期刊
HUMAN GENE THERAPY METHODS
卷 27, 期 1, 页码 13-16出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/hgtb.2015.129
关键词
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资金
- NIH-NINDS [R01NS073940]
Accessing cerebrospinal fluid (CSF) from the craniocervical junction through the posterior atlanto-occipital membrane via cerebellomedullary injection (also known as cisternal puncture or cisterna magna injection) has become a standard procedure in preclinical studies. Such delivery provides broader coverage to the central and peripheral nervous system unlike local parenchymal delivery alone. As a clinical application, this approach offers a more reliable method for neurological gene replacement delivery in infants, where skull-mounted devices are not indicated. Here we describe a consistent, precise, and safe method for CSF injection with minimal equipment and technical skills.
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