Recrystallization of 2D C-MOF Films for High-Performance Electrochemical Sensors

Human milk (HM) lipid plays a crucial role in infant development, whereas its complex lipid profiles and its dynamic changes during prolonged lactation have not been investigated yet. Comparative lipidomic analyses were employed in investigating the lipid profiles of breast milk covering all lactation stages herein. Results revealed significant differences between colostrum and the remaining lactations. A total of 237 species of glycerolipids (GLs) and 231 phospholipids (PLs) were identified. Colostrum had the most abundant lipid species and was enriched with triacylglycerols (TGs) with a high molecular weight. TG(17:1/18:1/24:1), TG(24:1/24:1/26:1), TG(24:0/24:1/26:1), and SM(d20:1/14:1) were characteristic lipids of colostrum. Differential lipid species which were responsible for distinguishing the adjacent lactations were also indicated. Our findings can help deepen the overall understanding of HM lipid profiles and its dynamic changes, which will facilitate the development of infant formulas suitable for Chinese babies in diverse age groups.

Automated summary

In this study, comparative lipidomic analyses were used to investigate the lipid profiles of breast milk at different lactation stages. Results showed significant differences between colostrum and the remaining lactations, with colostrum having the most abundant lipid species. Specific lipid species responsible for distinguishing adjacent lactations were also identified. These findings contribute to a deeper understanding of human milk lipid composition and its dynamic changes, and can inform the development of infant formulas suitable for Chinese babies in diverse age groups.