Enhanced Logical Stochastic Resonance in Synthetic Genetic Networks

In this brief, the concept of logical stochastic resonance is applied to implement the Set-Reset latch in a synthetic gene network derived from a bacteriophage lambda. Clear Set-Reset latch operation is obtained when the network is only subjected to periodic forcing. The correct probability of obtaining the desired logic operation first increases to unity and then decreases as the amplitude of the periodic forcing increases. In addition, the output logic operation can be easily morphed by tuning the frequency and the amplitude of the periodic forcing. At the same time, we indicate that adding moderate periodic forcing to the background Gaussian noise may increase the length of the optimal plateau of getting the desired logic operation in genetic regulatory network. We also point out that robust Set-Reset latch operation can be obtained using the interplay of periodic forcing and background noise when the noise strength is lower than what is required.