Application of nanomaterials in the treatment of intracerebral hemorrhage

Intracerebral hemorrhage (ICH) is a non-traumatic hemorrhage caused by the rupture of blood vessels in the brain parenchyma, with an acute mortality rate of 30%-40%. Currently, available treatment options that include surgery are not promising, and new approaches are urgently needed. Nanotechnology offers new prospects in ICH because of its unique benefits. In this review, we summarize the applications of various nanomaterials in ICH. Nanomaterials not only enhance the therapeutic effects of drugs as delivery carriers but also contribute to several facets after ICH such as repressing detrimental neuroinflammation, resisting oxidative stress, reducing cell death, and improving functional deficits.

Automated summary

Intracerebral hemorrhage (ICH) is a non-traumatic hemorrhage caused by blood vessel rupture in the brain parenchyma, with a high mortality rate. Nanotechnology provides new prospects in ICH treatment by enhancing drug therapy and improving post-ICH outcomes such as neuroinflammation suppression, oxidative stress resistance, cell death reduction, and functional deficits improvement.