Ovarian Response can be Predicted in Women with PCOS who have Ovulation Induction with Letrozole

Objective: To compare the clinical, metabolic, and hormonal characteristics of patients with and without selected dominant follicles in infertile women with PCOS who used letrozole for ovulation induction. Methodology: Eighty-eight female patients with PCOS, who underwent ovulation induction by giving 5 mg/day letrozole, were screened for demographic characteristics, laboratory values, and dominant follicle development. Those who were given letrozole as the first treatment agent, those who took clomiphene citrate (CC) and started letrozole the following month, and those who were treated with letrozole and given letrozole again were recorded separately. Seventy-five patients responded to letrozole and developed a dominant follicle; 13 patients did not develop a dominant follicle. Threshold values were determined for statistically significant parameters between patients with and without dominant follicles. Results: Follicle development occurred in 85.2% of the women. A statistically significant variable in clinical and metabolic values, between ovulating and non-ovulating groups could not be found. There was a significant difference between the two groups for the serum AMH value, total testosterone value, and FSH level. The authors found that follicle response was higher in those with AMH values less than 11.89 ng/mL, FSH levels higher than 6.25 Iu/L, and total testosterone less than 0.96 ng/mL. In this study, the pregnancy rate was found to be lower than in the literature (11%). Conclusion: Among the women with PCOS who had ovulation induction with letrozole, follicle development was higher in women with lower FSH, androgen and AMH values.

Automated summary

This study compared the clinical, metabolic, and hormonal characteristics of infertile women with PCOS who had or did not have follicle development after using letrozole for ovulation induction. Results showed that follicle development occurred in 85.2% of the women. There were no significant differences in clinical and metabolic values between ovulating and non-ovulating groups, but significant differences were observed in serum AMH value, total testosterone value, and FSH level. The study found that women with lower FSH, androgen, and AMH values had a higher rate of follicle development.