期刊
G3-GENES GENOMES GENETICS
卷 7, 期 2, 页码 467-479出版社
GENETICS SOCIETY AMERICA
DOI: 10.1534/g3.116.037333
关键词
ecdysteroidogenesis; immune response; cytochrome p450; Halloween genes; molting
资金
- Australian Research Council [DP130102415]
- Australian Postgraduate Award
- Dame Margaret Blackwood Soroptimist Scholarship
- John A. McKenzie/Selby Scientific Foundation Award
In Drosophila melanogaster larvae, the ring gland (RG) is a control center that orchestrates major developmental transitions. It is a composite organ, consisting of the prothoracic gland, the corpus allatum, and the corpora cardiaca, each of which synthesizes and secretes a different hormone. Until now, the RG's broader developmental roles beyond endocrine secretion have not been explored. RNA sequencing and analysis of a new transcriptome resource from D. melanogaster wandering third instar larval RGs has provided a fascinating insight into the diversity of developmental signaling in this organ. We have found strong enrichment of expression of two gene pathways not previously associated with the RG: immune response and fatty acid metabolism. We have also uncovered strong expression for many uncharacterized genes. Additionally, RNA interference against RG-enriched cytochrome p450s Cyp6u1 and Cyp6g2 produced a lethal ecdysone deficiency and a juvenile hormone deficiency, respectively, flagging a critical role for these genes in hormone synthesis. This transcriptome provides a valuable new resource for investigation of roles played by the RG in governing insect development.
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