☆ 4.5 Review

Exclusion of older adults and immunocompromised individuals in influenza, pneumococcal and COVID-19 vaccine trials before and after the COVID-19 pandemic

AGING CLINICAL AND EXPERIMENTAL RESEARCH (2023)

Age and Ageing journal 50th anniversary commentary series Clinical trials in older people

Kaisu H. Pitkala et al.

Summary: Randomised controlled trials provide the best evidence for treatments and management, but older people have traditionally been excluded due to various factors. Recruitment and retention of older participants are challenging, and other issues can lead to biased intervention effects. However, RCTs in geriatrics should still be promoted as reliable evidence is needed for the successful treatment and management of older people.

AGE AND AGEING (2022)

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Review Cell Biology

Underrepresentation of older adults in clinical trials on COVID-19 vaccines: A systematic review

Nicola Veronese et al.

Summary: The study found that only a small fraction of older people, who were disproportionately affected by COVID-19, were included in clinical trials evaluating the efficacy of COVID-19 vaccines.

AGEING RESEARCH REVIEWS (2021)

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Article Public, Environmental & Occupational Health

Global, regional, and national estimates of the population at increased risk of severe COVID-19 due to underlying health conditions in 2020: a modelling study

Andrew Clark et al.

LANCET GLOBAL HEALTH (2020)

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Letter Medicine, General & Internal

The Exclusion of Older Persons From Vaccine and Treatment Trials for Coronavirus Disease 2019-Missing the Target

Benjamin K. I. Helfand et al.

JAMA INTERNAL MEDICINE (2020)

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Editorial Material Medicine, General & Internal

Inclusion Across the Lifespan NIH Policy for Clinical Research

Marie A. Bernard et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2018)

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Exclusion of older adults and immunocompromised individuals in influenza, pneumococcal and COVID-19 vaccine trials before and after the COVID-19 pandemic

相关参考文献

Age and Ageing journal 50th anniversary commentary series Clinical trials in older people

Underrepresentation of older adults in clinical trials on COVID-19 vaccines: A systematic review

Global, regional, and national estimates of the population at increased risk of severe COVID-19 due to underlying health conditions in 2020: a modelling study

The Exclusion of Older Persons From Vaccine and Treatment Trials for Coronavirus Disease 2019-Missing the Target

Inclusion Across the Lifespan NIH Policy for Clinical Research

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