A review of metal nanoparticle-based surface-enhanced Raman scattering substrates for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection Special Collection: Distinguished Australian Researchers

Monitoring an infectious disease early using highly sensitive and non-invasive techniques is critical for human health. Interestingly, the development of surface-enhanced Raman scattering (SERS) for biological detection ideally fits these medical requirements and is rapidly growing as a powerful diagnostic tool. SERS can enhance the Raman signal of the target molecule by more than 10(6) after the adsorption of the molecule on the plasmonic nanostructured surface. This review provides an overview of the use of gold and silver nanoparticles in SERS substrate designs, followed by the development of these SERS substrates in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection.

Automated summary

Early monitoring of infectious diseases is crucial for human health, and surface-enhanced Raman scattering (SERS) is rapidly growing as a powerful diagnostic tool that meets these requirements. SERS can significantly amplify the Raman signal of target molecules by more than 10^6 through the adsorption of molecules on plasmonic nanostructured surfaces. This review provides an overview of the use of gold and silver nanoparticles in SERS substrate designs and their development in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection.