitivity of ctDNA assessment, which is expected to play an important role in the future management of GEPNEC.

NEUROENDOCRINOLOGY (2021)

Article Gastroenterology & Hepatology

FOLFIRINEC: a randomized phase II trial of mFOLFIRINOX vs platinum-etoposide for metastatic neuroendocrine carcinoma of gastroenteropancreatic or unknown origin

Julien Hadoux et al.

Summary: This study aims to compare the survival and quality of life of patients with neuroendocrine carcinoma under different chemotherapy regimens through a randomized allocation of 218 patients. Recruitment started on October 20, 2020 and the study is ongoing.

DIGESTIVE AND LIVER DISEASE (2021)

Review Oncology

Extrapulmonary poorly differentiated NECs, including molecular and immune aspects

Mairead G. McNamara et al.

ENDOCRINE-RELATED CANCER (2020)

Article Oncology

Bevacizumab-based Chemotherapy for Poorly-differentiated Neuroendocrine Tumors

Thomas Collot et al.

ANTICANCER RESEARCH (2018)

Review Oncology

Gastroenteropancreatic High-Grade Neuroendocrine Carcinoma

Halfdan Sorbye et al.

CANCER (2014)

Article Endocrinology & Metabolism

Angiogenesis in Neuroendocrine Tumors: Therapeutic Applications

Jean-Yves Scoazec

NEUROENDOCRINOLOGY (2013)

Article Endocrinology & Metabolism

Quality of Clinical Trials in Gastroenteropancreatic Neuroendocrine Tumours

Thomas Walter et al.

NEUROENDOCRINOLOGY (2012)