期刊
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
卷 23, 期 5, 页码 1134-1139出版社
VERDUCI PUBLISHER
关键词
Multiple myeloma; Cancer pain; Breakthrough pain; Opioids; Palliative care
The aim of this study was to characterize breakthrough pain (BTcP) in patients with multiple myeloma (MM). The results showed that BTcP in patients with MM was more predictable compared to other tumors, with the main trigger being physical activity. There were no differences in other BTcP characteristics, pattern of opioids used for background pain, and patient satisfaction and adverse effects.
OBJECTIVE: The aim of this study was to characterize breakthrough pain (BTcP) in patients with multiple myeloma (MM). PATIENTS AND METHODS: This was a sec-ondary analysis of a large multicenter study of patients with BTcP. Background pain intensity and opioid doses were recorded. The BTcP char-acteristics, including the number of BTcP ep-isodes, intensity, onset, duration, predictabil-ity, and interference with daily activities were recorded. Opioids prescribed for BTcP, time to achieve a meaningful pain relief after taking a medication, adverse effects, and patients' satis- faction were assessed.RESULTS: Fifty-four patients with MM were ex-amined. In comparison with other tumors, in pa-tients with MM BTcP was more predictable (p=0.04), with the predominant trigger being the physical ac-tivity (p<0.001). Other BTcP characteristics, pattern of opioids used for background pain and BTcP, sat-isfaction and adverse effects did not differ.CONCLUSIONS: Patients with MM have their own peculiarities. Given the peculiar involve-ment of the skeleton, BTcP was highly predict-able and triggered by movement.
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