4.8 Article

Discovery of a photoactivatable dimerized STING agonist based on the benzo[b]selenophene scaffold

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Medicinal

Development of Potent Immune Modulators Targeting Stimulator of Interferon Genes Receptor

Min Jae Jeon et al.

Summary: Stimulator of interferon genes (STING) is an endoplasmic reticulum membrane protein that plays important roles in cancer immunotherapy. Researchers have synthesized and characterized STING modulators that stimulate downstream signaling and promote immune responses, suggesting their therapeutic potential for cancer treatment.

JOURNAL OF MEDICINAL CHEMISTRY (2022)

Article Chemistry, Medicinal

Incorporating Selenium into Heterocycles and NaturalProducts-From Chemical Properties to Pharmacological Activities

Wei Hou et al.

Summary: This article summarizes and discusses the relationship between the pharmacological activities and chemical properties of selenium compounds and the strategic incorporation of selenium into organic molecules, as well as provides perspectives on future research directions.

JOURNAL OF MEDICINAL CHEMISTRY (2022)

Article Chemistry, Medicinal

Structure-Activity relationship study of benzothiophene oxobutanoic acid analogues leading to novel stimulator of interferon gene (STING) agonists

Ancheng Shen et al.

Summary: This study identified a series of N-substituted acyloxyamino derivatives as potent STING agonists based on the structure-activity relationship study of MSA-2. Compound 57 showed the most potent activity against both h-STING and m-STING, and demonstrated significant anti-tumor efficacy in mouse tumor models, as well as induction of immune memory.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)

Review Pharmacology & Pharmacy

Targeting drug delivery with light: A highly focused approach

Teresa L. Rapp et al.

Summary: This article discusses the unique power of light as a tool for controlling molecular events in biology and highlights recent innovations in photosensitive drug delivery. It also points out future opportunities to engineer and exploit light-responsive technologies in the clinical setting.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Article Chemistry, Medicinal

Structure-Activity Relationship Study of Amidobenzimidazole Analogues Leading to Potent and Systemically Administrable Stimulator of Interferon Gene (STING) Agonists

Zilan Song et al.

Summary: The development of a new STING agonist triazole 40 has shown significant anti-tumor efficacy in vivo, with good tolerance in two mouse tumor models.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

Review Cell Biology

Benefits of Zebrafish Xenograft Models in Cancer Research

Xingyu Chen et al.

Summary: Zebrafish are widely used in cancer research due to their low cost, quick establishment, and small sample size required. The zebrafish patient-derived xenograft (zPDX) models show promising evidence for short-term clinical treatment.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Chemistry, Medicinal

Design, Synthesis, and Biological Evaluation of a Novel Photocaged PI3K Inhibitor toward Precise Cancer Treatment

Kehui Zhang et al.

Summary: A novel photocaged PI3K inhibitor 1 was designed and synthesized, which could release a highly effective PI3K inhibitor 2 upon UV irradiation, showing significantly enhanced antiproliferative activity against multiple cancer cell lines and favorable anticancer activity in patient-derived tumor organoid and zebrafish xenograft models, indicating its potential for precise cancer treatment.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

Review Oncology

Selenium stimulates the antitumour immunity: Insights to future research

Ali Razaghi et al.

Summary: Selenium is a crucial trace element for regulating immune functions and plays important roles in cancer. At nutritional low doses, selenium acts as an antioxidant, while at supra-nutritional high doses, selenium induces redox signaling and cell death.

EUROPEAN JOURNAL OF CANCER (2021)

Review Immunology

The 'cytokine storm': molecular mechanisms and therapeutic prospects

Rajendra Karki et al.

Summary: CSS is a collection of clinical manifestations caused by an overactivated immune system, associated with infectious diseases, immunodeficiencies, and therapeutic interventions. Despite the tissue damage and multiorgan failure caused by CS, there is still a lack of systematic understanding of its underlying molecular mechanisms.

TRENDS IN IMMUNOLOGY (2021)

Review Pharmacology & Pharmacy

Bioactive modulators targeting STING adaptor in cGAS-STING pathway

Xi Feng et al.

DRUG DISCOVERY TODAY (2020)

Article Chemistry, Medicinal

Development and Therapeutic Potential of Selenazo Compounds

Ana Carolina Ruberte et al.

JOURNAL OF MEDICINAL CHEMISTRY (2020)

Article Chemistry, Medicinal

Targeting Stimulator of Interferon Genes (STING): A Medicinal Chemistry Perspective

Han Zhang et al.

JOURNAL OF MEDICINAL CHEMISTRY (2020)

Article Chemistry, Multidisciplinary

Optical Control of Small Molecule-Induced Protein Degradation

Yuta Naro et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Review Medicine, General & Internal

Challenges and Opportunities in the Clinical Development of STING Agonists for Cancer Immunotherapy

Leila Motedayen Aval et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Review Chemistry, Multidisciplinary

Visible-to-NIR-Light Activated Release: From Small Molecules to Nanomaterials

Roy Weinstain et al.

CHEMICAL REVIEWS (2020)

Article Multidisciplinary Sciences

Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic

Emily N. Chin et al.

SCIENCE (2020)

Article Chemistry, Multidisciplinary

A Photo-responsive Small-Molecule Approach for the Opto-epigenetic Modulation of DNA Methylation

Ha Phuong Nguyen et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Article Multidisciplinary Sciences

Structural basis of STING binding with and phosphorylation by TBK1

Conggang Zhang et al.

NATURE (2019)

Article Multidisciplinary Sciences

Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP

Guijun Shang et al.

NATURE (2019)

Review Genetics & Heredity

DNA sensing by the cGAS-STING pathway in health and disease

Mona Motwani et al.

NATURE REVIEWS GENETICS (2019)

Review Cell Biology

Innate immunity signalling and membrane trafficking

Tomohiko Taguchi et al.

CURRENT OPINION IN CELL BIOLOGY (2019)

Article Chemistry, Multidisciplinary

Photoactivation of MDM2 Inhibitors: Controlling Protein-Protein Interaction with Light

Mickel J. Hansen et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

Article Multidisciplinary Sciences

Design of amidobenzimidazole STING receptor agonists with systemic activity

Joshi M. Ramanjulu et al.

NATURE (2018)

Review Biochemistry & Molecular Biology

Why Nature Chose Selenium

Hans J. Reich et al.

ACS CHEMICAL BIOLOGY (2016)

Review Immunology

STING: infection, inflammation and cancer

Glen N. Barber

NATURE REVIEWS IMMUNOLOGY (2015)

Review Chemistry, Multidisciplinary

Photoremovable Protecting Groups in Chemistry and Biology: Reaction Mechanisms and Efficacy

Petr Klan et al.

CHEMICAL REVIEWS (2013)

Review Oncology

Zebrafish cancer: the state of the art and the path forward

Richard White et al.

NATURE REVIEWS CANCER (2013)

Review Oncology

Zebrafish as a cancer model

Harma Feitsma et al.

MOLECULAR CANCER RESEARCH (2008)