4.7 Article

Probing lipids relaxation times in breast cancer using magnetic resonance spectroscopic fingerprinting

期刊

EUROPEAN RADIOLOGY
卷 -, 期 -, 页码 -

出版社

SPRINGER
DOI: 10.1007/s00330-023-09560-w

关键词

Breast MRS; Magnetic resonance spectroscopy; Magnetic resonance fingerprinting; Breast cancer imaging; Lipids in breast cancer

向作者/读者索取更多资源

This study investigated the clinical relevance of the relaxation times of lipids within breast cancer and normal fibroglandular tissue using magnetic resonance spectroscopic fingerprinting (MRSF). The results showed significant differences in the relaxation times of certain lipids between breast cancer patients and healthy controls. The study demonstrates the feasibility and clinical applicability of using MRSF for breast cancer imaging.
ObjectivesTo investigate the clinical relevance of the relaxation times of lipids within breast cancer and normal fibroglandular tissue in vivo, using magnetic resonance spectroscopic fingerprinting (MRSF).MethodsTwelve patients with biopsy-confirmed breast cancer and 14 healthy controls were prospectively scanned at 3 T using a protocol consisting of diffusion tensor imaging (DTI), MRSF, and dynamic contrast-enhanced (DCE) MRI. Single-voxel MRSF data was recorded from the tumor (patients) - identified using DTI - or normal fibroglandular tissue (controls), in under 20 s. MRSF data was analyzed using in-house software. Linear mixed model analysis was used to compare the relaxation times of lipids in breast cancer VOIs vs. normal fibroglandular tissue.ResultsSeven distinguished lipid metabolite peaks were identified and their relaxation times were recorded. Of them, several exhibited statistically significant changes between controls and patients, with strong significance (p < 10(-3)) recorded for several of the lipid resonances at 1.3 ppm (T-1 = 355 +/- 17 ms vs. 389 +/- 27 ms), 4.1 ppm (T-1 = 255 +/- 86 ms vs. 127 +/- 33 ms), 5.22 ppm (T-1 = 724 +/- 81 ms vs. 516 +/- 62 ms), and 5.31 ppm (T-2 = 56 +/- 5 ms vs. 44 +/- 3.5 ms, respectively).ConclusionsThe application of MRSF to breast cancer imaging is feasible and achievable in clinically relevant scan time. Further studies are required to verify and comprehend the underling biological mechanism behind the differences in lipid relaxation times in cancer and normal fibroglandular tissue.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据