Splenic stromal niches in homeostasis and immunity

Article Immunology

CXCL10 chemokine regulates heterogeneity of the CD8+ T cell response and viral set point during chronic infection

Aleksandra J. Ozga et al.

Summary: The differentiation of CD8(+) T cells in chronic infection is controlled by CXCR3 and CXCL10, which has important therapeutic implications.

IMMUNITY (2022)

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Review Immunology

Chemo- and mechanosensing by dendritic cells facilitate antigen surveillance in the spleen

Dan Liu et al.

Summary: Dendritic cells in the spleen play a critical role in initiating adaptive immune responses against blood-borne invaders. This review focuses on the positioning and function of conventional DC2 (cDC2) and discusses the contribution of chemoattractant receptors and integrins. The newly identified role of adhesion G-protein coupled receptor E5 (Adgre5 or CD97) and its ligand CD55 in cDC2 positioning and homeostasis is detailed, as well as the activation and migration of cDC2 to engage helper T cells.

IMMUNOLOGICAL REVIEWS (2022)

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Article Neurosciences

Neuron-derived neuropeptide Y fine-tunes the splenic immune responses

Jinsong Yu et al.

Summary: The nervous and immune systems are connected, with NPY playing a role in regulating immune responses and immune balance. This ancient language of communication between the nervous and immune systems could potentially be utilized to alleviate inflammation during infection and modulate immune balance in autoimmune diseases.

NEURON (2022)

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Article Multidisciplinary Sciences

CD169+macrophages in lymph node and spleen critically depend on dual RANK and LTbetaR signaling

Abdouramane Camara et al.

Summary: CD169+ macrophages in lymph nodes and spleen require dual signals from LT beta R and RANK for their differentiation. RANKL is necessary for the formation of their niche in lymph nodes, while splenic marginal zone stromal cells provide the source of RANKL for marginal metallophilic macrophage differentiation in the spleen. Loss of these macrophages compromises viral capture and the expansion of virus-specific CD8+ T cells.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

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Article Cell Biology

CXCR3 regulates stem and proliferative CD8+T cells during chronic infection by promoting interactions with DCs in splenic bridging channels

Derek J. Bangs et al.

Summary: Effector CD8+ T cell production during persistent infection requires a stable pool of stem-like cells. Infection models of T cell exhaustion can induce this process through checkpoint blockade, but it occurs spontaneously in mice with chronic Toxoplasma gondii infection. The specific locations of parasite-specific T cell subsets in the spleen imply a connection between differentiation and anatomical niches. Loss of CXCR3 on T cells does not prevent migration but reduces interactions with dendritic cells (DCs) producing CXCR3 ligands and impairs memory-to-intermediate transition, resulting in an accumulation of memory T cells in the spleen. Therefore, CXCR3 increases T cell exposure to differentiation-inducing signals during migration, providing a dynamic mechanism to modulate effector differentiation in response to environmental signals.

CELL REPORTS (2022)

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Article Immunology

A diverse fibroblastic stromal cell landscape in the spleen directs tissue homeostasis and immunity

Yannick O. Alexandre et al.

Summary: This article provides a comprehensive understanding of the cellular and molecular characteristics of fibroblastic stromal cells in the spleen, revealing their significance and diversity in maintaining tissue homeostasis and orchestrating immune responses.

SCIENCE IMMUNOLOGY (2022)

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Review Neurosciences

Neuroimmune Interactions in Peripheral Organs

Roel G. J. Klein Wolterink et al.

Summary: Interactions between the nervous and immune systems are more frequent than previously thought, occurring at different anatomical locations and affecting multiple physiological processes. Understanding these interactions is crucial for exploring therapeutic potential.

ANNUAL REVIEW OF NEUROSCIENCE (2022)

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Article Immunology

Type 1 conventional dendritic cells maintain and guide the differentiation of precursors of exhausted T cells in distinct cellular niches

Sabrina Daehling et al.

Summary: This study identifies the role of conventional dendritic cells 1 (cDC1s) in maintaining and protecting exhausted T cells (Tpex) within specific microenvironments in the spleen. cDC1s prevent overactivation of Tpex cells in other inflammatory environments and balance viral control, exhaustion, and immunopathology.

IMMUNITY (2022)

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Article Immunology

Fate mapping and scRNA sequencing reveal origin and diversity of lymph node stromal precursors

Elisa Lenti et al.

Summary: This study identifies the origin and composition of lymph node stromal and endothelial cells through lineage tracing and single-cell transcriptome analysis. The results show that stromal and endothelial cells originate from different cell populations in the embryo. Single-cell RNA sequencing reveals different subsets of stromal cells and suggests the presence of proliferating progenitors in embryonic lymph nodes.

IMMUNITY (2022)

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Review Immunology

Neural control of immune cell trafficking

Scott N. Mueller

Summary: The communication between the nervous system and the immune system plays a crucial role in both normal physiology and disease. This review explores how neural signals regulate the migration of leukocytes in the body and in tissues, as well as the contributions of different neural signals to an effective immune response. Neural regulation of leukocyte dynamics is influenced by circadian rhythms and can be altered by stress and disease. This review provides an examination of the current understanding of neuro-immune interactions that regulate leukocyte migration and their implications for protective immunity against infections and cancer.

JOURNAL OF EXPERIMENTAL MEDICINE (2022)

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Article Multidisciplinary Sciences

Mapping the developing human immune system across organs

Chenqu Suo et al.

Summary: This study used single-cell genomics to decode the development of the human immune system during prenatal stages, revealing new cell types and the timing of immune function acquisition. The findings have important implications for cell engineering, regenerative medicine, and disease understanding.

SCIENCE (2022)

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Article Multidisciplinary Sciences

MYB orchestrates T cell exhaustion and response to checkpoint inhibition

Carlson Tsui et al.

Summary: This study reveals that CD62L(+) T-PEX cells, maintained by the transcription factor MYB, play a crucial role in maintaining the proliferative potential, multipotency, and repopulation capacity of exhausted T cells during chronic infection, thus contributing to long-term antiviral immunity and responsiveness to immunotherapy.

NATURE (2022)

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Article Immunology

Lymph node homeostasis and adaptation to immune challenge resolved by fibroblast network mechanics

Harry L. Horsnell et al.

Summary: The study examines the mechanics of lymph node swelling during immune response, revealing the role of tissue tension and podoplanin-CLEC-2 signaling in regulating fibroblastic reticular cell proliferation and T cell activation. Molecular signals control the cellular, physical, and structural properties of lymph nodes, which maintain robust tissue architecture in homeostasis but can expand extensively during immune challenge.

NATURE IMMUNOLOGY (2022)

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Article Immunology

Multitier mechanics control stromal adaptations in the swelling lymph node

Frank P. Assen et al.

Summary: Researchers have characterized the biomechanics of lymph node swelling and found that different fibroblast populations mechanically control its expansion in a multitier fashion.

NATURE IMMUNOLOGY (2022)

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Article Neurosciences

Divergent splanchnic sympathetic efferent nerve pathways regulate interleukin-10 and tumour necrosis factor-α responses to endotoxaemia

Michael J. McKinley et al.

Summary: This study investigated the splanchnic sympathetic nerves' role in enhancing interleukin-10 (IL-10) and suppressing tumour necrosis factor-alpha (TNF) levels in the reflex response to systemic immune challenge. The findings demonstrated that the endogenous anti-inflammatory reflex is mediated by sympathetic efferent fibres running in the splanchnic nerves and controlled by divergent pathways for IL-10 and TNF responses, with neurally driven adrenaline regulating IL-10 and sympathetic nerves acting on abdominal organs restraining TNF.

JOURNAL OF PHYSIOLOGY-LONDON (2022)

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Article Multidisciplinary Sciences

The human splenic microcirculation is entirely open as shown by 3D models in virtual reality

Birte S. Steiniger et al.

Summary: The human splenic microcirculation is entirely open, as even the capillary end structures connected with sinuses keep a distance. Follicles are supplied by a dense capillary network primarily from the surrounding red pulp network.

SCIENTIFIC REPORTS (2022)

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Article Biotechnology & Applied Microbiology

Sectm1a Facilitates Protection against Inflammation-Induced Organ Damage through Promoting TRM Self-Renewal

Xingjiang Mu et al.

Summary: Tissue-resident macrophages (TRMs) are crucial for maintaining tissue homeostasis and organ function, with Sectm1a identified as a novel regulator of TRM self-renewal. Sectm1a contributes to stabilizing TRM populations and improving host immune response to acute inflammation, suggesting its potential as a new therapeutic agent for treating inflammatory diseases.

MOLECULAR THERAPY (2021)

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Article Cell Biology

CD112 Regulates Angiogenesis and T Cell Entry into the Spleen

Erica Russo et al.

Summary: Junctional adhesion protein CD112 plays a role in regulating angiogenesis and T cell entry into the spleen in vivo. Its interactions on endothelial cells and leukocytes are crucial for blood vessel coverage and leukocyte transmigration.

CELLS (2021)

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Article Neurosciences

Spleen glia are a transcriptionally unique glial subtype interposed between immune cells and sympathetic axons

Tawaun A. Lucas et al.

Summary: This study focuses on non-myelinating Schwann cells in the spleen, known as spleen glia, which play a role in neuroimmune communication in the spleen. These glial cells express receptors for neurotransmitters and cytokines, potentially participating in communication between nerves and immune cells. Spleen glia are transcriptionally unique compared to other glial types, with genes related to immune responses being differentially expressed.

GLIA (2021)

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Article Immunology

Effector and stem-like memory cell fates are imprinted in distinct lymph node niches directed by CXCR3 ligands

Brigette C. Duckworth et al.

Summary: This study shows that the differentiation fate of T cells is influenced by their location in the lymph node, CXCR3 signaling, and the expression of CXCL9 and CXCL10. Tuning T cell location can promote effector or stem-like memory cell development.

NATURE IMMUNOLOGY (2021)

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Article Immunology

Adrenergic regulation of the vasculature impairs leukocyte interstitial migration and suppresses immune responses

Sapna Devi et al.

Summary: The study demonstrates that adrenergic receptors play a crucial role in modulating leukocyte mobility and immune responses, shedding light on the link between sympathetic nervous system activation and compromised immunity.

IMMUNITY (2021)

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Article Biology

Single-cell transcriptional profiling of splenic fibroblasts reveals subset-specific innate immune signatures in homeostasis and during viral infection

Joern Pezoldt et al.

Summary: This study characterizes the phenotypic and functional heterogeneity of splenic fibroblasts by analyzing over 20,000 single cell transcriptomes, resulting in the identification of 11 distinct clusters or subtypes. The research provides insight into the transcriptional identities of splenic fibroblasts and innate immune signatures of different stromal compartments.

COMMUNICATIONS BIOLOGY (2021)

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Article Multidisciplinary Sciences

Cross-tissue organization of the fibroblast lineage

Matthew B. Buechler et al.

Summary: Recent studies have identified fibroblast heterogeneity in different tissues, and constructed fibroblast atlases based on single-cell transcriptomic data to reveal universal and activated transcriptional subtypes in healthy and diseased states.

NATURE (2021)

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Article Immunology

Gremlin 1+ fibroblastic niche maintains dendritic cell homeostasis in lymphoid tissues

Varun N. Kapoor et al.

Summary: Fibroblastic reticular cells, specifically the Grem1(+) subset, play a crucial role in supporting T cell immunity and maintaining the homeostasis of tissue-resident cDCs in lymph nodes. Single-cell RNA sequencing analyses in both human and mouse lymph nodes reveal the significance of Grem1(+) FRCs in regulating lymphocyte compartmentalization and innate and adaptive immunity.

NATURE IMMUNOLOGY (2021)

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Article Immunology

Follicular lymphoma triggers phenotypic and functional remodeling of the human lymphoid stromal cell landscape

Frederic Mourcin et al.

Summary: The study identified three distinct human lymphoid stromal cell (LSC) subsets with different functions in healthy tissue. In lymphoma, LSCs can be reprogrammed in response to cytokines like tumor necrosis factor and transforming growth factor beta, leading to increased expression of chemokines. This bidirectional crosstalk between LSCs and malignant B cells may be a targetable axis in lymphoma.

IMMUNITY (2021)

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Article Cell Biology

Fibroblastic reticular cell response to dendritic cells requires coordinated activity of podoplanin, CD44 and CD9

Charlotte M. de Winde et al.

Summary: In adaptive immunity, CLEC-2(+) dendritic cells inhibit podoplanin-dependent actomyosin contractility in fibroblastic reticular cells (FRCs) to allow FRC spreading and lymph node expansion. Podoplanin and its partner proteins CD44 and CD9 are differentially expressed by specific lymph node stromal populations in vivo, and their expression in FRCs is coregulated by CLEC-2. Both CD44 and CD9 suppress podoplanin-dependent contractility and play crucial roles in FRC polarity, alignment, and interactions.

JOURNAL OF CELL SCIENCE (2021)

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Article Cell Biology

Expression of ACKR4 demarcates the peri-marginal sinus,'' a specialized vascular compartment of the splenic red pulp

Kathrin Werth et al.

Summary: A study identifies a vascular compartment within the spleen, delineated by endothelial cells expressing ACKR4, which supports the homing of T cells into the spleen.

CELL REPORTS (2021)

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Article Biochemistry & Molecular Biology

Single-Cell Transcriptome Atlas of Murine Endothelial Cells

Joanna Kalucka et al.

CELL (2020)

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Article Immunology

IL-7 derived from lymph node fibroblastic reticular cells is dispensable for naive T cell homeostasis but crucial for central memory T cell survival

Laura Knop et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2020)

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Article Cell Biology

The lymph node at a glance - how spatial organization optimizes the immune response

Spencer M. Grant et al.

JOURNAL OF CELL SCIENCE (2020)

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Article Multidisciplinary Sciences

PD-1+stemlike CD8 T cells are resident in lymphoid tissues during persistent LCMV infection

Se Jin Im et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Immunology

Visualization of T Cell Migration in the Spleen Reveals a Network of Perivascular Pathways that Guide Entry into T Zones

Anne Chauveau et al.

IMMUNITY (2020)

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Review Parasitology

The Human Spleen in Malaria: Filter or Shelter?

Benoit Henry et al.

TRENDS IN PARASITOLOGY (2020)

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Article Multidisciplinary Sciences

Brain control of humoral immune responses amenable to behavioural modulation

Xu Zhang et al.

NATURE (2020)

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Article Immunology

Remodeling of light and dark zone follicular dendritic cells governs germinal center responses

Natalia B. Pikor et al.

NATURE IMMUNOLOGY (2020)

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Article Immunology

Reticular Fibroblasts Expressing the Transcription Factor WT1 Define a Stromal Niche that Maintains and Replenishes Splenic Red Pulp Macrophages

Alicia Bellomo et al.

IMMUNITY (2020)

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Article Multidisciplinary Sciences

Microbiota modulate sympathetic neurons via a gut-brain circuit

Paul A. Muller et al.

NATURE (2020)

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Review Immunology

Neuropeptide Y Is an Immunomodulatory Factor: Direct and Indirect

Wei-can Chen et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Immunology

Type I interferon signaling in fibroblastic reticular cells prevents exhaustive activation of antiviral CD8+ T cells

Christian Perez-Shibayama et al.

SCIENCE IMMUNOLOGY (2020)

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Article Multidisciplinary Sciences

Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp

Hung-Wei Cheng et al.

NATURE COMMUNICATIONS (2019)

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Article Cell Biology

Panicle-Shaped Sympathetic Architecture in the Spleen Parenchyma Modulates Antibacterial Innate Immunity

Xiaofan Ding et al.

CELL REPORTS (2019)

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Article Immunology

Functional circuitry of neuro-immune communication in the mesenteric lymph node and spleen

Kaitlin Murray et al.

BRAIN BEHAVIOR AND IMMUNITY (2019)

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Article Immunology

TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision

Zeyu Chen et al.

IMMUNITY (2019)

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Article Physiology

Anti-inflammatory reflex action of splanchnic sympathetic nerves is distributed across abdominal organs

Davide Martelli et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2019)

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Article Immunology

Defining 'T cell exhaustion'

Christian U. Blank et al.

NATURE REVIEWS IMMUNOLOGY (2019)

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Review Immunology

Dendritic cell subsets in T cell programming: location dictates function

S. C. Eisenbarth

NATURE REVIEWS IMMUNOLOGY (2019)

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Article Immunology

Clever-1 contributes to lymphocyte entry into the spleen via the red pulp

Sina Tadayon et al.

SCIENCE IMMUNOLOGY (2019)

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Article Biochemistry & Molecular Biology

Physiological and Genetic Adaptations to Diving in Sea Nomads

Melissa A. Ilardo et al.

CELL (2018)

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Article Immunology

Glucocorticoids Drive Diurnal Oscillations in T Cell Distribution and Responses by Inducing Interleukin-7 Receptor and CXCR4

Akihiro Shimba et al.

IMMUNITY (2018)

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Article Immunology

Single-Cell RNA Sequencing of Lymph Node Stromal Cells Reveals Niche-Associated Heterogeneity

Lauren B. Rodda et al.

IMMUNITY (2018)

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Article Immunology

Essential Role of Canonical NF-kappa B Activity in the Development of Stromal Cell Subsets in Secondary Lymphoid Organs

Dana Bogdanova et al.

JOURNAL OF IMMUNOLOGY (2018)

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Article Medicine, Research & Experimental

Human immunodeficiency virus infection induces lymphoid fibrosis in the BM-liver-thymus-spleen humanized mouse mode

Jasmine Samal et al.

JCI INSIGHT (2018)

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Article Cell Biology

Infection Programs Sustained Lymphoid Stromal Cell Responses and Shapes Lymph Node Remodeling upon Secondary Challenge

Julia L. Gregory et al.

CELL REPORTS (2017)

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Article Cell Biology

Perivascular Fibroblasts of the Developing Spleen Act as LTα1β2-Dependent Precursors of Both T and B Zone Organizer Cells

Karin Schaeuble et al.

CELL REPORTS (2017)

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Article Multidisciplinary Sciences

Neuroanatomy of the spleen: Mapping the relationship between sympathetic neurons and lymphocytes

Kaitlin Murray et al.

PLOS ONE (2017)

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Review Immunology

Adult haematopoietic stem cell niches

Genevieve M. Crane et al.

NATURE REVIEWS IMMUNOLOGY (2017)

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Article Immunology

Distinct oxysterol requirements for positioning naive and activated dendritic cells in the spleen

Erick Lu et al.

SCIENCE IMMUNOLOGY (2017)

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Article Immunology

XCR1+ dendritic cells promote memory CD8+ T cell recall upon secondary infections with Listeria monocytogenes or certain viruses

Yannick O. Alexandre et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2016)

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Article Immunology

T Cell Factor 1-Expressing Memory-like CD8+ T Cells Sustain the Immune Response to Chronic Viral Infections

Daniel T. Utzschneider et al.

IMMUNITY (2016)

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Article Immunology

Disorganization of the splenic microanatomy in ageing mice

Danielle Aw et al.

IMMUNOLOGY (2016)

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Article Medicine, Research & Experimental

Transcription factor TLX1 controls retinoic acid signaling to ensure spleen development

Elisa Lenti et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

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Article Immunology

Adrenergic control of the adaptive immune response by diurnal lymphocyte recirculation through lymph nodes

Kazuhiro Suzuki et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2016)

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Article Multidisciplinary Sciences

Follicular CXCR5-expressing CD8+ T cells curtail chronic viral infection

Ran He et al.

NATURE (2016)

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Article Multidisciplinary Sciences

Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

Se Jin Im et al.

NATURE (2016)

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Article Immunology

CXCR5+ follicular cytotoxic T cells control viral infection in B cell follicles

Yew Ann Leong et al.

NATURE IMMUNOLOGY (2016)

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Article Multidisciplinary Sciences

CCR7 expression alters memory CD8 T-cell homeostasis by regulating occupancy in IL-7-and IL-15-dependent niches

Yong Woo Jung et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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Article Multidisciplinary Sciences

Biomechanics of red blood cells in human spleen and consequences for physiology and disease

Igor V. Pivkin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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Article Cell Biology

Context-Dependent Development of Lymphoid Stroma from Adult CD34+ Adventitial Progenitors

Katarzyna M. Sitnik et al.

CELL REPORTS (2016)

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Article Cell Biology

Differential Intrasplenic Migration of Dendritic Cell Subsets Tailors Adaptive Immunity

Samuele Calabro et al.

CELL REPORTS (2016)

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Review Immunology

Human spleen microanatomy: why mice do not suffice

Birte S. Steiniger

IMMUNOLOGY (2015)

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Article Immunology

CD8 T Cells Enter the Splenic T Cell Zones Independently of CCR7, but the Subsequent Expansion and Trafficking Patterns of Effector T Cells after Infection Are Dysregulated in the Absence of CCR7 Migratory Cues

Naveen Sharma et al.

JOURNAL OF IMMUNOLOGY (2015)

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Article Immunology

Phenotypic and Morphological Properties of Germinal Center Dark Zone Cxcl12-Expressing Reticular Cells

Lauren B. Rodda et al.

JOURNAL OF IMMUNOLOGY (2015)

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Article Multidisciplinary Sciences

A perisinusoidal niche for extramedullary haematopoiesis in the spleen

Christopher N. Inra et al.

NATURE (2015)

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Article Multidisciplinary Sciences

Infection with Salmonella enterica Serovar Typhimurium Leads to Increased Proportions of F4/80+ Red Pulp Macrophages and Decreased Proportions of B and T Lymphocytes in the Spleen

Kristin L. Rosche et al.

PLOS ONE (2015)

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Article Microbiology

Natural Killer Cell Sensing of Infected Cells Compensates for MyD88 Deficiency but Not IFN-I Activity in Resistance to Mouse Cytomegalovirus

Clement Cocita et al.

PLOS PATHOGENS (2015)

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Article Cardiac & Cardiovascular Systems

Essential role for TMEM100 in vascular integrity but limited contributions to the pathogenesis of hereditary haemorrhagic telangiectasia

Eun-Hye Moon et al.

CARDIOVASCULAR RESEARCH (2015)

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Article Cell Biology

B lymphocyte compartments in the human splenic red pulp: capillary sheaths and periarteriolar regions

Birte S. Steiniger et al.

HISTOCHEMISTRY AND CELL BIOLOGY (2014)

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Article Immunology

Heterogeneity of stromal cells in the human splenic white pulp. Fibroblastic reticulum cells, follicular dendritic cells and a third superficial stromal cell type

Birte S. Steiniger et al.

IMMUNOLOGY (2014)

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Article Immunology

Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses

Nicolas Fasnacht et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2014)

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Article Immunology

Innate lymphoid cells integrate stromal and immunological signals to enhance antibody production by splenic marginal zone B cells

Giuliana Magri et al.

NATURE IMMUNOLOGY (2014)

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Article Multidisciplinary Sciences

Characterization of the IL-15 niche in primary and secondary lymphoid organs in vivo

Guangwei Cui et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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Review Immunology

Memory T Cell Subsets, Migration Patterns, and Tissue Residence

Scott N. Mueller et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 31 (2013)

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Article Immunology

Germinal Center Centroblasts Transition to a Centrocyte Phenotype According to a Timed Program and Depend on the Dark Zone for Effective Selection

Oliver Bannard et al.

IMMUNITY (2013)

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Article Immunology

Maturation of Lymph Node Fibroblastic Reticular Cells from Myofibroblastic Precursors Is Critical for Antiviral Immunity

Qian Chai et al.

IMMUNITY (2013)

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Article Immunology

Chronic but Not Acute Virus Infection Induces Sustained Expansion of Myeloid Suppressor Cell Numbers that Inhibit Viral-Specific T Cell Immunity

Brian A. Norris et al.

IMMUNITY (2013)

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Review Immunology

Pathobiology of HIV/SIV-associated changes in secondary lymphoid tissues

Jacob D. Estes

IMMUNOLOGICAL REVIEWS (2013)

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Article Immunology

Transcriptional Regulation of IL-15 Expression during Hematopoiesis

Sara L. Colpitts et al.

JOURNAL OF IMMUNOLOGY (2013)

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Article Multidisciplinary Sciences

Visualization of splenic marginal zone B-cell shuttling and follicular B-cell egress

Tal I. Arnon et al.

NATURE (2013)

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Article Multidisciplinary Sciences

Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2

Brett H. Herzog et al.

NATURE (2013)

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Article Biochemistry & Molecular Biology

Follicular Dendritic Cells Emerge from Ubiquitous Perivascular Precursors

Nike Julia Krautler et al.

CELL (2012)

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Article Physiology

Neural regulation of inflammation: no neural connection from the vagus to splenic sympathetic neurons

B. O. Bratton et al.

EXPERIMENTAL PHYSIOLOGY (2012)

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Article Immunology

Adrenergic Nerves Govern Circadian Leukocyte Recruitment to Tissues

Christoph Scheiermann et al.

IMMUNITY (2012)

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Article Immunology

Podoplanin-Rich Stromal Networks Induce Dendritic Cell Motility via Activation of the C-type Lectin Receptor CLEC-2

Sophie E. Acton et al.

IMMUNITY (2012)

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Article Immunology

B cell-helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen

Irene Puga et al.

NATURE IMMUNOLOGY (2012)

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Article Multidisciplinary Sciences

The Alarmin Interleukin-33 Drives Protective Antiviral CD8+ T Cell Responses

Weldy V. Bonilla et al.

SCIENCE (2012)

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Article Cell Biology

Immune Tolerance to Tumor Antigens Occurs in a Specialized Environment of the Spleen

Stefano Ugel et al.

CELL REPORTS (2012)

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Review Immunology

Podoplanin: emerging functions in development the immune system and cancer

Jillian L. Astarita et al.

FRONTIERS IN IMMUNOLOGY (2012)

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Review Cell Biology

Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises

Annika Armulik et al.

DEVELOPMENTAL CELL (2011)

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Article Cell Biology

The follicular dendritic cell network in secondary follicles of human palatine tonsils and spleens

Birte Steiniger et al.

HISTOCHEMISTRY AND CELL BIOLOGY (2011)

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Article Medicine, Research & Experimental

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