Treatment of Alzheimer's disease with small-molecule photosensitizers

Alzheimer's disease is a neurodegenerative disease that signals for excess ,B-amyloid (A ,B) aggregation. Although people have made great attempts to control the aggregation of A ,B, no effective medications have been produced yet. Due to its excellent temporal and spatial selectivity, photodynamic treatment has been gradually employed and interfered in the aggregation process of A ,B, with some achievement. To enhance the research and application of photodynamic therapy in Alzheimer's disease, this paper reviews the progress of small-molecule photosensitizers in the treatment of Alzheimer's disease in recent years and outlines existing tactics and potential obstacles. (c) 2023 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.

Automated summary

Alzheimer's disease is a neurodegenerative disease characterized by the aggregation of β-amyloid (A,B). Although efforts have been made to control A,B aggregation, no effective medications have been developed. Photodynamic treatment, due to its excellent temporal and spatial selectivity, has been employed to intervene in the aggregation process with some success. This paper reviews the progress of small-molecule photosensitizers in recent years and outlines existing strategies and potential obstacles for enhancing the research and application of photodynamic therapy in Alzheimer's disease.