4.5 Article

Cerebral abscesses with odontogenic origin: a population-based cohort study

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CLINICAL ORAL INVESTIGATIONS
卷 27, 期 7, 页码 3639-3648

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SPRINGER HEIDELBERG
DOI: 10.1007/s00784-023-04976-6

关键词

Brain abscess; Dental infection control; Microbiology; Oral health; Oral pathology; Panoramic radiography

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Recent studies have shown an increase in cerebral abscess (CA) patients with odontogenic origin. However, these patients are often poorly characterized and the cause is unknown. This study aims to identify and characterize CA patients with odontogenic origin based on microbiologic, radiographic, and/or clinical findings.
ObjectivesRecent studies have indicated that cerebral abscess (CA) patients with odontogenic origin are on the rise. However, CA patients are often poorly characterized and with an unknown etiologic background. The purpose of this study is to identify and characterize CA patients that may have an odontogenic origin based on microbiologic, radiographic, and/or clinical findings.Materials and methodsThis is a population-based cohort study analyzing retrospective and prospective data from CA patients. Radiographic examinations of panoramic radiographs (PRs) or computed tomography (CT) scans were conducted. CA patients characterized with odontogenic origin required the fulfilment of the following criteria on admission: (1) Oral pathologic conditions were the only bacterial infections present, (2) oral microorganisms were isolated in the purulent exudate from the brain, and (3) radiographically and/or clinical recordings of oral pathologic conditions.ResultsA total of 44 patients could be included in this study of which 25 (57%) were characterized as having CA with a likely odontogenic origin. Type two diabetes (T2D) (p = 0.014) and microorganisms of the Streptococcus anginosus group (SAG) (p < 0.01) were overrepresented in patients with CAs of odontogenic origin.ConclusionsOdontogenic infections may cause CAs to a greater extent than previously assumed. T2D was overrepresented among patients with odontogenic CA. When microorganisms of the SAG were isolated from the brain pus, CA patients had a predisposing odontogenic or sinus infection.

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