期刊
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
卷 41, 期 1, 页码 1-5出版社
CLINICAL & EXPER RHEUMATOLOGY
关键词
artificial neural networks; gender influence; evolutionary algorithms; rheumatic diseases; psoriatic arthritis
类别
Despite medical research being predominantly male-focused, efforts have been made to overcome this gender bias. Retrospective examination of 21 datasets found that gender information was included in the predictive model 19 out of 21 times, highlighting its importance even in highly adaptive tools like Artificial Neural Networks. The study also showed that gender information significantly improved the accuracy of predicting psoriatic arthritis diagnoses using ANNs.
Although medical research has been performed predominantly on men both in preclinical and clinical studies, continuous efforts have been made to over-come this gender bias.Examining retrospectively 21 data sets containing sex as one of the descriptive variables, it was possible to verify how many times our AI protocol decided to keep gender information in the predictive model. The data sets pertained a vast array of diseases such as dyspeptic syndrome, atrophic gastritis, venous thrombosis, gastroesophageal reflux disease, irritable bowel syndrome, Alzheimer diseases and mild cognitive impairment, myocardial infarction, gastrointestinal bleeding, gastric cancer, hypercortisolism, AIDS, COVID diagnosis, extracorporeal membrane oxy-genation in intensive therapy, among others. The sample size of these data sets ranged between 80 and 3147 (average 600). The number of variables ranged from 19 to 101 (average 41). Gender resulted to be part of the heuristic predictive model 19 out of 21 times. This means that also for highly adaptive and potent tools like Artificial Neural Networks, information on sex carries a specific value.In the field of rheumatology, there is a specific example in psoriatic arthritis that shows that the presence of gender information allows a significantly better accuracy of ANNs in predicting diagnosis from clinical data (from 87.7% to 94.47%).The results of this study confirm the importance of gender information in building high performance predictive model in the field of Artificial Intelligence (AI). Therefore, also for AI, sex counts.
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