Cells in developing embryos differentiate reliably despite fluctuations in morphogen concentrations and molecular processes, by utilizing cell-cell interactions and the asymmetry in gene response to global morphogen signals. This bimodal response ensures consistent developmental outcomes and reduces uncertainty in boundary locations between distinct fates.
Cells in developing embryos reliably differentiate to attain location-specific fates, despite fluctuations in morphogen concentrations that provide positional information and in molecular processes that interpret it. We show that local contact-mediated cell-cell interactions utilize inherent asymmetry in the response of patterning genes to the global morphogen signal yielding a bimodal response. This results in robust developmental outcomes with a consistent identity for the dominant gene at each cell, substantially reducing the uncertainty in the location of boundaries between distinct fates.
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