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Vitamin D in hypoparathyroidism: insight into pathophysiology and perspectives in clinical practice

ENDOCRINE (2023)

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Article Endocrinology & Metabolism

The Clinical and Skeletal Effects of Long-Term Therapy of Hypoparathyroidism With rhPTH(1-84)

Sanchita Agarwal et al.

Summary: Hypoparathyroidism is a disorder characterized by low calcium levels, reduced parathyroid hormone, decreased bone remodeling, and increased bone density. Long-term treatment with PTH can reduce the need for calcium and active vitamin D supplements, maintain normal calcium levels, but lead to a decrease in bone mass.

JOURNAL OF BONE AND MINERAL RESEARCH (2023)

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Article Nutrition & Dietetics

Genomic or Non-Genomic? A Question about the Pleiotropic Roles of Vitamin D in Inflammatory-Based Diseases

Michael F. Holick et al.

Nutrients (2023)

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Article Endocrinology & Metabolism

Efficacy and Safety of Parathyroid Hormone Replacement With TransCon PTH in Hypoparathyroidism: 26-Week Results From the Phase 3 PaTHway Trial

Aliya A. Khan et al.

Summary: TransCon PTH demonstrated efficacy in maintaining normocalcemia and allowing independence from conventional therapy in individuals with hypoparathyroidism. The treatment also showed significant improvements in health-related quality of life and hypoparathyroidism-related symptoms.

JOURNAL OF BONE AND MINERAL RESEARCH (2023)

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Article Endocrinology & Metabolism

Renal complications and quality of life in postsurgical hypoparathyroidism: a case-control study

L. Mazoni et al.

Summary: The study found that patients with chronic post-operative HypoPT had a higher rate of renal calcifications compared to those without the condition. Additionally, they exhibited reduced quality of life and around half of the patients reported symptoms of hypocalcemia, highlighting the suboptimal effectiveness of conventional therapy.

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION (2022)

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Article Endocrinology & Metabolism

Calcium Citrate Versus Calcium Carbonate in the Management of Chronic Hypoparathyroidism: A Randomized, Double-Blind, Crossover Clinical Trial

Anda Mihaela Naciu et al.

Summary: This study evaluated the therapeutic advantage of calcium citrate (Ca-Cit) compared to calcium carbonate (CaCO3) in hypoparathyroidism, and found that Ca-Cit may have a potential beneficial effect on reducing the risk of nephrolithiasis. Additionally, Ca-Cit was associated with less constipation symptoms compared to CaCO3.

JOURNAL OF BONE AND MINERAL RESEARCH (2022)

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Article Endocrinology & Metabolism

Multicenter retro-prospective observational study on chronic hypoparathyroidism and rhPTH (1-84) treatment

G. Marcucci et al.

Summary: This study investigates the effects of 12 months of rhPTH (1-84) treatment in patients with hypoparathyroidism. The results show that rhPTH (1-84) therapy is both safe and effective.

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION (2022)

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Review Nutrition & Dietetics

Interaction of Vitamin D with Peptide Hormones with Emphasis on Parathyroid Hormone, FGF23, and the Renin-Angiotensin-Aldosterone System

Nejla Latic et al.

Summary: PTH and FGF23 are major regulators of vitamin D metabolism. Their interaction in the kidney is crucial for maintaining mineral balance. 1,25(OH)(2)D is a key molecule in this system, regulated by FGF23 and PTH. Recent studies have also indicated an important role of vitamin D signaling in cardiovascular health.

NUTRIENTS (2022)

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Review Endocrinology & Metabolism

Complications, Symptoms, Presurgical Predictors in Patients With Chronic Hypoparathyroidism: A Systematic Review

Liang Yao et al.

Summary: This study aimed to identify symptoms and complications associated with chronic hypoparathyroidism and evaluate the predictive value of early postoperative measurements of PTH and calcium. The results revealed nine common complications and symptoms likely associated with chronic hypoparathyroidism. PTH values above 10 pg/mL 12-24 hours after surgery were strong predictors of no chronic hypoparathyroidism development, while patients with PTH values below the threshold required careful monitoring.

JOURNAL OF BONE AND MINERAL RESEARCH (2022)

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Article Endocrinology & Metabolism

Epidemiology and Financial Burden of Adult Chronic Hypoparathyroidism

Sigridur Bjornsdottir et al.

Summary: Chronic hypoparathyroidism is a rare disorder characterized by low serum calcium, increased serum phosphorus, and decreased parathyroid hormone. The epidemiology and complications of this disorder are not well understood, but it is associated with significant morbidity and a substantial financial burden.

JOURNAL OF BONE AND MINERAL RESEARCH (2022)

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Article Biochemistry & Molecular Biology

Parameters of Vitamin D Metabolism in Patients with Hypoparathyroidism

Artem Zhukov et al.

Summary: This study evaluated the extended spectrum of vitamin D metabolites in patients with HypoPT compared to healthy individuals. The results showed that patients with HypoPT achieved an adequate level of 25(OH)D-3 with standard doses of cholecalciferol, but they had supraphysiological levels of 1,25(OH)(2)D-3 and increased production of inactive metabolite. The abnormality of vitamin D metabolism does not seem to interfere with the achievement of hypoparathyroidism compensation.

METABOLITES (2022)

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Article Endocrinology & Metabolism

Serum calcium levels are associated with cognitive function in hypoparathyroidism: a neuropsychological and biochemical study in an Italian cohort of patients with chronic post-surgical hypoparathyroidism

F. Saponaro et al.

Summary: This study evaluated cognitive functions in patients with chronic post-surgical hypoparathyroidism and found that low serum calcium levels are associated with a decline in semantic memory abilities and executive function.

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION (2022)

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Article Endocrinology & Metabolism

Management of Hypoparathyroidism

Aliya A. Khan et al.

Summary: Hypoparathyroidism is a rare disorder characterized by low calcium levels due to decreased parathyroid hormone. Neck surgery is the most common cause. Conventional therapy includes calcium and vitamin D analogues, but it has limitations. Parathyroid hormone replacement therapy may be beneficial for unsatisfactory cases.

JOURNAL OF BONE AND MINERAL RESEARCH (2022)

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Article Endocrinology & Metabolism

Evaluation and Management of Hypoparathyroidism Summary Statement and Guidelines from the Second International Workshop

Aliya A. Khan et al.

Summary: This clinical practice guideline provides evidence-based recommendations for the prevention, diagnosis, and management of hypoparathyroidism. Evaluating serum PTH within 12 to 24 hours post total thyroidectomy can predict the development of permanent postsurgical hypoparathyroidism. Genetic testing may be helpful for individuals with nonsurgical hypoparathyroidism.

JOURNAL OF BONE AND MINERAL RESEARCH (2022)

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Review Endocrinology & Metabolism

Etiology and Pathophysiology of Hypoparathyroidism: A Narrative Review

Janice L. Pasieka et al.

Summary: This article utilized a systematic review to investigate the etiologies and pathogenesis of hypoparathyroidism, with a particular focus on new knowledge about parathyroid gland viability and intraoperative parathyroid hormone monitoring. Non-surgical factors, especially genetic factors, play a significant role in hypoparathyroidism. Due to the widespread impact of PTH deficiency on multiple organ systems, the article provides a detailed review of skeletal, renal, neuromuscular, and ocular complications. The burden of illness on patients and their caregivers leads to reduced quality of life and increased social costs for this chronic endocrinopathy.

JOURNAL OF BONE AND MINERAL RESEARCH (2022)

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Article Endocrinology & Metabolism

Hypoparathyroidism: update of guidelines from the 2022 International Task Force

Bart L. Clarke

Summary: The 2022 International Task Force guidelines for chronic hypoparathyroidism will be published soon, updating the original guidelines from 2016 with new information. Chronic postsurgical hypoparathyroidism is now defined as lasting for at least 12 months after surgery. Serum PTH <10 pg/mL in the first 12-24 hours after surgery may predict chronic postsurgical hypoparathyroidism. The guidelines also provide detailed information on the symptoms, complications, monitoring, and management of chronic hypoparathyroidism for the next five years.

ARCHIVES OF ENDOCRINOLOGY METABOLISM (2022)

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Article Multidisciplinary Sciences

Generation of novel genetically modified rats to reveal the molecular mechanisms of vitamin D actions

Miyu Nishikawa et al.

SCIENTIFIC REPORTS (2020)

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Article Endocrinology & Metabolism

The relative influence of serum ionized calcium and 25-hydroxyvitamin D in regulating PTH secretion in healthy subjects

Federica Ferrone et al.

BONE (2019)

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Review Endocrinology & Metabolism

Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions

Roger Bouillon et al.

ENDOCRINE REVIEWS (2019)

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Article Endocrinology & Metabolism

HypoparaNet: A Database of Chronic Hypoparathyroidism Based on Expert Medical-Surgical Centers in Italy

Gemma Marcucci et al.

CALCIFIED TISSUE INTERNATIONAL (2018)

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Article Endocrinology & Metabolism

Efficacy and safety of long-term management of patients with chronic post-surgical hypoparathyroidism

A. Meola et al.

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION (2018)

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Article Endocrinology & Metabolism

Vertebral Fractures and Bone Mineral Density in Patients With Idiopathic Hypoparathyroidism on Long-Term Follow-Up

Himika Chawla et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2017)

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Article Endocrinology & Metabolism

Hypoparathyroidism: Less Severe Hypocalcemia With Treatment With Vitamin D2 Compared With Calcitriol

Elizabeth A. Streeten et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2017)

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Article Multidisciplinary Sciences

25-Hydroxyvitamin D3 induces osteogenic differentiation of human mesenchymal stem cells

Yan-Ru Lou et al.

SCIENTIFIC REPORTS (2017)

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Article Endocrinology & Metabolism

Effects of parathyroid hormone rhPTH(1-84) on phosphate homeostasis and vitamin D metabolism in hypoparathyroidism: REPLACE phase 3 study

Bart L. Clarke et al.

ENDOCRINE (2017)

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Article Endocrinology & Metabolism

Noninvasive Assessment of Skeletal Microstructure and Estimated Bone Strength in Hypoparathyroidism

Natalie E. Cusano et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2016)

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Article Endocrinology & Metabolism

Management of Hypoparathyroidism: Summary Statement and Guidelines

Maria Luisa Brandi et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2016)

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Article Endocrinology & Metabolism

European Society of Endocrinology Clinical Guideline: Treatment of chronic hypoparathyroidism in adults

Jens Bollerslev et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2015)

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Article Endocrinology & Metabolism

PTH(1-34) for Surgical Hypoparathyroidism: A Prospective, Open-Label Investigation of Efficacy and Quality of Life

Assunta Santonati et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2015)

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Article Endocrinology & Metabolism

The clinical use of vitamin D metabolites and their potential developments: a position statement from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) and the International Osteoporosis Foundation (IOF)

Luisella Cianferotti et al.

ENDOCRINE (2015)

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Review Biochemistry & Molecular Biology

Vitamin D and DBP: The free hormone hypothesis revisited

Rene F. Chun et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2014)

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Article Endocrinology & Metabolism

Increased vertebral morphometric fracture in patients with postsurgical hypoparathyroidism despite normal bone mineral density

Maira L. Mendonca et al.

BMC ENDOCRINE DISORDERS (2013)

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Article Endocrinology & Metabolism

Short-Term Effects on Bone Turnover Markers of a Single High Dose of Oral Vitamin D3

Maurizio Rossini et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2012)

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Article Endocrinology & Metabolism

Long-Term Follow-Up of Patients with Hypoparathyroidism

Deborah M. Mitchell et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2012)

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Article Endocrinology & Metabolism

PTH(1-84) Administration Reverses Abnormal Bone-Remodeling Dynamics and Structure in Hypoparathyroidism

Mishaela R. Rubin et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2011)

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Article Endocrinology & Metabolism

Effect of a Single Oral Dose of 600,000 IU of Cholecalciferol on Serum Calciotropic Hormones in Young Subjects with Vitamin D Deficiency: A Prospective Intervention Study

Cristiana Cipriani et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2010)

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Article Biochemistry & Molecular Biology

25-Hydroxyvitamin D3 is an agonistic vitamin D receptor ligand

Yan-Ru Lou et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2010)

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Article Endocrinology & Metabolism

Dynamic and Structural Properties of the Skeleton in Hypoparathyroidism

Mishaela R. Rubin et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2008)

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Article Biochemistry & Molecular Biology

25-hydroxyvitamin D-3 is an active hormone in human primary prostatic stromal cells

YR Lou et al.

FASEB JOURNAL (2003)

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