期刊
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
卷 30, 期 22, 页码 61965-61976出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s11356-023-26475-7
关键词
Binucleate cell; Cell abnormalities; Pharmacological compounds; Mitotic inhibition; Micronuclei
The possible cytotoxic effects of paracetamol were evaluated using two bioindicator plants Lens culinaris and Pisum sativum. The results showed that paracetamol inhibited root growth, caused abnormalities, and significant micronucleus formation in both plants, indicating a high degree of toxicity.
Paracetamol is one of the most widely used drugs worldwide, yet its environmental presence and hazardous impact on non-target organisms could rapidly increase. In this study, the possible cytotoxic effects of paracetamol were evaluated using two bioindicator plants Lens culinaris and Pisum sativum. Concentrations of 500, 400, 300, 200, 100, 50, 25, 5, 1 mg L-1, and a control (distilled water) were used for a total of 10 treatments, which were subsequently applied on seeds of Lens culinaris Med. and Pisum sativum L.; after 72 h of exposure, root growth, mitotic index, percentage of chromosomal abnormalities, and the presence of micronucleus were evaluated. The cytotoxic effect of paracetamol on L. culinaris and P. sativum was demonstrated, reporting the inhibition of root growth, the presence of abnormalities, and a significant micronucleus index at all concentrations used, which shows that this drug has a high degree of toxicity.
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