Concurrent tandem catalysis enabled by nanomechanical motion in heteroleptic four-component dual-catalyst machinery

When the basic ligand 3 was added to the heteroleptic three-component slider-on-deck [Ag-3(1)(2)](3+) (sliding frequency k(298) = 57 kHz), it operated as a moderate brake pad (k(298) = 45 kHz). Due to motion in the resulting four-component slider-on-deck [Ag-3(1)(2)(3)](3+), both ligand 3 and silver(i) were continuously exposed and became catalytically active in a concurrent tandem Michael addition/hydroalkoxylation.

Automated summary

When the basic ligand 3 was added to the heteroleptic three-component slider-on-deck [Ag-3(1)(2)](3+), it acted as a moderate brake pad (k(298) = 45 kHz). The resulting motion in the four-component slider-on-deck [Ag-3(1)(2)(3)](3+) allowed both ligand 3 and silver(i) to be continuously exposed and become catalytically active in a tandem Michael addition/hydroalkoxylation.